Tissue Doppler echocardiography in patients with thalassaemia detects early myocardial dysfunction related to myocardial iron overload

European Heart Journal

Volumn 24, Issue 1, 2003, Pages 113-119

  Vogel, Michael ^a,c   Anderson, L J ^b   Holden, S ^a   Deanfield, J E ^a   Pennell, D J ^b   Walker, J M ^a  

^a UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

^c MIDDLESEX HOSPITAL   (United Kingdom)

Author keywords

Echocardiography; Heart failure and thatassaemia; Magnetic resonance imaging

Indexed keywords

DEFEROXAMINE; FERRITIN; IRON;

ADOLESCENT; ADULT; BLOOD FLOW VELOCITY; CARDIOMYOPATHY; CONFERENCE PAPER; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE WALL MOTION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE INJURY; HEART RIGHT VENTRICLE; HUMAN; INTERMETHOD COMPARISON; IRON OVERLOAD; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; THALASSEMIA MAJOR;

ADOLESCENT; ADULT; BETA-THALASSEMIA; CARDIOMYOPATHIES; CHELATING AGENTS; DEFEROXAMINE; ECHOCARDIOGRAPHY, DOPPLER; HUMANS; IRON OVERLOAD; MAGNETIC RESONANCE IMAGING; VENTRICULAR DYSFUNCTION; VENTRICULAR FUNCTION;

EID: 0037236871     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0195-668X(02)00381-0     Document Type: Conference Paper

References (20)

1. Lau KC, Li AMC, Hui PW et al. Left ventricular function in β-thalassemia major. Arch Dis Child 1989;64(20):1046-51.
2. Hofibfand AV. Diagnosing myocardial iron overload. Eur Heart J 2001;22:2140-1.
3. Brili SV, Tzounou AI, Castelanos SS et al. The effect of iron overload in the hearts of patients with beta-thalassemia. Clin Cardiol 1997;20:541-6.
4. Leon MB, Borer JS, Bacharach LS et al. Detection of early cardiac dysfunction in patients with severe betathalassemia and chronic iron overload. N Engl J Med 1979; 301:1143-8.
5. Trikas A, Tentolouris K, Katsimaklis G et al. Exercise capacity in patients with beta-thalassemia major: relation to left ventricular size and atrial size and function. Am Heart J 1998;136:988-90.
6. Mavrogeni SI, Gotis ED, Markussis V et al. T2 relaxation time study of iron overload in b-thalassemia. MAGMA 1998; 6:7-12.
7. Anderson LJ, Holden S, Davis B et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001;22:2171-9.
8. Isaaz K, Thompson A, Ethevenot G et al. DoppLer echocar-diographic measurement of low velocity motion of the left ventricular posterior wall. Am J Cardiol 1989;64:66-75.
9. Vogel M, Sponring J, Cullen S et al. Regional wall motion and abnormalities of electrical depolarisation and repolarisation in patients after surgical repair of tetralogy of Fallot. Circulation 2001;103:1669-73.
10. McDicken WN, Sutherland GR, Moran CM et al. Colour Doppler velocity imaging of the myocardium. Ultrasound Med Biol 1992;18:651-4.
11. Pattynama PM, de Roos A, van der Wall EE et al. Evaluation of cardiac function with magnetic resonance imaging. Am Heart J 1994;128:595-607.
12. Hardy PA. Transverse relaxation rate enhancement caused by magnetic particulates. Magn Reson Imaging 1989; 7:265-75.
13. Valdez-Cruz LM, Reinecke C, Rutkowski M et al. Preclinical abnormal segmental cardiac manifestations of thalassemia major in children on transfusion-chelation therapy: echocar-diographic alterations of left ventricular posterior wall contraction and relaxation patterns. Am Heart J 1982; 103:505-11.
14. Palka P, Lange A, Fleming AD et al. Doppler tissue imaging: myocardial wall motion velocities in normal subjects. J Am Soc Echocardiogr 1995;8:659-68.
15. Kremastinos DT, Tsiapras DP, Tsetos GA et al. Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Circulation 1993;88:1127-35.
16. Barosi G, Arbustine E, Gavazzi A et al. Myocardial iron grading by endomyocardial biopsy. A clinico-pathologic study on iron overloaded patients. Eur J Haematol 1989; 42:382-8.
17. Liu P, Henkelman M, Joshi J et al. Quantification of cardiac and tissue iron by nuclear magnetic resonance relaxometry in a novel murine thalassemia-cardiac iron overload model. Can J Cardiol 1996;12:155-64.
18. Fitchett DH, Coltart DJ, Littler WA et al. Cardiac involvement in secondary haemochromatosis: a catheter biopsy study and analysis of myocardium. Cardiovasc Res 1980; 14:719-24.
19. Lattanzi F, Bellotti P, Picano E et al. Quantitative ultrasonic analysis of myocardium in patients with thalassemia major and iron overload. Circulation 1993;87:748-54.
20. Suarez WA, Snyder SA, Berman BB et al. Preclinical cardiac dysfunction in transfusion-dependent children and young adults detected with low-dose dobutamine stress echocardiography. J Am Soc Echocardiogr 1998;11:948-95.