Nitric oxide synthesis inhibition modifies the cardiotoxicity of tetracaine and lidocaine

Anesthesia and Analgesia

Volumn 88, Issue 4, 1999, Pages 717-722

  Heavner, James E ^a,c   Shi, Bing ^a   Pitkänen, Mikko ^a,b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Toolo Hospital   (Finland)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE METHYL ESTER; LIDOCAINE; NITRIC OXIDE SYNTHASE INHIBITOR; TETRACAINE;

ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTERIAL PRESSURE; ARTICLE; ASYSTOLE; BLOOD GAS; BODY WEIGHT; CARDIOTOXICITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG TRANSFORMATION; ELECTROCARDIOGRAM; GRAND MAL EPILEPSY; HEART LEFT VENTRICLE OVERLOAD; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NERVE BLOCK; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT;

EID: 0032897302     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199904000-00003     Document Type: Article

References (16)

1. de Jong RH. Local anesthetics. St. Louis, MO: Mosby-Year Book, 1994.
2. Somlyo AP, Somlyo AV. Vascular smooth muscle. II. Pharmacology of normal and hypertensive vessels. Pharmacol Rev 1970;22:249-353.
3. Zahradnikova A, Krizanova O. Nitric oxide and its effects on the calcium transport systems in the myocardium. Gen Physiol Biophys 1997;16:197-214.
4. Shi B, Heavner JE. Modification of bupivacaine toxicity by non-selective versus neuronal nitric oxide synthesis inhibition. Anesth Analg 1997;84:804-9.
5. Heavner JE, Shi, B, Pitkänen M. Effects of nitric oxide synthesis inhibition with or without nitric oxide inhalation on responses to systemic cocaine administration in rats. Life Sci 1995;57: 715-28.
6. G-nitro-L-arginine methyl ester in conscious, Long Evans rats. Br J Pharmacol 1990;101: 625-31.
7. Tucker GT, Mather LE. Clinical pharmacokinetics of local anesthetics. Clin Pharmacokinet 1979;4:241-78.
8. Park GB, Erdtmansky PE, Brown RR, et al. Analysis of mepivacaine, bupivacaine, etidocaine lidocaine, and tetracaine. J Pharm Sci 1980;69:603-5.
9. Huang M, Leblanc ML, Hester RL. Systemic and regional hemodynamics after nitric oxide synthase inhibition: role of a neurogenic mechanism. Am J Physiol 1994;267:R84-8.
10. Minami N, Imai Y, Hashimoto J-I, Abe K. The role of nitric oxide in the baroreceptor-cardiac reflex in conscious Wistar rats. Am J Physiol 1995;269:H851-5.
11. Frank MW, Harris KR, Ahlin KA, Klocke FJ. Endothelium-derived relaxing factor (nitric oxide) has a tonic vasodilating action on coronary collateral vessels. J Am Coll Cardiol 1996;27: 658-63.
12. Szabó C. Physiological and pathophysiological roles of nitric oxide in the central nervous system. Brain Res Bull 1996;41: 131-41.
13. 2+ and cyclic AMP. Acta Pharmacol Toxicol (Copenh) 1972;31:321-36.
14. Armour JA, Smith FM, Losier AM, et al. Modulation of intrinsic cardiac neuronal activity by nitric oxide donors induces cardiodynamic changes. Am J Physiol 1995;268:R403-13.
15. Deleted in proof.
16. Witkin JM, Tortella FA. Modulators of N-methyl-D-aspartate protect against diazepam-or phenobarbital-resistant cocaine convulsions. Life Sci 1991;48:PL51-6.