Survival of allografted pancreatic islets in the subretinal space in rats

Ophthalmic Research

Volumn 35, Issue 1, 2003, Pages 48-53

  Inoue, Makoto ^a,c   Maeno, Takatoshi ^a   Hatchell, Diane L ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Immune privilege; Islet of Langerhans; Islet transplantation; Subretinal transplant

Indexed keywords

COLLAGENASE; GLUCAGON; INSULIN; PARAFFIN; PEROXIDASE;

ALLOGRAFT; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; ENDOCRINE CELL; ENUCLEATION; GRAFT SURVIVAL; IMMUNE SYSTEM; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT; RETINA; STAINING; T LYMPHOCYTE; VITREOUS BODY;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CELL SURVIVAL; CONJUNCTIVA; EXTRACELLULAR SPACE; GLUCAGON; GRAFT SURVIVAL; IMMUNITY; IMMUNOENZYME TECHNIQUES; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; RATS; RATS, SPRAGUE-DAWLEY; RETINA; TRANSPLANTATION, HOMOLOGOUS;

EID: 0037259183     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068197     Document Type: Article

References (17)

1. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus: The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329:977-986.
2. Keen H: The Diabetes Control and Complications Trial (DCCT): Health Trends 1994;26:41-43.
3. Barker CF, Markmann JF, Posselt AM, Naji A: Studies of privileged sites and islet transplantation. Transplant Proc 1991;23:2138-142.
4. Perico N, Barbui C, Remuzzi G: Studies of privileged sites and organ transplantation. Exp Nephrol 1993;1:120-127.
5. Ferguson J, Scothorne RJ: Extended survival of pancreatic islet allografts in the testis of guinea-pigs: J Anat 1977;124:1-8.
6. Jiang LQ, Jorquera M, Streilein JW: Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts: Invest Ophthalmol Vis Sci 1993;34:3347-3354.
7. Jiang LQ, Jorquera M, Streilein JW: Immunologic consequences of intraocular implantation of retinal pigment epithelial allografts. Exp Eye Res 1994;58:719-728.
8. Ksander BR, Streilein JW: Failure of infiltrating precursor cytotoxic T cells to acquire direct cytotoxic function in immunologically privileged sites. J Immunol 1990;145:2057-2063.
9. Wenkel H, Streilein JW: Analysis of immune deviation elicited by antigens injected into the subretinal space. Invest Ophthalmol Vis Sci 1998;39:1823-1834.
10. Hatchell DL, Embabi SN, Maeno T, Saloupis P, Olson G, Braun RD, Toth CA: Transplantation of feline islets of Langerhans in the subretinal space of cat eyes. Transplant Proc 1998;30:593-595.
11. Streilein JW: Anterior chamber associated immune deviation: the privilege of immunity in the eye. Surv Ophthalmol 1990;35:67-73.
12. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA: Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995;270:1189-1192.
13. Griffith TS, Yu X, Herndon JM, Green DR, Ferguson TA: CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 1996;5:7-16.
14. Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC: A role for CD95 ligand in preventing graft rejection. Nature 1995;377:630-632.
15. Linsenmeier RA, Braun RD, McRipley MA, Padnick LB, Ahmed J, Hatchell DL, Mcleod DS, Lutty GA: Retinal hypoxia in long-term diabetic cats. Invest Ophthalmol Vis Sci 1998;39:1647-1657.
16. Haimann MH, Abrams GW, Edelhauser HF, Hatchell DL: The effect of intraocular irrigating solutions on lens clarity in normal and diabetic rabbits. Am J Ophthalmol 1982;94:594-605.
17. Kohen L, Enzmann V, Faude F, Wiedemann P: Mechanisms of graft rejection in the transplantation of retinal pigment epithelial cells. Ophthalmic Res 1997;29:298-304.