Osteogenic differentiation is selectively promoted by morphogenetic signals from chondrocytes and synergized by a nutrient rich growth environment

Connective Tissue Research

Volumn 44, Issue SUPPL. 1, 2003, Pages 85-91

  Gerstenfeld, Louis C ^a   Barnes, G L ^a   Shea, C M ^a,b   Einhorn, T A ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

BMP; Chondrocytes; Endochondral bone; Retinoblastoma

Indexed keywords

MESSENGER RNA; OSTEOCALCIN; OSTEOGENIC PROTEIN 1;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CELL DIFFERENTIATION; CHONDROGENESIS; COCULTURE; CONTROLLED STUDY; EMBRYO; ENRICHMENT CULTURE; FIBROBLAST; MESENCHYME CELL; NONHUMAN; OSTEOBLAST; RETINOBLASTOMA; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALIA;

EID: 0037242023     PISSN: 03008207     EISSN: None     Source Type: Journal    
DOI: 10.1080/03008200390152142     Document Type: Article

References (40)

1. Einhorn, T.A. (1998). The cell and molecular biology of fracture healing. Clin. Ortho. 355S:S7-S21.
2. Farnum, C.E., and Willsman, N.J. (1987). Morphologic stages of the terminal hypertrophic chondrocyte of growth plate cartilage. Anat. Res. 219:221-232.
3. Gerstenfeld, L.C., and Shapiro, F.D. (1996). Expression of bone specific genes by hypertrophic chondrocytes: Implications of a complex functionality for the growth plate. J. Cell. Biochem. 62:1-9.
4. Hunziker, E.B., and Schenk, R.K. (1989). Physiological mechanisms adopted by chondrocytes in regulating longitudinal bone growth in rats. J. Physiol. 414:55-71.
5. Johnson, R.L., and Tabin, C.J. (1997). Molecular models for vertebrate limb development. Cell 90:979-990.
6. Grigoriadis, A.E., Heersche, J.N., and Aubin, J.E. (1988). Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: Effect of dexamethasone. J. Cell Biol. 106:2139-2151.
7. Taylor, S.M., and Jones, P.A. (1979). Multiple new phenotypes induced in 10T 1/2 and 3T3 cells treated with 5-azacytodine. Cell 17:5771-5779.
8. Toma, C., Schaffer, J., Meazzini, M.C., Zurakowski, D., Nah, H.D., and Gerstenfeld, L.C. (1997). Developmental restriction of embryonic mesenchymal stem cells as characterized by their in vitro potential for differentation. J. Bone Miner. Res. 12:2024-2039.
9. Yamaguchi, A., and Kahn, A.J. (1991). Clonal osteogenic cell lines express myogenic and adipocytic developmental potential. Calcif. Tiss. Int. 49:221-225.
10. Baylink, D.J., Finkelman, R.D., and Mohan, S. (1993). Growth factors to stimulate bone formation. J. Bone Miner Res. 8(supp. 2): S565-S572.
11. Enomoto-Iwamoto, M., Iwamoto, M., Mukudai, Y., Kawakami, Y., Nohno, T., Higuchi, Y., Takemoto, S., Ohuchi, H., Noji, S., and Kurisu, K. (1998). Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J. Cell Biol. 140:409-418.
12. Hogan, B.L.M. (1996). Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes Dev. 10:1580-1594.
13. Karp, S.J., Schipani, E., St-Jacques, B., Hunzelman, J., Kronenberg, H., and McMahon, A.P. (2000). Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and-independent pathways. Development 127:543-548.
14. Murtaugh, L.C., Chyung, J.H., and Lassar, A.B. (1999). Sonic hedgehog promotes somotic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev. 2:225-237.
15. Nakamura, T., Aikawa, T., Enomoto-Iwamoto, M., Iwamoto, M., Higuchi, Y., Pacifici, M., Kinto, N., Yamaguchi, A., Noji, S., Kurisu, K., and Matsuya, T. (1997). Induction of osteogenic differentiation by hedgehog proteins. Biochem. Biophys. Res. Comm. 237:465-469.
16. Pathi, S., Rutenberg, J.B., Johnson, R.L., and Vortkamp, A. (1999). Interaction of IHH and BMP/noggin signaling during cartilage differentiation. Dev. Biol. 209:239-253.
17. Reddi, A.H., and Cunningham, N.S. (1993). Initiation and promotion of bone differentiation by bone morphogenetic proteins. J. Bone Miner Res. 8(supp. 2):S499-S502.
