Effects of epinephrine and phosphodiesterase III inhibitors on bupivacaine-induced myocardial depression in guinea-pig papillary muscle

British Journal of Anaesthesia

Volumn 90, Issue 1, 2003, Pages 66-71

  Azuma, M ^a   Yamane, M ^a   Tachibana, K ^a   Morimoto, Y ^a   Kemmotsu, O ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anaesthetics local, bupivacaine; Enzymes, phosphodiesterase, inhibition; Nerve, transmission; Sympathetic nervous system, epinephrine

Indexed keywords

ADRENALIN; AMRINONE; BUPIVACAINE; MILRINONE; PHOSPHODIESTERASE INHIBITOR; POTASSIUM; ROPIVACAINE; SEVOFLURANE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CARDIOTOXICITY; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GUINEA PIG; HEART CONTRACTION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART PAPILLARY MUSCLE; HEART REPOLARIZATION; MYOCARDIAL DISEASE; NONHUMAN; PRIORITY JOURNAL; SODIUM CURRENT;

EID: 0037232146     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeg025     Document Type: Article

References (15)

1. Clarkson CW, Hondeghem LM. Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 1985; 62: 396-405
2. Coyle DE, Sperelakis N. Bupivacaine and lidocaine blockade of calcium-mediated slow action potentials in guinea pig ventricular muscle. J Pharmacol Exp Ther 1987; 242: 1001-5
3. + current but not the inward rectifier in rat ventricular myocytes. J Pharmocol Exp Ther 1990; 255: 1038-46
4. Neustein S, Sampson I, Dimich I, Shiang H, Tatu J. Milrinone is superior to epinephrine as treatment of myocardial depression due to ropivacaine in pigs. Can J Anaesth 2000; 47: 1114-18
5. Endoh M, Yanagisawa T, Taira N, Blinks JR. Effects of new inotropic agents on cyclic nucleotide metabolism and calcium transients in canine ventricular muscle. Circulation 1986; 73 (suppl III): III 117-33
6. Prorok M, Sukumaran DK, Lawrence DS. The cyclic AMP-dependent protein kinase from bovine cardiac muscle is a homoserine kinase. J Biol Chem 1989; 264: 17727-33
7. Lejemtel TH, Keung E, Sonnenblick EH, et al. Amrinone: a new non-glycosidic, non-adrenergic cardiotonic agent effective in the treatment of intractable myocardial failure in man. Circulation 1979; 59: 1098-104
8. Lindgren L, Randell T, Suzuki N, Kyttä J, Yli-Hankala A, Rosenberg PH. The effect of amrinone on recovery from severe bupivacaine intoxication in pigs. Anesthesiology 1992; 77: 309-15
9. 2+ and related ions on the cardiac action of milrinone. J Cardiovasc Pharmacol 1988; 11: 591-600
10. Mörner SEJN, Arlock P. Mechanical and electrophysiological effects of milrinone on the force-frequency relationship in mammalian myocardium. Acta Physiol Scand 1994; 150: 125-32
11. Azuma M, Matsumura C, Kemmotsu O. The effects of sevoflurane on contractile and electrophysiologic properties in isolated guinea pig papillary muscles. Anesth Analg 1996; 82: 486-91
12. K) in guinea pig ventricular myocytes. Pflügers Arch 1987; 410: 217-19
13. Yazawa K, Kameyama M. Mechanism of receptor-mediated modulation of the delayed outward potassium current in guinea-pig ventricular myocytes. J Physiol 1990; 421: 135-50
14. Uemura H, Sakamoto N, Nakaya H. Electropharmacological effects of UK-1745, a novel cardiotonic drug, in guinea-pig ventricular myocytes. Eur J Pharmacol 1999; 383: 361-71
15. Saitoh K, Hirabayashi Y, Shimizu R, Fukuda H. Amrinone is superior to epinephrine in reversing bupivacaine-induced cardiovascular depression in sevoflurane-anesthetized dogs. Anesthesiology 1995; 83: 127-33