The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients

Journal of Human Genetics

Volumn 48, Issue 3, 2003, Pages 138-141

  Nomiyama, Takashi ^a   Tanaka, Yasushi ^a   Piao, Lianshan ^b   Nagasaka, Keiko ^a   Sakai, Ken ^a   Ogihara, Takeshi ^a   Nakajima, Kunihiro ^a   Watada, Hirotaka ^a   Kawamori, Ryuzo ^a  

^a JUNTENDO UNIVERSITY   (Japan)

^b YANBIAN UNIVERSITY   (China)

Author keywords

Diabetic nephropathy; Mitochondria; Mn SOD; Polymorphism; ROS

Indexed keywords

ALANINE; MANGANESE SUPEROXIDE DISMUTASE; VALINE;

ADULT; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; EVALUATION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; JAPAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PROTEINURIA; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; AMINO ACID SEQUENCE; GENETIC ASSOCIATION; JAPANESE (PEOPLE); MACROALBUMINURIA; MIDDLE AGED; PATHOGENESIS; POLYMERASE CHAIN REACTION RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0037242288     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380300021     Document Type: Article

References (12)

1. Chistyakov DA, Savost'anov KV, Zotova EV, Nosikov VV (2001) Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 I diabetes mellitus. BMC Med Genet 2:4
2. Guidot DM, McCord JM, Wright RM, Repine JE (1993) Absence of electron transport (Rho 0 state) restores growth of a manganesesuperoxide dismutase-deficient Saccharomyces cerevisiae in hyperoxia. Evidence for electron transport as a major source of superoxide generation in vivo. J Biol Chem 268:26699-26703
3. Hiroi S, Harada H, Nishi H, Satoh M, Nagai R, Kimura A (1999) Polymorphisms in the SOD2 and HLA-DRBI genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. Biochem Biophys Res Commun 261:332-339
4. Hirvonen A, Tuimala J, Ollikainen T, Linnainmaa K, Kinnula V (2002) Manganese superoxide dismutase genotypes and asbestos-associated pulmonary disorders. Cancer Lett 178:71-74
5. Ho YS, Crapo JD (1998) Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase. FEBS Lett 229:256-260
6. Hori H, Ohmori O, Shinkai T, Kojima H, Okano C, Suzuki T, Nakamura J (2000) Manganese superoxide dismutase gene polymerphism and schizophrenia: relation to tardive dyskinesia. Neuropsychopharmacology 23:170-177
7. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 11:376-381
8. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ. Hammes P, Giardino I, Brownlee M (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787-790
9. Ohno T, Kawazu S, Tomono S (1996) Association analyses of the polymorphisms of angiotensin-converting enzyme and angiotensinogen genes with diabetic nephropathy in Japanese non-insulin-dependent diabetics. Metabolism 45:218-222
10. Shimoda-Matsubayashi S, Matsumine H, Kobayashi T, Nakagawa-Hattori Y, Shimizu Y, Mizuno Y (1996) Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. A predictive evidence for conformational change to influence mitochondrial transport and a study of allelic association in Parkinson's disease. Biochem Biophys Res Commun 226:561-565
11. Weisiger RA, Fridovich I (1973) Superoxide dismutase. Organelle specificity. J Biol Chem 248:3582-3592
12. West IC (2000) Radicals and oxidative stress in diabetes. Diabet Med 17:171-180