The role of androgen therapy

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 17, Issue 1, 2003, Pages 165-175

  Davis, Susan R ^a,b   Burger, Henry G ^b,c  

^a Jean Hailes Foundation   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Dehydroepiandrosterone sulphate; Free testosterone; Hypopituitarism; Libido; Premature ovarian failure; Sex hormone binding globulin; Testosterone; Well being.

Indexed keywords

ALBUMIN; ANDROGEN; ANDROSTANOLONE; ANDROSTENEDIOL; ANDROSTENEDIONE; CONJUGATED ESTROGEN; CORTICOSTEROID; ESTRADIOL; ESTRADIOL VALERATE; ESTROGEN; GLUCOCORTICOID; GONADOTROPIN; METHYLTESTOSTERONE; PLACEBO; PRASTERONE; PRASTERONE SULFATE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TESTOSTERONE UNDECANOATE; TIBOLONE;

ACNE; ADRENAL INSUFFICIENCY; ALOPECIA; ANDROGEN BLOOD LEVEL; ANDROGEN THERAPY; BIOAVAILABILITY; CARDIOVASCULAR DISEASE; CLINICAL FEATURE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); DISTRESS SYNDROME; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG MEGADOSE; FATIGUE; FEMALE; HORMONE BLOOD LEVEL; HORMONE DEFICIENCY; HORMONE DETERMINATION; HUMAN; HYPERTROPHY; HYPOPITUITARISM; LARYNX DISORDER; LIBIDO DISORDER; LIPID BLOOD LEVEL; MOTIVATION; NONHUMAN; PREMATURE OVARIAN FAILURE; REVIEW; SIDE EFFECT; TESTOSTERONE BLOOD LEVEL; TREATMENT INDICATION; WELLBEING; ANDROGEN DEFICIENCY; BREAST CANCER; HIRSUTISM; MENOPAUSAL SYNDROME; TREATMENT CONTRAINDICATION;

EID: 0037240558     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-690X(02)00078-7     Document Type: Review

References (35)