18. Shiang, R., Thompson, L.M., Zhu, Y.Z., Church, D.M., Fielder, T.J., Bocian, S.T., Winokur, S.T., and Wasmuth, J.J. (1994). Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 78:335-342.
19. Naski, M.C., and Ornitz, D.M. (1998). FGF signaling in skeletal development. Frontiers BioSci. 3:781-794.
20. St-Jacques, B., Hammerschmidt, M., and McMahon, A.P. (1999). Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13:2072-2086.
21. Wozney, J.M. (1989). Bone morphogenetic proteins. Progress in Growth Factor Research 1:267-280.
22. Kon, T., Cho, T.J., Aizawa, T., Yamazaki, M., Nooh, N., Graves, D., Gerstenfeld, L.C., and Einhorn, T.A. (2001). Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner. Res. 16:1004-1014.
23. Gerstenfeld, L.C., and Landis, W.J. (1991). Gene expression and extracellular matrix ultrastructure of a mineralizing chondrocyte cell culture system. J. Cell Biol. 112:501-513.
24. Gerstenfeld, L.C., Chipman, S.D., Glowacki, J., and Lian, J.B. (1987). Expression of differentiated function by mineralizing cultures of chicken osteoblasts. Dev. Biol. 122:49-60.
25. Yang, R., and Gerstenfeld, L.C. (1997). Structural analysis and characterization of tissue and hormonal responsive expression of the avian bone sialoprotein gene. J. Cell. Biochem. 64:77-93.
26. Kostenuik, P.J., Halloran, B.P., Morey-Halton, E.R., and Bikle, D.D. (1997). Skeletal unloading inhibits in vitro proliferation and differentiation of rat osteoprogenitor cells. Am. J. Physiol. 273:E1133-E1139.
27. Thomas, P. (1980). Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA 77:5201-5206.
28. Constantinides, P.G., Taylor, S.M., and Jones, P.A. (1978). Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides. Dev. Biol. 66:57-71.
29. Gerstenfeld, L.C., Cruceta, J., Shea, C.M., Sampath, K., Barnes, G.L., and Einhorn, T.A. (2002). Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells. J. Bone Miner. Res. 17:221-230.
30. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A., and Karsenty, G. (1997). Osf2/Cbfa1 a transcriptional activator of osteoblast differentiation. Cell 89:747-754.
31. Banerjee, C., McCabe, L.R., Choi, J.Y, Hiebert, S.W., Stein, J.L., Stein, G. S., and Lian, J.B. (1997). Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex. J. Cell Biochem. 66:1-8.
32. Harada, H., Tagashira, S., Fujiwara, M., Ogawa, S., Katsumata, T., Yamaguchi, A., Komori, T., and Nakatsuka, M. (1999). Cbfa1 isoforms exert functional differences in osteoblast differentiation. J. Cell Biochem. 274:6972-6978.
33. Asahina, I., Sampath, T.K., Nishimura, I., and Hauschka, P.V. (1993). Human osteogenic\protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J. Cell Biol. 123:921-933.
34. Onishi, T., Ishidou, Y., Nagamine, T., Yone, K., Imamura, T., Kato, M., Sampath, T.K., Dijke, P.T., and Sakou, T. (1998). Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Bone 22:605-612.
35. Bostrom, M.P.G. (1998). Expression of bone morphogenetic proteins in fracture healing. Clin. Orthop. 355(suppl):s116-s123.
36. Barnes, G.L., Kostenuik, P.J., Gerstenfeld, L.C., and Einhorn, T.A. (1999). Growth factor regulation of fracture repair. J. Bone Miner. Res. 14:1805-1815.
37. Cho, T.J., Gerstenfeld, L.C., and Einhorn, T.A. (2002). Differential temporal expression of members of the TGF-β superfamily during murine fracture healing. J. Bone Miner. Res. 17:513-520.
38. Fuchs, E., and Segre, J. (2000). Stem cells: A new lease on life. Cell 100:143-155.
39. Gurney, J.G., Severson, R.K., Davis, S., and Robison, L.L. (1995). Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer 75:2186-2195.
40. Thomas, D.M., Carty, S.A., Piscopo, D.M., Lee, J.S., Wang, W.F., Forrester, W.C., and Hinds, P.W. (2001). The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol. Cell 2:303-316.