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Volumn 383, Issue 3, 1999, Pages 361-371

Electropharmacological effects of UK-1745, a novel cardiotonic drug, in guinea-pig ventricular myocytes

Author keywords

Ca2+ channel; Cardiotonic drug; Milrinone; UK 1745

Indexed keywords

2 AMINOMETHYL 2,3,7,8 TETRAHYDRO 2,3,5,8,8 PENTAMETHYL 6H FURO[2,3-E]INDOL 7 ONE; CALCIUM CHANNEL; CARDIOTONIC AGENT; CYCLIC AMP; HISTAMINE; ISOPRENALINE; MILRINONE; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0032786686     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00651-2     Document Type: Article
Times cited : (3)

References (43)
  • 1
    • 0024333650 scopus 로고
    • Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG212CI, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea pig heart
    • Brunkhorst D., Leyden H., Meyer W., Nigbur R., Schmidt-Schumacher C., Scholz H. Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG212CI, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea pig heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 339:1989;575-583.
    • (1989) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.339 , pp. 575-583
    • Brunkhorst, D.1    Leyden, H.2    Meyer, W.3    Nigbur, R.4    Schmidt-Schumacher, C.5    Scholz, H.6
  • 2
    • 0024632078 scopus 로고
    • β-Adrenergic blocking drugs in the treatment of congestive heart failure
    • Charlap S., Lichstein E., Frishman W.H. β-Adrenergic blocking drugs in the treatment of congestive heart failure. Med. Clin. North Am. 73:1989;373-385.
    • (1989) Med. Clin. North Am. , vol.73 , pp. 373-385
    • Charlap, S.1    Lichstein, E.2    Frishman, W.H.3
  • 3
    • 0028092116 scopus 로고
    • A randomized trial of beta-blockade in heart failure: The Cardiac Insufficiency Bisoprolol Study (CIBIS)
    • A randomized trial of beta-blockade in heart failure: the Cardiac Insufficiency Bisoprolol Study (CIBIS). Circulation. 90:1994;1665-1673.
    • (1994) Circulation , vol.90 , pp. 1665-1673
  • 4
    • 0013932912 scopus 로고
    • The effects of beta adrenergic blockade on patterns of urinary sodium excretion: Studies in normal subjects and in patients with heart disease
    • Epstein S.E., Braunwald E. The effects of beta adrenergic blockade on patterns of urinary sodium excretion: studies in normal subjects and in patients with heart disease. Ann. Intern. Med. 65:1966;20-27.
    • (1966) Ann. Intern. Med. , vol.65 , pp. 20-27
    • Epstein, S.E.1    Braunwald, E.2
  • 6
    • 0018733531 scopus 로고
    • Calculator programs for computing the composition of solution containing multiple metals and legend used for experiments in skinned muscle cells
    • Fabiato A., Fabiato F. Calculator programs for computing the composition of solution containing multiple metals and legend used for experiments in skinned muscle cells. J. Physiol. (Paris). 75:1979;463-505.
    • (1979) J. Physiol. (Paris) , vol.75 , pp. 463-505
    • Fabiato, A.1    Fabiato, F.2
  • 7
    • 0025091033 scopus 로고
    • Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells
    • Fischmeister R., Hartzell H.C. Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells. Mol. Pharmacol. 38:1990;426-433.
    • (1990) Mol. Pharmacol. , vol.38 , pp. 426-433
    • Fischmeister, R.1    Hartzell, H.C.2
  • 8
    • 0023797004 scopus 로고
    • 2+ activation and the inotropic effect of pimobendan: Comparison with milrinone
    • 2+ activation and the inotropic effect of pimobendan: comparison with milrinone. Circ. Res. 63:1988;911-922.
    • (1988) Circ. Res. , vol.63 , pp. 911-922
    • Fujino, K.1    Sperelakis, N.2    Solaro, R.J.3
  • 9
    • 0019441262 scopus 로고
    • Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
    • Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:1981;85-100.
    • (1981) Pflügers Arch. , vol.391 , pp. 85-100
    • Hamill, O.P.1    Marty, A.2    Neher, E.3    Sakmann, B.4    Sigworth, F.J.5
  • 10
    • 0028790285 scopus 로고
    • SD-3212, a new class I and IV antiarrhythmic drug: A potent inhibitor of the muscarinic acetylcholine-receptor-operated potassium current in guinea-pig atrial cells
    • Hara Y., Nakaya H. SD-3212, a new class I and IV antiarrhythmic drug: a potent inhibitor of the muscarinic acetylcholine-receptor-operated potassium current in guinea-pig atrial cells. Br. J. Pharmacol. 116:1995;2750-2756.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2750-2756
    • Hara, Y.1    Nakaya, H.2
  • 11
    • 0022492587 scopus 로고
    • Effects of OPC-8212, a new positive inotropic agent, on canine ventricular arrhythmias
    • Hashimoto K., Mitsuhashi H. Effects of OPC-8212, a new positive inotropic agent, on canine ventricular arrhythmias. Br. J. Pharmacol. 88:1986;915-921.
    • (1986) Br. J. Pharmacol. , vol.88 , pp. 915-921
    • Hashimoto, K.1    Mitsuhashi, H.2
  • 14
    • 0020376510 scopus 로고
    • Calcium tolerant ventricular myocytes prepared by preincubation in a "kB medium"
    • Isenberg G., Klockner U. Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium" Pflügers Arch. 395:1982;6-18.
    • (1982) Pflügers Arch. , vol.395 , pp. 6-18
    • Isenberg, G.1    Klockner, U.2
  • 15
    • 0022381201 scopus 로고
    • On the mechanism of β-adrenergic regulation of the Ca channel in the guinea-pig heart
    • Kameyama M., Hofmann F., Trautwein W. On the mechanism of β-adrenergic regulation of the Ca channel in the guinea-pig heart. Pflügers Arch. 405:1985;285-293.
    • (1985) Pflügers Arch. , vol.405 , pp. 285-293
    • Kameyama, M.1    Hofmann, F.2    Trautwein, W.3
  • 18
    • 0014266599 scopus 로고
    • Antiarrhythmic activity of some isoquinoline derivatives determined by a rapid screening procedure in the mouse
    • Lawson J.W. Antiarrhythmic activity of some isoquinoline derivatives determined by a rapid screening procedure in the mouse. J. Pharmacol. Exp. Ther. 160:1968;22-31.
    • (1968) J. Pharmacol. Exp. Ther. , vol.160 , pp. 22-31
    • Lawson, J.W.1
  • 19
    • 0022549527 scopus 로고
    • Biphasic contractions induced by milrinone at low temperature in ferret ventricular muscle: Role of the sarcoplasmic reticulum and transmembrane calcium influx
    • Malecot C.O., Bers D.M., Katzung B.G. Biphasic contractions induced by milrinone at low temperature in ferret ventricular muscle: role of the sarcoplasmic reticulum and transmembrane calcium influx. Circ. Res. 59:1986;151-162.
    • (1986) Circ. Res. , vol.59 , pp. 151-162
    • Malecot, C.O.1    Bers, D.M.2    Katzung, B.G.3
  • 20
    • 0027474139 scopus 로고
    • Effects of MS-551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes
    • Nakaya H., Tohse N., Takeda Y., Kanno M. Effects of MS-551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes. Br. J. Pharmacol. 109:1993;157-163.
    • (1993) Br. J. Pharmacol. , vol.109 , pp. 157-163
    • Nakaya, H.1    Tohse, N.2    Takeda, Y.3    Kanno, M.4
  • 21
    • 0021736464 scopus 로고
    • Hemodynamic and clinical limitations of long-term inotropic therapy with amrinone in patients with severe chronic heart failure
    • Packer M., Medira N., Yushak M. Hemodynamic and clinical limitations of long-term inotropic therapy with amrinone in patients with severe chronic heart failure. Circulation. 70:1984;1038-1047.
    • (1984) Circulation , vol.70 , pp. 1038-1047
