Is the arginine-nitric oxide pathway involved in the pathogenesis of schizophrenia?

Neuropsychobiology

Volumn 47, Issue 2, 2003, Pages 61-65

  Yanik, Medaim ^a   Vural, Huseyin ^a   Kocyiǧit, Abdurrahim ^a   Tutkun, Hamdi ^b   Zoroǧlu, Süleyman Salih ^b   Herken, Hasan ^b   Savaş, Haluk Asuman ^b   Köylü, Alpay ^a   Akyol, Ömer ^c  

^a HARRAN UNIVERSITY   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

^c INONU UNIVERSITY   (Turkey)

Author keywords

Arginase; Manganese; Nitric oxide; Schizophrenia

Indexed keywords

ARGINASE; MANGANESE; NITRIC OXIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; MALE; MENTAL DISEASE; PATHOGENESIS; PRIORITY JOURNAL; SCHIZOPHRENIA; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADULT; ARGINASE; ARGININE; BLOOD CHEMICAL ANALYSIS; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MANGANESE; MIDDLE AGED; NITRIC OXIDE; SCHIZOPHRENIA;

EID: 0037266247     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070010     Document Type: Article

References (28)

1. Jenkinson CP, Grody WW, Cederbaum SD: Comparative properties of arginases. Comp Biochem Physiol B Biochem Mol Biol 1996;114:107-132.
2. Brock AA, Chapman SA, Ulman EA, Wu G: Dietery manganese deficency decreases rat hepatic arginase activity. J Nutr 1994;124:340-344.
3. Diez AM, Campo ML, Soler G: Trypsin digestion of arginase: Evidence for a stable confirmation manganese directed. Int J Biochem 1992;24:1925-1932.
4. Elgun S, Kumbasar H: Increased serum arginase activity in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2000;24:227-232.
5. Dawson VL, Dawson TM: Nitric oxide actions in neurochemistry. Neurochem Int 1996;29: 97-110.
6. Das I, Khan NS, Puri BK, Sooranna SR, de Belleroche J, Hirsch SR: Elevated platelet calcium mobilization and nitric oxide synthase activity may reflect abnormalities in schizophrenic brain. Biochem Biophys Res Commun 1995;212:375-380.
7. Akbarian S, Bunney WE Jr, Potkin SG, Wigal SB, Hagman JO, Sandman CA, Jones EG: Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch Gen Psychiatry 1993;50:169-177.
8. Akbarian S, Vinuela A, Kim JJ, Potkin SG, Bunny WE Jr, Jones EG: Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development. Arch Gen Psychiatry 1993;50:178-187.
9. Deutsch SI, Rosse RB, Schwartz BL, Fay-McCarthy M, Rosenberg PB, Fearing K: Methylene blue adjuvant therapy of schizophrenia. Clin Neuropharmacol 1997;20:357-363.
10. Albina JE, Mills CD, Henry WL, Caldwell MD: Temporal expression of different pathways of L-arginine metabolism in healing wounds. J Immunol 1990;144:3877-3880.
11. Durak I, Ozturk HS, Elgun S, Cimen MYB, Yalcin S: Erythrocyte nitric oxide metabolism in patients with chronic renal failure. Clin Nephrol 2001;55:460-464.
12. Huang LW, Chang KL, Chen CJ, Liu HW: Arginase levels are increased in patients with rheumatoid arthritis. Kaohsiung J Med Sci 2001;17:358-363.
13. Jansen A, Lewis S, Cattell V, Cook HT: Arginase is a major pathway of L-arginine metabolism in nephritic glomeruli. Kidney Int 1992;42:1107-1112.
14. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington, American Psychiatric Association, 1994.
15. Moncada S, Palmer RM, Higgs EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-142.
16. Koltuksuz U, Irmak MK, Karaman A, Uz E, Var A, Ozyurt H, Akyol O: Testicular nitric oxide levels after unilateral testicular torsion/detorsion in rats pretreated with caffeic acid phenethyl ester. Urol Res 2000;28:360-363.
17. Cortas NK, Wakid NW: Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 1990;36:1440-1443.
18. Somogyi M: A method for the preparation of blood filtrates for the determination of sugar. J Biol Chem 1930;86:655-663.
19. Geyer JW, Dabich D: Rapid method for determination of arginase activity in tissue homogenates. Anal Biochem 1971;39:412-417.
20. Silverman LM, Christenson RH: Amino acid and proteins; in Burtis CA, Ashwood ER (eds): Textbook of Clinical Chemistry. Philadelphia, WB Saunders, 1994, pp 695-697.
21. Brodie KG, Routh MW: Trace analysis of lead in blood, aluminium and manganese in serum and chromium in urine by graphite furnace atomic absorption spectrometry. Clin Biochem 1984;17:19-26.
22. Karson CN, Griffin WS, Mrak RE, Husain M, Dawson TM, Snyder SH, Moore NC, Sturner WQ: Nitric oxide synthase (NOS) in schizophrenia: Increases in cerebellar vermis. Mol Chem Neuropathol 1996;27:275-284.
23. Herken H, Uz E, Ozyurt H, Akyol O: Red blood cell nitric oxide levels in patients with schizophrenia. Schizophr Res 2001;52:289-290.
24. Sadasivudu B, Rao TI: Studies on functional and metabolic role of urea cycle intermediates in brain. J Neurochem 1976;27:785-794.
25. Cotter D, Landau S, Beasley C, Stevenson R, Chana G, Macmillan L, Everall I: The density and spatial distribution of GABAergic neurons, labelled using calcium-binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder and schizophrenia. Biol Psychiatry 2002;51:377-386.
26. Mizukami K, Ishikawa M, Hidaka S, Iwakiri M, Sasaki M, Iritani S: Immunohistochemical localization of GABAB receptor in the entorhinal cortex and inferior temporal cortex of schizophrenic brain. Prog Neuropsychopharmacol Biol Psychiatry 2002;26:393-396.
27. Giovannoni G, Heales SJ, Silver NC, O'Riodan J, Miller RF, Land JM, Clark JB, Thompson EJ: Raised serum nitrate and nitrite levels in patients with multiple sclerosis. J Neurol Sci 1997;145:77-81.
28. Hampel H, Kotter HU, Moller HJ: Blood-cerebrospinal fluid barrier dysfunction for high molecular weight protein in Alzheimer disease and major depression: Indication for disease subsets. Alzheimer Dis Assoc Disord 1997;11:78-87.