Effects of non-steroidal anti-inflammatory drugs on the methotrexate transport in rat small intestine

Scandinavian Journal of Gastroenterology

Volumn 38, Issue 1, 2003, Pages 43-49

  Sosogi, A ^a   Gao, F ^a   Tomimatsu, T ^a   Hirata, K ^a   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

ATP; Methotrexate; Non steroidal anti inflammatory drug; Small intestine; Transport

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); DICLOFENAC; FLUFENAMIC ACID; FOLIC ACID; INDOMETACIN; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT;

ACTIVE TRANSPORT; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRUSH BORDER; BRUSH BORDER VESICLE; CONTROLLED STUDY; DRUG CROSS REACTIVITY; DRUG TRANSPORT; HYDROPHOBICITY; INTESTINE ABSORPTION; INTESTINE MUCOSA; MALE; MEMBRANE FLUIDITY; MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PASSIVE TRANSPORT; PRIORITY JOURNAL; RAT; RHEUMATIC DISEASE; SMALL INTESTINE ABSORPTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL TRANSPORT, ACTIVE; DICLOFENAC; FLUFENAMIC ACID; FOLIC ACID ANTAGONISTS; INDOMETHACIN; INTESTINE, SMALL; MALE; METHOTREXATE; NA(+)-K(+)-EXCHANGING ATPASE; RATS; RATS, WISTAR;

EID: 0037255205     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520310000429     Document Type: Article

References (41)

