Characterization of the portal signal in a nonsteady hyperglycemic state in conscious dogs

American Journal of Physiology - Endocrinology and Metabolism

Volumn 284, Issue 1 47-1, 2003, Pages

  Ogihara, N ^a   Ebihara, S ^a   Kawamura, W ^a   Okamoto, M ^a   Sakai, T ^a   Takiguchi, K ^a   Morita, T ^a   Uchida, R ^a   Matsuyama, Y ^b   Hayashi, Y ^c   Arakawa, Y ^c   Kikuchi, M ^a  

^a INSTITUTE FOR ADULT DISEASES   (Japan)

^b KYOTO UNIVERSITY SCHOOL OF PUBLIC HEALTH   (Japan)

^c NIHON UNIVERSITY   (Japan)

Author keywords

Glucose delivery route; Hepatic glucose load; Hepatic glucose uptake; Insulin dependency

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; LIVER METABOLISM; MALE; NONHUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0037225580     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00079.2002     Document Type: Article

References (17)

1. Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, and Cherrington AD. Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest 79: 557-565, 1987.
2. Adkins-Marshall BA, Myers SR, Hendrick GK, Williams PE, Triebwasser K, Floyd B, and Cherrington AD. Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dog. Diabetes 39: 87-95, 1990.
3. Alzaid AA, Dinneen SF, Turk DJ, Caumo A, Cobelli C, and Rizza RA. Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans. J Clin Invest 94: 2341-2348, 1994.
4. Bruttomesso D, Pianta A, Mari A, Valerio A, Marescotti M-C, Avogaro A, Tiengo A, and Del Prato S. Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. Diabetes 48: 99-105, 1999.
5. Burcelin R, Dolci W, and Thorens B. Portal glucose infusion in the mouse induces hypoglycemia. Evidence that the hepatoportal glucose sensor stimulates glucose utilization. Diabetes 49: 1635-1642, 2000.
6. DeFronzo RA, Ferrannini E, Hendler R, Wahren J, and Felig P. Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci USA 75: 5173-5177, 1978.
7. Doeden B and Rizza R. Use of variable insulin infusion to assess insulin action in obesity: Defects in both the kinetics and amplitude of response. J Clin Endocrinol Metab 64: 902-908, 1987.
8. Galassetti P, Shiota M, Zinker BA, Wasserman DH, and Cherrington AD. A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake. Am J Physiol Endocrinol Metab 275: E101-E111, 1998.
9. Horikawa S, Ishida T, Igawa K, Kawanishi K, Hartley CJ, and Takahara J. Both positive and negative portal venous and hepatic arterial glucose gradients stimulate hepatic glucose uptake after the same amount of glucose is infused into the splanchnic bed in conscious dogs. Metabolism 47: 1295-1302, 1998.
10. Kikuchi M. Modulation of insulin secretion in non-insulindependent diabetes mellitus by two novel oral hypoglycemic agents, NN623 and A4166. Diabet Med 13: S151-S155, 1996.
11. Mathews DR, Naylor BA, Jones RG, Ward GM, and Turner RC. Pulsatile insulin has greater hypoglycemic effect than continuous delivery. Diabetes 32: 617-621, 1983.
12. Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, and Shulman GI. Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin Invest 88: 578-587, 1991.
13. Moore MC, Hsien P-S, Neal DW, and Cherrington AD. Nonhepatic response to portal glucose delivery in conscious dogs. Am J Physiol Endocrinol Metab 279: E1271-E1277, 2000.
14. Myers SR, Biggers DW, Neal DW, and Cherrington AD. Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J Clin Invest 88: 158-167, 1991.
15. Myers SR, McGuinness OP, Neal DW, and Cherrington AD. Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest 87: 930-939, 1991.
16. Pagliassotti MJ, Myers SR, Moore MC, Neal DW, and Cherrington AD. Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs. Diabetes 40: 1659-1668, 1991.
17. Paolisso G, Scheen AJ, Giugliano D, Sgambato S, Albert A, Varricchio M, D'Onofrio F, and Lefebvre PJ. Pulsatile insulin delivery has greater metabolic effects than continuous hormone administration in man: Importance of pulse frequency. J Clin Endocrinol Metab 72: 607-615, 1991.