On a semiparametric test to detect associations between quantitative traits and candidate genes using unrelated individuals

Genetic Epidemiology

Volumn 24, Issue 1, 2003, Pages 44-56

  Zhang, Shuanglin ^a   Zhu, Xiaofeng ^b   Zhao, Hongyu ^b  

^a HEILONGJIANG UNIVERSITY   (China)

^b NONE

Author keywords

Coalescent model; Partial linear model; Population genetics; Population stratification; Quantitative traits; Semi parametric model; Smoothing method

Indexed keywords

ARTICLE; FAMILY; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC MODEL; GENOME; GENOTYPE; HUMAN; POPULATION GENETICS; QUANTITATIVE TRAIT; SIMULATION;

ANALYSIS OF VARIANCE; BIAS (EPIDEMIOLOGY); FACTOR ANALYSIS, STATISTICAL; GENETIC MARKERS; GENETICS, POPULATION; GENOTYPE; HUMANS; LEAST-SQUARES ANALYSIS; LINEAR MODELS; MODELS, GENETIC; PEDIGREE; QUANTITATIVE TRAIT, HERITABLE; REGRESSION ANALYSIS; STATISTICS, NONPARAMETRIC; VARIATION (GENETICS);

EID: 0037228081     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.10196     Document Type: Article

References (28)

1. Abecasis GR, Cardon LR, Cookson OC. 2000. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-92.
2. Bacanu SA, Devlin B, Roeder K. 2000. The power of genomic control. Am J Hum Genet 66:1933-44.
3. Bacanu SA, Devlin B, Roeder K. 2002. Association studies for quantitative traits in structured populations. Genet Epidemiol 22:78-93.
4. Cheung KH, Osier MV, Kidd JR, Pakstis AJ, Miller PL, Kidd KK. 2000. ALFRED: an allele frequency database for diverse populations and DNA polymorphisms. Nucleic Acids Res 29:361-3.
5. Devlin B, Roeder K. 1999. Genomic control for association studies. Biometrics 55:997-1004.
6. Devlin B, Roeder K, Wasserman L. 2001. Genomic control, a new approach to genetic-based association studies. Theor Popul Biol 60:155-66.
7. Engle R, Granger C, Rice J, Weiss A. 1986. Nonparametric estimates of the relation between weather and electricity sales. J Am Stat Assoc 81:310-320.
8. Fulker DW, Cherny SS, Sham PC, Hewitt JK. 1999. Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 64:259-67.
9. Green P, Jennison C, Seheult A. 1985. Analysis of field experiments by least squares smoothing. J R Stat Soc B 47:299-315.
10. Hamilton SA, Truong YK. 1997. Local linear estimation in partly linear model. J Multi Anal 60:1-19.
11. Hart JD. 1997. Nonparametric smoothing and lack-of-fit tests. New York: Springer.
12. Monks SA, Kaplan NL. 2000. Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus. Am J Hum Genet 66:576-92.
13. Nguyan HT, Rogers GS. 1989. Fundamentals of mathematical statistics: volume II: statistical inference. New York: Springer-Verlag.
14. Pritchard JK, Donnelly P. 2001. Case-control studies of association in structured or admixtured populations. Theor Popul Biol 60:227-37.
15. Pritchard JK, Stephens M, Donnelly P. 2000a. Inference of population structure using multilocus genotype data. Genetics 155:945-59.
16. Pritchard JK, Stephens M, Rosenberg NA, Donnelly P. 2000b. Association mapping in structured population Am J Hum Genet 67:170-81.
17. Reich DE, Goldstein DB. 2001. Detecting association in a case-control study while correcting for population stratification. Genet Epidemiol 20:4-16.
18. Rosenbaum PR, Rubin DB. 1984. Reducing bias in observational studies using subclassification on the propensity score. J Am Stat Assoc 79:516-24.
19. Satten GA, Flanders WD, Yang Q. 2001. Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model. Am J Hum Genet 68:466-77.
20. Sham PC, Cherny SS, Purcell S, Hewitt JK. 2000. Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. Am J Hum Genet 66:1616-30.
21. Shiau J, Wahba G, Johnson DR. 1986. Partial spline models for the inclusion of tropopause and frontal boundary information in otherwise smooth two and three dimensional objective analysis. J Atmos Ocean Technol 3:714-25.
22. Simonoff JS. 1996. Smoothing methods in statistics. New York: Springer.
23. Speckman P. 1988. Kernel smoothing in partial linear models. J R Stat Soc B 50:413-36.
24. Sun F, Flanders WD, Yang Q, Zhao HY. 2000. Transmission/disequilibrium tests for quantitative traits. Ann Hum Genet 64:555-65.
25. Wahba G. 1984. Partial spline models for semiparametric estimation of functions of several variables. In analyses for Time Series, Japan-Us Joint Sem, 319-29. Tokyo: Institute of Statistical Mathematics.
26. Zhang SL, Zhao HY. 2001. Quantitative similarity-based association tests using population samples. Am J Hum Genet 69:601-14.
27. Zhang SL, Kidd KK, Zhao HY. 2002. Detecting genetic association in case-control studies using similarity-based association tests. Stat Sin 12:337-59.
28. Zhu X, Zhang SL, Zhao HY, Cooper RS. 2002. Association mapping using a mixture model for complex traits. Genetic Epidemiol 23:181-196.