    • Packer, M.1    Medira, N.2    Yushak, M.3
  • 26
    • 0031004698 scopus 로고    scopus 로고
    • Update on digoxin and other oral positive inotropic agents for chronic heart failure
    • Reddy S., Benatar D., Gheorghiade M. Update on digoxin and other oral positive inotropic agents for chronic heart failure. Curr. Opin. Cardiol. 12:1997;233-241.
    • (1997) Curr. Opin. Cardiol. , vol.12 , pp. 233-241
    • Reddy, S.1    Benatar, D.2    Gheorghiade, M.3
  • 27
    • 0021320470 scopus 로고
    • Effect of 3,4-dihydro-6[4-(3,4-dimethoxy-benzoyl)-1-piperazyl]-2(1H)-quinolinone (OPC-8212) on the membrane currents of rabbit sino-atrial node
    • Satoh H., Hashimoto K. Effect of 3,4-dihydro-6[4-(3,4-dimethoxy-benzoyl)-1-piperazyl]-2(1H)-quinolinone (OPC-8212) on the membrane currents of rabbit sino-atrial node. Arzneim.-Forsch. 34:1984;376-380.
    • (1984) Arzneim.-Forsch. , vol.34 , pp. 376-380
    • Satoh, H.1    Hashimoto, K.2
  • 28
    • 0033136915 scopus 로고    scopus 로고
    • Pharmacological characterization of effects of UK-1745, a novel cardiotonic agent with β-adrenoceptor-blocking action, in aequorin-loaded canine right ventricular muscle
    • Sawada H., Endoh M. Pharmacological characterization of effects of UK-1745, a novel cardiotonic agent with β-adrenoceptor-blocking action, in aequorin-loaded canine right ventricular muscle. J. Mol. Cell. Cardiol. 31:1999;1047-1052.
    • (1999) J. Mol. Cell. Cardiol. , vol.31 , pp. 1047-1052
    • Sawada, H.1    Endoh, M.2
  • 30
    • 0022618614 scopus 로고
    • Effects of amrinone and milrinone on calcium influx into the myocardium
    • Sutko J.L., Kenyon J.L., Reeves J.P. Effects of amrinone and milrinone on calcium influx into the myocardium. Circulation. 73:1986;11152-11158.
    • (1986) Circulation , vol.73 , pp. 11152-11158
    • Sutko, J.L.1    Kenyon, J.L.2    Reeves, J.P.3
  • 31
    • 0020015867 scopus 로고
    • Phosphorylation of the sarcoplasmic reticulum and sarcolemma
    • Tada M., Katz A.M. Phosphorylation of the sarcoplasmic reticulum and sarcolemma. Annu. Rev. Physiol. 44:1982;401-423.
    • (1982) Annu. Rev. Physiol. , vol.44 , pp. 401-423
    • Tada, M.1    Katz, A.M.2
  • 33
    • 0023266532 scopus 로고
    • Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
    • Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N. Engl. J. Med. 316:1987;1429-1435.
    • (1987) N. Engl. J. Med. , vol.316 , pp. 1429-1435
  • 34
    • 0026457243 scopus 로고
    • + current of guinea pig ventricular cells through the activation of protein kinase C
    • + current of guinea pig ventricular cells through the activation of protein kinase C. Circ. Res. 71:1992;1441-1446.
    • (1992) Circ. Res. , vol.71 , pp. 1441-1446
    • Tohse, N.1    Nakaya, H.2    Kanno, M.3
  • 35
    • 0019038173 scopus 로고
    • Neutral carrier ion-sensitive microelectrode for measurement of intracellular calcium
    • Tsien R.Y., Rink T.J. Neutral carrier ion-sensitive microelectrode for measurement of intracellular calcium. Biochem. Biophys. Acta. 599:1980;623-638.
    • (1980) Biochem. Biophys. Acta , vol.599 , pp. 623-638
    • Tsien, R.Y.1    Rink, T.J.2
  • 36
    • 15444348051 scopus 로고    scopus 로고
    • Cardiovascular effects of (2RS,3SR)-2-aminomethyl-2,3,7,8-tetrahydro-2,3,5,8,8-pentamethyl-6H-furo-[2,3-e] indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties
    • Uchida Y., Kawada M., Sawanobori K., Sonoki H., Inoue K., Mizuno K., Itou T., Takunoki Y., Tsukamoto M., Ohashi Y., Kyoutani Y., Shimizu N., Fujii M., Nakamura M. Cardiovascular effects of (2RS,3SR)-2-aminomethyl-2,3,7,8-tetrahydro-2,3,5,8,8-pentamethyl-6H-furo-[2,3-e] indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties. Arzneim.-Forsch. 48:1998;219-231.
