The nuclear receptor corepressor (N-CoR) modulates basal and activated transcription of genes controlled by retinoic acid

Journal of Steroid Biochemistry and Molecular Biology

Volumn 84, Issue 1, 2003, Pages 15-21

  Loinder, Kristina ^a   Söderström, Mats ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Coactivator; Corepressor; Differentiation; Nuclear receptor; Transcriptional regulation

Indexed keywords

DIMER; LIGAND; MESSENGER RNA; NUCLEAR RECEPTOR COREPRESSOR; PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DOWN REGULATION; GENE CONTROL; GENE REPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; NONHUMAN; NORTHERN BLOTTING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

EID: 0037228759     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(03)00007-4     Document Type: Article

References (20)

1. Chambon P. The molecular and genetic dissection of the retinoid signaling pathway. Recent Prog. Horm. Res. 50:1995;317-332.
2. Evans R.M. The steroid and thyroid hormone receptor superfamily. Science. 240:1988;889-895.
3. Umesono K., Evans R.M. Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell. 57:1989;1139-1146.
4. Näär A.M., Boutin J.M., Lipkin S.M., Yu V.C., Holloway J.M., Glass C.K., Rosenfeld M.G. The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell. 65:1991;1267-1279.
5. Zhang X.K., Hoffmann B., Tran P.B., Graupner G., Pfahl M. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature. 355:1992;441-446.
6. Kliewer S.A., Umesono K., Mangelsdorf D.J., Evans R.M. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature. 355:1992;446-449.
7. Kurokawa R., Söderström M., Hörlein A., Halachmi S., Brown M., Rosenfeld M.G., Glass C.K. Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature. 377:1995;451-454.
8. Hörlein A.J., Näär A.M., Heinzel T., Torchia J., Gloss B., Kurokawa R., Ryan A., Kamei Y., Söderström M., Glass C.K., Rosenfeld M.G. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature. 377:1995;397-404.
9. Heinzel T., Lavinsky R.M., Mullen T.M., Söderström M., Laherty C.D., Torchia J., Yang W.M., Brard G., Ngo S.D., Davie J.R., Seto E., Eisenman R.N., Rose D.W., Glass C.K., Rosenfeld M.G. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature. 387:1997;43-48.
10. Nagy L., Kao H.Y., Chakravarti D., Lin R.J., Hassig C.A., Ayer D.E., Schreiber S.L., Evans R.M. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell. 89:1997;373-380.
11. Kurokawa R., DiRenzo J., Boehm M., Sugarman J., Gloss B., Rosenfeld M.G., Heyman R.A., Glass C.K. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature. 371:1994;528-531.
12. Söderström M., Vo A., Heinzel T., Lavinsky R.M., Yang W.M., Seto E., Peterson D.A., Rosenfeld M.G., Glass C.K. Differential effects of nuclear receptor corepressor (N-CoR) expression levels on retinoic acid receptor-mediated repression support the existence of dynamically regulated corepressor complexes. Mol. Endocrinol. 11:1997;682-692.
13. Halachmi S., Marden E., Martin G., MacKay H., Abbondanza C., Brown M. Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. Science. 264:1994;1455-1458.
14. J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular cloning, in: C. Nolan (Ed.), Molecular Cloning, vol. 1, Cold Spring Harbor Laboratory Press, New York, 1989.
15. Zhang J., Guenther M.G., Carthew R.W., Lazar M.A. Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes Dev. 12:1998;1775-1780.
16. Hong S.H., Wong C.W., Privalsky M.L. Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor. Mol. Endocrinol. 12:1998;1161-1171.
17. Nagy L., Kao H.Y., Love J.D., Li C., Banayo E., Gooch J.T., Krishna V., Chatterjee K., Evans R.M., Schwabe J.W. Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev. 13:1999;3209-3216.
18. Heery D.M., Kalkhoven E., Hoare S., Parker M.G. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature. 387:1997;733-736.
19. Hu X., Lazar M.A. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature. 402:1999;93-96.
20. Perissi V., Staszewski L.M., McInerney E.M., Kurokawa R., Krones A., Rose D.W., Lambert M.H., Milburn M.V., Glass C.K., Rosenfeld M.G. Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev. 13:1999;3198-3208.