Hepatocyte nuclear factor-4α/γ and hepatocyte nuclear factor-1α as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers

Pharmacogenetics

Volumn 13, Issue 1, 2003, Pages 49-53

  Ozeki, Takeshi ^a,e   Takahashi, Yoshiki ^a   Nakayama, Kazuo ^a   Funayama, Masato ^b   Nagashima, Kazuo ^c   Kodama, Takao ^d   Kamataki, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d Hokkaido Assoc Med Serv Workers   (Japan)

^e UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Genetic polymorphism; Quantitative RT PCR; Synergistic expression; Transcriptional regulation

Indexed keywords

DIHYDRODIOL DEHYDROGENASE; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HEPATOCYTE NUCLEAR FACTOR 4GAMMA; MESSENGER RNA; NUCLEAR FACTOR I; NUCLEAR FACTOR IALPHA; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CATALYSIS; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENOTYPE; HUMAN; HUMAN TISSUE; LIVER CELL; MALE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOBLASTOMA; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; LIVER; MODELS, GENETIC; NUCLEAR PROTEINS; OXIDOREDUCTASES; PHOSPHOPROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0037246433     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200301000-00007     Document Type: Article

References (17)

1. Glatt HR, Vogel K, Bentley P, Oesch F. Reduction of benzo[a]pyrene mutagenicity by dihydrodiol dehydrogenase. Nature 1979; 277: 319-320.
2. Burczynski ME, Harvey RG, Penning TM. Expression and characterization of four Recombinant human dihydrodiol dehydrogenase isoforms - oxidation of trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry 1998; 37:6781-6790.
3. Ohara H, Miyabe Y, Deyashiki Y, Matsuura K, Hara A. Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver. Biochem Pharmacol 1995; 50:221-227.
4. Hara A, Taniguchi H, Nakayama T, Sawada H. Purification and properties of multiple forms of dihydrodiol dehydrogenase from human liver. J Biochem (Tokyo) 1990; 108:250-254.
5. Penning TM, Sharp RB. Characterization of dihydrodiol dehydrogenase in human liver and lung. Carcinogenesis 1990; 11:1203-1208.
6. Ozeki T, Takahashi Y, Kume T, Nakayama K, Yokoi T, Nunoya K-I, et al. Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo-keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4α/γ and HNF-1α. Biochem J 2001; 355:537-544.
7. Khanna M, Qin KN, Wang RW, Cheng KC. Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3α-hydroxysteroid dehydrogenases. J Biol Chem 1995; 270:20162-20168.
8. Nakajima-Iijima S, Hamada H, Reddy P, Kakunaga T. Molecular structure of the human cytoplasmic β-actin gene: interspecies homology of sequences in the introns. Proc Natl Acad Sci USA 1985; 82: 6133-6137.
9. Higuchi R, Fockler C, Dollinger G, Watson R. Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Bio/Technology 1993; 11:1026-1030.
10. Kaisaki PJ, Menzel S, Lindner T, Oda N, Rjasanowski I, Sahm J, et al. Mutations in the hepatocyte nuclear factor-1α gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4. Diabetes 1997; 46:528-535.
11. Furuta H, Iwasaki N, Oda N, Hinokio Y, Horikawa Y, Yamagata K, et al. Organization and partial sequence of the hepatocyte nuclear factor-4α/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY. Diabetes 1997; 46:1652-1657.
12. Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, et al. Hepatocyte nuclear factor-4γ: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. Diabetes 1999; 48:2099-2102.
13. Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE, Jr., Crabtree GR. A transcriptional hierarchy involved in mammalian cell-type specification. Nature 1992; 355:457-461.
14. Zhong W, Mirkovitch J, Darnell JE, Jr. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Mol Cell Biol 1994; 14: 7276-7284.
15. Guengerich FP, Turvy CG. Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. J Pharmacol Exp Ther 1991; 256:1189-1194.
16. Chung I, Bresnick E. Regulation of the constitutive expression of the human CYP1A2 gene: cis elements and their interactions with proteins. Mol Pharmacol 1995; 47:677-685.
17. Umeno M, McBride OW, Yang CS, Gelboin HV, Gonzalez FJ. Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. Biochemistry 1988; 27:9006-9013.