Chimeric human/murine monoclonal IgM antibodies to HIV-1 Nef antigen expressed on chronically infected cells

Microbiology and Immunology

Volumn 47, Issue 3, 2003, Pages 247-253

  Kawai, Masahiro ^a   He, Lianying ^a   Kawamura, Takeshi ^a   Omoto, Shinya ^b   Fujii, Yoichi R ^b   Okada, Noriko ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Chimeric monoclonal antibody; Chronic infection; IgM; Nef

Indexed keywords

CD59 ANTIGEN; CHIMERIC ANTIBODY; COMPLEMENT; GANGLIOSIDE ANTIBODY; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN M ANTIBODY; IMMUNOGLOBULIN MU CHAIN; MONOCLONAL ANTIBODY; NEF PROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CHROMOSOME; COMPLEMENT SYSTEM; CONTROLLED STUDY; CYTOLYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGLOBULIN PRODUCTION; MEMBRANE; MOUSE; NONHUMAN; SPLEEN CELL;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE; RNA VIRUSES;

EID: 0037240435     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2003.tb03384.x     Document Type: Article

References (23)

1. Butera, S.T., Roberts, B.D., and Folks, T.M. 1993. Regulation of HIV-1 expression by cytokine networks in a CD4+ model of chronic infection. J. Immunol. 150: 625-634.
2. Cole, J.L., Housley, G.A., Jr., Dykman, T.R., MacDermott, R.P., and Atkinson, J.P. 1985. Identification of an additional class of C3-binding proteins of human peripheral blood leukocytes and cell lines. Proc. Natl. Acad. Sci. U.S.A. 82: 859-863.
3. Davies, A., Simmons, D., Hale, G., Harrison, R.A., Tighe, H., Lachmann, P.J., and Waldmann, H. 1989. CD59, an ly-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J. Exp. Med. 170: 637-654.
4. + T lymphocytes and for the blocking of the Nef function by anti-Nef antibodies. Vaccine 11: 837-847.
5. Fujii, Y., Nishino, Y., Nakaya, T., Tokunaga, K., and Ikuta, K. 1993. Expression of human immunodeficiency virus type 1 Nef antigen on the cell surface of acutely and persistently infected human T cells. Vaccine 11: 1240-1246.
6. Holguin, M.H., Fredrick, L.R., Bernshaw, N.J., Wilcox, L.A., and Parker, C.J. 1989. Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria. J. Clin. Invest. 84: 7-17.
7. Ishida, I., Yoshida, H., and Tomizuka, K. 1998. Production of a diverse repertoire of human antibodies in genetically engineered mice. Microbiol. Immunol. 42: 143-150.
8. Kikukawa, R., Koyanagi, Y., Harada, S., Kobayashi, N., Hatanaka, M., and Yamamoto, N. 1896. Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in clone cells of human leukemic T-cell line MOLT-4. J. Virol. 57: 1159-1162.
9. Koltman, M.E., Kim, S., Buchinder, A., Derossi, A., Baltimore, D., and Wong-Staal, F. 1992. Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc. Natl. Acad. Sci. U.S.A. 88: 5011-5015.
10. Lederman, M.M., Purvis, S.F., Walter, E.I., Carey, J.T., and Medof, M.E. 1989. Heightened complement sensitivity related to diminished expression of decay-accelerating factor. Proc. Natl. Acad. Sci. U.S.A. 86: 4205-4209.
11. Matsushita, S., Robert-Guroff, M., Rusche, J., Koito, A., Hattori, T., Hoshino, H., Javaherinan, K., Takatsuki, K., and Putney, S. 1988. Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope. J. Virol. 62: 2107-2114.
12. Medof, E., Kinoshita T., and Nussenzweig, V. 1984. Inhibition of complement activation on the surface of cells after incorporation of decay accelerating factor (DAF) into their membranes. J. Exp. Med. 160: 1558-1578.
13. Okada, H., Tanaka, H., and Okada, N. 1983. Prevention of complement activation on the homologous cell membrane of nucleated cells as well as erythrocytes. Eur. J. Immunol. 13: 340-344.
14. Okada, N., Harada, R., Fujita, T., and Okada, H. 1989. A novel membrane glycoprotein capable of inhibiting membrane attack by homologous complement. Int. Immunol. 1: 205-208.
15. Okada, N., and Okada, H. 1999. Human IgM antibody therapy for HIV-1 infection. Microbiol. Immunol. 43: 729-736.
16. Okada, N., Wu, X.S., Mizokami, M., Irie, R.F., and Okada, H. 1999. Human monoclonal antibody to ganglioside GM2 and complement suppress virus propagation in ex vivo cultures of lymphocytes from HIV-1 infected patients. Microbiol. Immunol. 43: 723-727.
17. Otake, K., Fujii, Y., Nakaya, T., Nishino, Y., Zhong, Q., Fujinaga, K., Kameoka, M., Ohki, K., and Ikuta, K. 1994. The carboxy-terminal region of HIV-1 Nef protein is a cell surface domain that can interact with CD4+ T cells. J. Immunol. 153: 5826-5837.
18. Otake, K., Fujii, Y., Tashiro, M., Adachi, A., and Kitoh, J. 1997. Epitope mapping of murine monoclonal antibodies against human Immunodeficiency virus type 1 Nef. Exp. Anim. 46: 53-58.
19. Sugita, Y., Nakano, Y., and Tomita, M. 1988. Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. J. Biochem. 104: 633-637.
20. Tomizuka, K., Yoshida, H., Uejima, H., Kugoh, H., Sato, K., Ohguma, A., Hayasaka, M., Hanaoka, K., Oshima, M., and Ishida, I. 1997. Functional expression and germline transmission of a human chromosome fragment in chimaeric mice. Nature Genetics 16: 133-143.
21. Wu, X.S., Okada, N., Iwamori, M., and Okada, H. 1996. IgM natural antibody against an asialo-oligosaccharide, gangliotetraose (Gg4), sensitizes HIVinfected cells for cytolysis by homologous complement. Int. Immunol. 8: 153-158.
22. Wu, X.S., Okada, N., Momota, H., Irie, R.F., and Okada, H. 1999. Complement mediated anti-HIV-1 effect induced by human IgM mAb against ganglioside GM2. J. Immunol. 162: 533-539.
23. Yamada, T., and Iwamoto, A. 1999. Expression of a novel Nef epitope on the surface of HIV type 1 infected cells. AIDS Res. Hum. Retrovir. 15: 1001-1009.