Cytotoxic effect of conjugates of doxorubicin and human chorionic gonadotropin (hCG) in breast cancer cells

Breast Cancer Research and Treatment

Volumn 77, Issue 2, 2003, Pages 125-131

  Gebauer, Gerhard ^a,b   Fehm, Tanja ^c,d   Beck, Eberhard P ^e   Berkholz, Alexander ^f   Licht, Peter ^c   Jäger, Wolfram ^f  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b SIDNEY KIMMEL CANCER CENTER   (United States)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e Olgaspital ^*  (Germany)

^f UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Breast cancer; Doxorubicin; Drug conjugates; hCG

Indexed keywords

ALBUMIN; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN RECEPTOR; DOXORUBICIN; MESSENGER RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPATHOGENIC EFFECT; CYTOSTASIS; DRUG CONJUGATION; DRUG EFFECT; DRUG SELECTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA SEQUENCE;

ALBUMINS; ANTIBIOTICS, ANTINEOPLASTIC; BREAST NEOPLASMS; CHORIONIC GONADOTROPIN; DOXORUBICIN; DRUG CARRIERS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; RECEPTORS, LH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0037272775     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021301001208     Document Type: Article

References (28)

1. Chabner B: Cancer Chemotherapy, Principles and Practice. J.B. Lippincott, Philadelphia, 1990
2. Magrath T: Targeted appoaches to cancer therapy. Int J Cancer 56: 163-166, 1994
3. Ehrlich P: The relationship existing between chemical constitution, distribution and pharmacological action. In: Himmelweite, Marquard M, Dale H, Elmsford (eds) The Collected Papers of Paul Ehrlich. Vol 1, Pergamon, New York, 1956, pp 596-618
4. Pastan I, Fitzgerald D: Recombinant toxins for cancer treatment. Science 254: 1173-1177, 1991
5. Yeh MW, Roffler SR, Yu MH: Doxorubicin: monoclonal antibody conjugate for therapy of human cervical cancer. Int J Cancer 51: 274-282, 1992
6. Fritzer M, Barabas K, Szüts V, Berczi A, Szekeres T, Faulk WP, Goldenberg H: Cytotoxicity of a transferrin-adriamycin conjugate to anthracycline-resistant cells. Int J Cancer 52: 619-623, 1992
7. Gabor F, Wollmann K, Theyer G, Haberl I, Hamilton G: In vitro antiproliferative effects of albumin-doxorubizin conjugates against Ewing's sarcoma and peripheral neuroectodermal tumor cells. Anticancer Res 14: 1943-1950, 1994
8. Zhang W, Lei ZM, Rao CV: Immortalized hippocampal cells contain functional luteinizing hormone/human chorionic gonadotropin receptors. Life Sci 65: 2083-2098, 1999
9. Tao YX, Heit M, Lei ZM, Rao CV: The urinary bladder of a woman is a novel site of luteinizing hormone-human chorionic gonadotropin receptor gene expression. Am J Obstet Gynecol 179: 1026-1031, 1998
10. Hu YL, Lei ZM, Huang ZH, Rao CV: Determinants of transcription of the chorionic gonadotropin/luteinizing hormone receptor gene in human breast cells. Breast J 5: 186-193, 1999
11. Licht P, Wildt L: Gonadal and extragonadal receptors for human chorionic gonadotropin (hCG) and luteinizing hormone (LH). Ass Reprod Rev 8: 152-172, 1998
12. Emons G, Schally AW: The use of luteinizing hormone releasing hormone agonists and antagonists in gynecological cancer. Hum Reprod 9: 1364-1369, 1994
13. Schally AV, Comaru-Schally AM: Rational use of agonists and antagonists of luteinizing hormone releasing hormone (LH-RH) in the treatment of hormone sensitive neoplasms and gynecologic conditions. Adv Drug Delivery Rev 28: 157-169, 1997
14. Page M, Thibeault D, Noel C, Dumas L: Coupling a preactivated daunorubicin derivate to antibody. A new approach. Anticancer Res 10: 353-358, 1990
15. Licht P, Wildt L: Multiplex nested rT-PCR for sensitive and specific detection of full-length hCG/LH receptor messenger RNA. Hum Reprod 11: 12, 1996
16. Bernhardt G, Reile H, Birnböck H, Spruß T, Schönenberger H: Standardized kinetic microassay to quantify differential chemosensitivity on the basis of proliferative activity. J Cancer Res Clin Oncol 118: 35-43, 1992
17. Magrath T: Targeted approaches to cancer therapy. Int J Cancer 56: 163-166, 1994
18. Affleck K, Embleton MJ: Monoclonal antibody targeting of methotrexate (MTX) against MTX-resistent tumour cell lines. Br J Cancer 65: 838-844, 1992
19. Belles-Isles M, Page M: In vitro activity of daunomycin-anti-alphafoetoprotein conjugate on mouse hepatoma cells. Br J Cancer 41: 841-842, 1980
20. Gruber R, van Haarlem LJM, Warnaar SO, Holz E, Riethmueller G: The human antimouse immunoglobulin response and the anti-idiotypic network have no influence on clinical outcome in patients with minimal residual colorectal cancer treated with monoclonal antibody CO17-1A. Cancer Res 60: 1921-1926, 2000
21. Mitra S, Gaur U, Ghosh PC, Maitra AN: Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. J Cont Release 74: 317-323, 2001
22. Dagar S, Sekosan M, Lee BS, Rubinstein I, Onyuksel H: VIP receptors as molecular targets of breast cancer: implications for targeted imaging and drug delivery. J Cont Release 74: 129-134, 2001
23. Konyves I, Muntzing J, Rocencweig: Chemotherapy principles in the treatment of prostatic cancer. Prostate 5: 55-62, 1984
24. Lojun S, Bao S, Lei ZM, Rao CV: Presence of functional luteinizing hormone/chorionic gonadotropin (hCG) receptors in human breast cell lines: implications supporting the premise that hCG protects women against breast cancer. Biol Reprod 57: 1202-1210, 1997
25. Srivastava P, Russo J, Russo IH: Chorionic gonadotropin inhibits rat mammary carcinogenesis through activation of programmed cell death. Carcinogenesis 18: 1799-1808, 1997
26. Russo IJ, Russo J: Hormonal approach to breast cancer prevention. J Cell Biochemistry, 34(suppl): 1-6, 2000
27. Srivastava P, Russo J, Russo IH: Inhibition of rat mammary tumorigenesis by human chorionic gonadotropin associated with increased expression of inhibin. Mol Carcinogen 26: 10-19, 1999
28. Jiang X, Russo IH, Russo J: Human chorionic gonadotropin and inhibin induce histone acetylation in human breast epithelial cells. Int J Oncol 20: 77-79, 2002