    • (1998) Arzneim.-Forsch. , vol.48 , pp. 219-231
    • Uchida, Y.1    Kawada, M.2    Sawanobori, K.3    Sonoki, H.4    Inoue, K.5    Mizuno, K.6    Itou, T.7    Takunoki, Y.8    Tsukamoto, M.9    Ohashi, Y.10    Kyoutani, Y.11    Shimizu, N.12    Fujii, M.13    Nakamura, M.14
  • 37
    • 0344174644 scopus 로고    scopus 로고
    • Effect of UK-1745, a novel furoindole derivative with both cardiotonic and antiarrhythmic actions, on chronic congestive heart failure in dogs
    • 227 pp.
    • Uchida Y., Sonoki H. Effect of UK-1745, a novel furoindole derivative with both cardiotonic and antiarrhythmic actions, on chronic congestive heart failure in dogs. Jpn. J. Pharmacol. 71(Suppl. I):1996;. 227 pp.
    • (1996) Jpn. J. Pharmacol. , vol.71 , Issue.SUPPL. I
    • Uchida, Y.1    Sonoki, H.2
  • 38
    • 0025071304 scopus 로고
    • Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo
    • Uretsky B.F., Jessup M., Konstam M.A., William G., Leier C.V., Benotti J., Murali S., Herrmann H.C., Sandberg J.A. Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo. Circulation. 82:1990;774-780.
    • (1990) Circulation , vol.82 , pp. 774-780
    • Uretsky, B.F.1    Jessup, M.2    Konstam, M.A.3    William, G.4    Leier, C.V.5    Benotti, J.6    Murali, S.7    Herrmann, H.C.8    Sandberg, J.A.9
  • 39
    • 0030996661 scopus 로고    scopus 로고
    • Current and newer approaches in the drug treatment of congestive heart failure
    • van Zwieten P.A. Current and newer approaches in the drug treatment of congestive heart failure. Cardiovasc. Drugs Ther. 10:1996;693-702.
    • (1996) Cardiovasc. Drugs Ther. , vol.10 , pp. 693-702
    • Van Zwieten, P.A.1
  • 40
    • 0029609858 scopus 로고
    • Classification of positive inotropic actions based on electrophysiologic characteristics: Where should calcium sensitizer be placed?
    • Varró A., Papp J.G. Classification of positive inotropic actions based on electrophysiologic characteristics: where should calcium sensitizer be placed? J. Cardiovasc. Pharmacol. 26(Suppl 1):1995;S32-S44.
    • (1995) J. Cardiovasc. Pharmacol. , vol.26 , Issue.SUPPL. 1
    • Varró, A.1    Papp, J.G.2
  • 41
    • 0027135308 scopus 로고
    • Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy for the Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group
    • Waagstein F., Bristow M.R., Swedberg K., Camerini F., Fowler M.B., Silver M.A. Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy for the Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group. Lancet. 342:1993;1441-1446.
    • (1993) Lancet , vol.342 , pp. 1441-1446
    • Waagstein, F.1    Bristow, M.R.2    Swedberg, K.3    Camerini, F.4    Fowler, M.B.5    Silver, M.A.6
  • 42
    • 0027446995 scopus 로고
    • Modulation by histamine of the delayed outward potassium current in guinea-pig ventricular myocytes
    • Yazawa K., Abiko Y. Modulation by histamine of the delayed outward potassium current in guinea-pig ventricular myocytes. Br. J. Pharmacol. 109:1993;142-147.
    • (1993) Br. J. Pharmacol. , vol.109 , pp. 142-147
    • Yazawa, K.1    Abiko, Y.2
  • 43
    • 0025012718 scopus 로고
    • Mechanism of receptor-mediated modulation on the delayed outward potassium current in guinea-pig ventricular myocytes
    • Yazawa K., Kameyama M. Mechanism of receptor-mediated modulation on the delayed outward potassium current in guinea-pig ventricular myocytes. J. Physiol. (London). 421:1990;135-150.
    • (1990) J. Physiol. (London) , vol.421 , pp. 135-150
    • Yazawa, K.1    Kameyama, M.2


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