1. Bannwarth B, Pehourcq F, Schaeverbeke T, Schaeverbeke T, Dehais J. Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis. Clin Pharmacokinet 1996;30:194-210.
2. Camiciottoli G, Trapani S, Castellani W, Ginanni R, Ermini M. Effect on lung function of methotrexate and non-steroid anti-inflammatory drugs in children with juvenile rheumatoid arthritis. Rheumatol Int 1998;18:11-6.
3. Cron RQ, Sharma S, Sherry DD. Current treatment by United States and Canadian pediatric rheumatologists. J Rheumatol 1999;26:2036-8.
4. Brooks PM, Day RO. Nonsteroidal antiinflammatory drugs: differences and similarities. N Engl J Med 1991;324:1716-25.
5. Strum WB. A pH-dependent, carrier-mediated transport system for the folate analog, amethopterin, in rat jejunum. J Pharmacol Exp Ther 1977;203:640-5.
6. Strum WB. Characteristics of the transport of pteroylglutamate and amethopterin in rat jejunum. J Pharmacol Exp Ther 1981; 216:329-33.
7. Schron CM, Washington C, Blitzer BL. The transmembrane pH gradient drives uphill folate transport in rabbit jejunum. Direct evidence for folate/hydroxyl exchange in brush border membrane vesicles. J Clin Invest 1985;76:2030-3.
8. Dixon KH, Lanpher BC, Chiu J, Kelley K, Cowan KH. A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J Biol Chem 1994;269:17-20.
9. Williams FM, Murray RC, Underhill TM, Flintoff WF. Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake. J Biol Chem 1994;269:5810-6.
10. Moscow JA, Gong M, He R, Sgagias MK, Dixon KH, Anzick SL, et al. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res 1995;55:3790-4.
11. Wong SC, Proefke SA, Bhushan A, Matherly LH. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem 1995; 270:17468-75.
12. Said HM, Nguyen TT, Dyer DL, Cowan KH, Rubin SA. Intestinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA. Biochim Biophys Acta 1996;1281:164-72.
13. Said HM, Strum WB. A pH-dependent, carrier-mediated system for transport of 5-methyltetrahydrofolate in rat jejunum. J Pharmacol Exp Ther 1983;226:95-9.
14. McDougall P, Markham A, Cameron I, Sweetman AJ. The mechanism of inhibition of mitochondrial oxidative phosphorylation by the nonsteroidal anti-inflammatory agent diflunisal. Biochem Pharmacol 1983;32:2595-8.
15. Mahmud T, Rafi SS, Scott DL, Wrigglesworth JM, Bjarnason I. Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation. Arthritis Rheum 1996;39:1998-2003.
16. Masubuchi Y, Saito H, Horie T. Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes. J Pharmacol Exp Ther 1998;287:208-13.
17. Masubuchi Y, Yamada S, Horie T. Diphenylamine as an important structure of nonsteroidal anti-inflammatory drugs to uncouple mitochondrial oxidative phosphorylation. Biochem Pharmacol 1999;58:861-5.
18. Masubuchi Y, Yamada S, Horie T. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 2000;292:982-7.
19. Doluisio JT, Billups NF, Dittert LW, Sugita ET, Swintosky JV. Drug absorption. I. An in situ rat gut technique yielding realistic absorption rates. J Pharm Sci 1969;58:1196-2000.
20. Gao F, Horie T. Protective effect of prostaglandins on the methotrexate induced damage of small intestine in rats. In Vivo 2000;14:453-6.
21. Breithaupt H, Kuenzlen E, Goebel G. Rapid high-pressure liquid chromatographic determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N(10)-methylpteroic acid in biological fluids. Anal Biochem 1982;121:103-13.
22. Jourd'Heuil D, Vaananen P, Meddings JB. Lipid peroxidation of the brush-border membrane: membrane physical properties and glucose transport. Am J Physiol 1993;264:G1009-15.
23. Kessler M, Acuto O, Storelli C, Murer H, Muller M, Semenza GA. A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of D-glucose and choline transport systems. Biochim Biophys Acta 1978;506:136-54.
24. Malo C, Berteloot A. Analysis of kinetic data in transport studies: new insights from kinetic studies of Na(+)-D-glucose cotransport in human intestinal brush-border membrane vesicles using a fast sampling, rapid filtration apparatus. J Membr Biol 1991;122:127-41.
25. Tomimatsu T, Horie T. Increased Na(+)-dependent D-glucose transport in small intestine of retinyl palmitate treated rats. In Vivo 2001;15:81-6.
26. Fujita M, Matsui H, Nagano K, Nakao M. Asymmetric distribution of ouabain-sensitive ATPase activity in rat intestinal mucosa. Biochim Biophys Acta 1971;233:404-8.
27. Selhub J, Rosenberg IH. Folate transport in isolated brush border membrane vesicles from rat intestine. J Biol Chem 1981;256:4489-93.
28. Toskulkao C, Sutheerawattananon M, Piyachaturawat P. Inhibitory effect of steviol, a metabolite of stevioside, on glucose absorption in everted hamster intestine in vitro. Toxicol Lett 1995;80:153-9.
29. +ATPase: molar and specific activity, protein determination. Methods Enzymol 1988;156:105-15.
30. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagents. J Biol Chem 1951; 193:265-75.
31. Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K. Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett 1998;438:321-4.
32. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, et al. Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol 1999;55:847-54.
33. Masuda S, Saito H, Inui KI. Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1. J Pharmacol Exp Ther 1997;283:1039-42.
34. + gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine. J Pharmacol Exp Ther 1987;241:594-601.
35. Idoate I, Mendizabal MV, Urdaneta E, Larralde J. Interactions of cephradine and cefaclor with the intestinal absorption of D-galactose. J Pharm Pharmacol 1996;48:645-50.
36. Somasundaram S, Hayllar H, Rafi S, Wrigglesworth JM, Macpherson AJ, Bjarnason I. The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: a review and a hypothesis. Scand J Gastroenterol 1995;30:289-99.
37. Kajii H, Horie T, Hayashi M, Awazu S. Effects of salicylic acid on the permeability of the plasma membrane of the small intestine of the rat: a fluorescence spectroscopic approach to elucidate the mechanism of promoted drug absorption. J Pharm Sci 1986;75:475-8.
38. Kajii H, Horie T, Hayashi M, Awazu S. Effects of sodium salicylate and caprylate as an adjuvant of drug absorption on isolated rat small intestinal epithelial cells. Int J Pharm 1986;33:253-5.
39. Kajii H, Horie T, Hayashi M, Awazu S. Fluorescence study on the interaction of salicylate with rat small intestinal epithelial cells: possible mechanism for the promoting effects of salicylate on drug absorption in vivo. Life Sci 1985;37:523-30.
40. Giraud MN, Motta C, Romero JJ, Bommelaer G, Lichtenberger LM. Interaction of indomethacin and naproxen with gastric surface-active phospholipids: a possible mechanism for the gastric toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs). Biochem Pharmacol 1999;57:247-54.
41. Lugea A, Antolin M, Mourelle M, Guarner F, Malagelada JR. Deranged hydrophobic barrier of the rat gastroduodenal mucosa after parenteral nonsteroidal anti-inflammatory drugs. Gastroenterology 1997;112:1931-9.