The first supported N-pyridinyl proline-derived chiral catalyst for the kinetic resolution of racemic alcohols

Synlett

Volumn , Issue 5, 2003, Pages 679-683

  Pelotier, Béatrice ^a   Priem, Ghislaine ^a   Campbell, Ian B ^a   Macdonald, Simon J F ^a   Anson, Mike S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Alcohols; Asymmetric catalysis; Enantioselective acylations; Kinetic resolution; Supported catalysts

Indexed keywords

ALCOHOL DERIVATIVE; PROLINE; PYRIDINE DERIVATIVE;

ACYLATION; ARTICLE; ASYMMETRIC CATALYSIS; CATALYST; CHEMICAL REACTION KINETICS; CHIRALITY; ENANTIOSELECTIVITY; RECYCLING; SYNTHESIS;

EID: 0037270111     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-38354     Document Type: Article

References (23)

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20. 2 (5x) and dried in a vacuum oven at 50°C. A negative TNBS test indicated all amine sites had reacted.
21. 2 (5 x) and dried in a vacuum oven at 50°C.
22. 2 (5x) and dried in a vacuum oven at 50°C.
23. 3 (10 mL/mmol) was added, followed by isobutyric anhydride (1.2 equiv). The resulting mixture was shaken at r.t.