Mechanisms contributing to the vaso-active effects of prilocaine in human skin

Anaesthesia

Volumn 58, Issue 1, 2003, Pages 6-10

  Newton, D J ^a   Sur, E L ^a   Khan, F ^a   McLeod, G A ^a   Belch, J J F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Anaesthetics local; prilocaine; Equipment; laser Doppler; Measurement techniques; blood flow; Microcirculation; capillaries

Indexed keywords

ACETYLSALICYLIC ACID; LOCAL ANESTHETIC AGENT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PRILOCAINE; PROSTACYCLIN SYNTHASE; SODIUM CHLORIDE;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG RESPONSE; ENZYME INHIBITION; FOREARM; HUMAN; HUMAN EXPERIMENT; LASER DOPPLER FLOWMETRY; MALE; MEDIATOR RELEASE; NORMAL HUMAN; SIGNAL TRANSDUCTION; SKIN; SKIN BLOOD FLOW;

ADOLESCENT; ADULT; ANESTHETICS, LOCAL; ASPIRIN; DRUG INTERACTIONS; FOREARM; HUMANS; INJECTIONS, INTRADERMAL; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PRILOCAINE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SKIN; VASODILATION; VASODILATOR AGENTS;

EID: 0037237691     PISSN: 00032409     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2044.2003.02954.x     Document Type: Article

References (17)

1. Scott DB, Jebson PJR, Braid DP, Örtengren B, Frisch P. Factors affecting plasma levels of lignocaine and prilocaine. British Journal of Anaesthesia 1972; 44: 1040-9.
2. Bartholomew K, Sloan JP. Prilocaine for Bier's block: How safe is safe? Archives of Emergency Medicine 1990; 7: 189-95.
3. Hjelm M, Holmdahl MH. Clinical chemistry of prilocaine and clinical evaluation of methaemoglobin by this agent. Acta Anaesthesiologica Scandinavica 1965; 16 (Suppl.): 161-70.
4. Covino BG. Pharmacology of local anaesthetic agents. British Journal of Anaesthesia 1986; 58: 701-16.
5. Willatts DG, Reynolds F. Comparison of the vasoactivity of amide and ester local anaesthetics. British Journal of Anaesthesia 1985; 57: 1006-11.
6. Essex TJH, Byrne PO. A laser Doppler scanner for imaging blood flow in skin. Journal of Biomedical Engineering 1991; 13: 189-94.
7. Newton DJ, Burke D, Khan F et al. Skin blood flow changes in response to intradermal injection of bupivacaine and levobupivacaine, assessed by laser Doppler imaging. Regional Anesthesia and Pain Medicine 2000; 25: 626-31.
8. Clough GF. Role of nitric oxide in the regulation of microvascular perfusion in human skin in vivo. Journal of Physiology 1999; 516: 549-57.
9. Kajimoto Y, Rosenberg ME, Kyttä J et al. Anaphylactoid skin reactions after intravenous regional anaesthesia using 0.5% prilocaine with or without preservative - A double-blind study. Acta Anaesthesiologica Scandinavica 1995; 39: 782-4.
10. Hamilton JT, Zhou Y, Gelb AW. Paraben preservatives but not succinylcholine are cerebral vasodilators in vitro. Anesthesiology 1990; 73: 1252-7.
11. Rang HP, Dale MM, Ritter JM. Pharmacology, 3rd edn. New York: Churchill Livingstone, 1996.
12. Hollmann MW, DiFazio CA, Durieux ME. Ca-signaling G-protein-coupled receptors: A new site of local anesthetic action? Regional Anesthesia and Pain Medicine 2001; 26: 565-71.
13. Hollmann MW, Wieczorek KS, Smart M, Durieux ME. Epidural anesthesia prevents hypercoagulation in patients undergoing major orthopedic surgery. Regional Anesthesia and Pain Medicine 2001; 26: 215-22.
14. Heavner JE, Shi B, Pitkänen M. Nitric oxide synthesis inhibition modifies the cardiotoxicity of tetracaine and lidocaine. Anesthesia and Analgesia 1999; 88: 717-22.
15. Nishio E, Watanabe Y. Aspirin and salicylate enhances the induction of inducible nitric oxide synthase in cultured rat smooth muscle cells. Life Sciences 1998; 63: 429-39.
16. Lau CS, Khan F, McLaren M, Bancroft A, Walker M, Belch JJF. The effects of thromboxane receptor blockade on platelet aggregation and digital skin blood flow in patients with secondary Raynaud's syndrome. Rheumatology International 1991; 11: 163-8.
17. Iida H, Watanabe Y, Dohi S, Ishiyama T. Direct effects of ropivacaine and bupivacaine on spinal pial vessels in canine: Assessment with closed spinal window technique. Anesthesiology 1997; 87: 75-81.