1. Davis SR & Burger HG. Androgens and the postmenopausal woman. Journal of Clinical Endocrinology and Metabolism 1996; 81: 2759-2763.
2. Davis SR & Burger HG. The rationale for physiological testosterone replacement in women. Baillière's Clinical Endocrinology and Metabolism 1998; 12: 391-405.
3. Davis SR. Androgen treatment in women. Medical Journal of Australia 1999; 170: 545-549
4. Yen SSC. In Yen SSc, Jaffe RB & Barbieri RL (eds) Reproductive Endocrinology, 4th edn. p 479, Philadelphia: WB Saunders Company, 1999.
5. Burger HG. Androgen production in women. Fertility and Sterility 2002; 77 (supplement 4): 3-5.
6. Orentreich N, Brind JL, Rizer RL et al. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. Journal of Clinical Endocrinology and Metabolism 1984; 59: 551-555.
7. Burger HG, Dudley EC, Cui J et al. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. Journal of Clinical Endocrinology and Metabolism 2000; 85: 2832-2838.
8. Miller KK, Sesmilo G, Schiller A et al. Androgen insufficiency in women with hypopituitarism. Journal of Clinical Endocrinology and Metabolism 2001; 561-567.
9. Couzinet B, Meduri G, Lecce M et al. The post menopausal ovary is not a major androgen producing gland. Journal of Clinical Endocrinology and Metabolism 2001; 86: 5060-5065.
10. Zumoff B, Strain GW, Miller LK et al. Twenty-four-hour plasma testosterone concentration declines with age in normal menopausal women. Journal of Clinical Endocrinology and Metabolism 1995; 80: 1429-1430.
11. Mathur RS, Landgreve SC, Moody LO et al. The effect of estrogen treatment on plasma concentrations of steroid hormones, gonadotropins, prolactin and sex hormone-binding globulin in post-menopausal women. Maturitas 1985; 7: 129-133.
12. Simon J, Klaiber E, Wiita B et al. Differential effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion and endogenous androgen bioavailability in postmenopausal women. Menopause: The Journal of the American Menopause Society 1999; 6: 138-146.
13. Davis SR, McCloud PI, Strauss BJG et al. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995; 21: 227-236.
14. Studd JWW, Colins WP & Chakravarti S. Estradiol and testosterone implants in the treatment of psychosexual problems in postmenopausal women. British Journal of Obstetrics and Gynaecology 1977; 84: 314-315.
15. Sherwin BB, Gelfand MM & Bredner W. Androgen enhances sexual motivation in females: A prospective, crossover study of sexual steroid administration in the surgical menopause. Psychosomatic Medicine 1985; 47: 339-351.
16. Sherwin BB & Gelfand MM. Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause. American Journal of Obstetrics and Gynaecology 1985; 151: 153-160.
17. Burger HG, Hailes J, Menelaus M et al. The management of persistent menopausal symptoms with estradiol-testosterone implants: Clinical, lipid and hormonal results. Maturitas 1984; 6: 351-358.
18. Burger HG, Hailes J, Nelson J & Menelaus M. Effect of combined implants of estradiol and testosterone on libido in postmenopausal women. British Medical Journal 1987; 294: 936-937.
19. Shiften JL, Braunsten GD, Simon JA et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. New England Journal of Medicine 2000; 343: 682-688.
20. Arlt W, Callies F, Christoph et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency. New England Journal of Medicine 1999; 341: 1013-1020.
21. Raisz LG, Wiita B, Artis A et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers on bone formation and resorption in postmenopausal women. Journal of Clinical Endocrinology and Metabolism 1996; 81: 37-43.
22. Watts JB, Notelovitz M, Timmons MC et al. Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause. Obstetrics and Gynecology 1995; 85: 529-537.
23. Bachmann G, Bancroft J, Braunstein G et al. Female androgen insufficiency: The Princeton consensus statement on definition, classification, and assessment. Fertility and Sterility 2002; 77: 660-665.
24. Kaplan HS & Owett T. The female androgen insufficiency syndrome. Journal of Sex and Marital Therapy 1993; 19: 3-24.
25. Bachman GA, Leiblum SR, Kemmann E et al. Sexual expression and its determinants in the post-menopausal woman. Maturitas 1984; 6: 19-29.
26. Cutler WB, Garcia C-R, Huggins GR & Preti G. Sexual behavior and steroid levels among gynecologically premature premenopausal women. Fertility and Sterility 1986; 48: 496-502.
27. Bancroft J, Sherwin B, Alexander GM et al. Oral contraceptives, androgens and the sexuality of young women. II. The role of androgens. Archives of Sexual Behavior 1991; 20: 121-135.
28. Dennerstein L, Dudley EC, Hopper JL et al. A prospective population-based study of menopausal symptoms. Obstetrics and Gynecology 2000; 96: 351-358.
29. Dennerstein L, Randolph J, Taffe J et al. Hormones, mood, sexuality and the menopausal transition. Fertility and Sterility 2002; 77 (supplement 4): 42-48.
30. Lobo RA. Androgens in postmenopausal women: Production, possible role and replacement options. Obstetrical and Gynecological Survey 2001; 56: 361-376.
31. Buckler HM, Robertson WR & Wu FCW. Which androgen replacement therapy for women? Journal of Clinical Endocrinology and Metabolism 1998; 83: 3920-3924.
32. Davis SR. Effects of tibolone on mood and libido. Menopause 2002; 9: 162-170.
33. Worboys S, Kotsopoulos D, Teede H et al. Parental testosterone improves endothelium-dependent and independent vasodilation in postmenopausal women already receiving estrogen. Journal of Clinical Endocrinology and Metabolism 2001; 86: 158-161.
34. Bernini GP, Sgro M, Moretti A et al. Endogenous androgens and carotid intimal-medial thickness in women. Journal of Clinical Endocrinology and Metabolism 1999; 84: 2008-2012.
35. Zhou J, Ng S, Adesanya-Famuiyao et al. Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression. FASEB Journal 2000; 14: 1725-1730.