Identification and quantification of in vitro adduct formation between protein reactive xenobiotics and a lysine-containing model peptide

Environmental Toxicology

Volumn 18, Issue 1, 2003, Pages 29-36

  Reichardt, Peter ^a   Schreiber, André ^a   Wichmann, Gunnar ^b   Metzner, Gerhard ^a   Efer, Juergen ^a   Raabe, Ferdinand ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

Author keywords

Adducts; Immunotoxic effects; Lysine; Mass spectrometry; Peptides; Proteins; Xenobiotics

Indexed keywords

ALDEHYDES; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MOLECULAR STRUCTURE; PROTEINS;

XENOBIOTICS;

TOXIC MATERIALS;

1 FLUORO 2,4 DINITROBENZENE; ACETALDEHYDE; ALDEHYDE DERIVATIVE; BENZALDEHYDE; DANSYL CHLORIDE; FORMALDEHYDE; LYSINE; PHTHALIC ANHYDRIDE; SCHIFF BASE; TOLUENE DIISOCYANATE; TRINITROBENZENESULFONIC ACID; TYROSINE; XENOBIOTIC AGENT;

PEPTIDE;

ARTICLE; CHEMICAL BINDING; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; COVALENT BOND; DNA ADDUCT; FLOW INJECTION ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MACROMOLECULE; MASS SPECTROMETRY; MOLECULAR MECHANICS; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; T LYMPHOCYTE;

ALDEHYDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LYSINE; MASS SPECTROMETRY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; TYROSINE; XENOBIOTICS;

EID: 0037224368     PISSN: 15204081     EISSN: None     Source Type: Journal    
DOI: 10.1002/tox.10097     Document Type: Article

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