Differential cytokine pattern in the spleens and livers of BALB/c mice infected with Penicillium marneffei: Protective role of gamma interferon

Infection and Immunity

Volumn 71, Issue 1, 2003, Pages 465-473

  Sisto, Francesca ^a   Miluzio, Annarita ^a   Leopardi, Orazio ^b   Mirra, Maurizio ^b   Boelaert, Johan R ^c   Taramelli, Donatella ^a,d  

^a UNIVERSITY OF MILAN   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

^c General Hospital St Jan   (Belgium)

^d Istituto di Endocrinologia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONIDIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FUNGICIDAL ACTIVITY; HISTOPATHOLOGY; IMMUNE RESPONSE; LIVER GRANULOMA; MACROPHAGE; MOUSE; MYCOSIS; NONHUMAN; PENICILLIUM MARNEFFEI; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; CELL LINE; CYTOKINES; FEMALE; GRANULOMA; INTERFERON TYPE II; LIVER; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MYCOSES; PENICILLIUM; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN;

EID: 0037218473     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.1.465-473.2003     Document Type: Article

References (35)

1. Allendoerfer, R., and G. Deepe, Jr. 1997. Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice. Infect. Immun. 65:2564-2569.
2. Cenci, E., A. Mencacci, R. Spaccapelo, L. Tonnetti, P. Mosci, K. Enssle, P. Puccetti, L. Romani, and F. Bistoni. 1995. T helper cell type 1 (Th1)- and Th2-like responses are present in mice with gastric candidiasis but protective immunity is associated with Th1 development. J. Infect. Dis. 171:1279-1288.
3. Cenci, E., A. Mencacci, G. Del Sero, C. Fe'd'Ostiani, P. Mosci, A. Bacci, C. Montagnoli, M. Kopf, and L. Romani. 1998. IFN-γ is required for IL-12 responsiveness in mice with Candida albicans infection. J. Immunol. 161: 3543-3550.
4. Cenci, E., S. Perito, K. Enssle, P. Mosci, J. P. Latgé, L. Romani, and F. Bistoni. 1997. Th1 and Th2 cytokines in mice with invasive aspergillosis. Infect. Immun. 65:564-570.
5. Clerici, M., E. Seminari, F. Suter, F. Castelli, A. Pan, M. Biasin, F. Colombo, D. Trabattoni, F. Maggiolo, G. Carosi, R. Maserati, and the Master Group. 2000. Different immunologic profiles characterize HIV infection in highly active antiretroviral therapy-treated and antiretroviral-naive patients with undetectable viraemia. AIDS 14:109-116.
6. Cogliati, M., A. Roverselli, J. R. Boelaert, D. Taramelli, L. Lombardi, and A. M. Viviani. 1997. Development of an in vitro macrophage system to assess Penicillium marneffei growth and susceptibility to nitric oxide. Infect. Immun. 65:279-284
7. Cooper, A., D. Dalton, T. Stewart, J. Griffin, D. Russel, and L. Orme. 1993. Disseminated tuberculosis in interferon-γ gene-disrupted mice. J. Exp. Med. 178:2243-2247.
8. Cooper, C. R. 1998. From bamboo rats to humans: Odyssey of Penicillium marneffei. ASM News 64:390-397
9. Cui, J., R. Tanaka, H. Taguchi, A. Sano, E. Ito, K. Fukushima, K. Takeo, S. Yoshida, K. Nishimura, and M. Miyaji. 1997. Histopathological and electron microscopical studies on experimental Penicillium marneffei infection in mice. J. Med. Vet. Mycol. 35:347-353.
10. Cunha, F. Q., J. Assreuy, D. W. Moss, D. Rees, L. M. Leal, S. Moncada, M. Carrier, C. A. O'Donnell, and F. Y. Liew. 1994. Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: Role of TNF-alpha and IL-1-beta. Immunology 81:211-215.
11. Dalton, D., S. Pitts-Meek, S. Keshav, I. Figari, A. Bradley, and T. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739-1742.
12. Deepe, G., Jr., L. Romani, V. Calich, G. Huffnagles, C. Arruda, E. Molinari-Madlum, and J. Perfect. 2000. Knockout mice as experimental models of virulence. Med. Mycol. 38(Suppl. 1):87-98.
13. Duong, T. A. 1996. Infection due to Penicillium marneffei, an emerging pathogen: Review of 155 reported cases. Clin. Infect. Dis. 23:125-130.
14. Erb, K., J. Kirman, B. Delahunt, and G. LeGros. 1999. Infection of mice with Mycobacterium bovis BCG induces both Th1 and Th2 immune responses in the absence of interferon-γ signalling. Eur. Cytokine Netw. 10:147.
15. Fenhalls, G., A. Wong, J. Bezuidenhout, P. van Helden, P. Bardin, and P. T. Lukey. 2000. In situ production of gamma interferon, interleukin-4, and tumor necrosis factor alpha mRNA in human lung tuberculous granulomas. Infect. Immun. 68:2827-2836.
16. Gudmundsson, G., and G. W. Huninghake. 1997. Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis. J. Clin. Investig. 99:2386-2390.
17. Huffnagle, G. B., and M. F. Lipscomb. 1998. Cells and cytokines in pulmonary cryptococcosis. Res. Immunol. 149:387-396.
18. Jouanguy, E., R. Doffinger, S. Dupuis, A. Pallier, F. Altare, and J. Casanova. 1999. IL-12 and IFN-γ in host defense against mycobacteria and salmonella in mice and men. Curr. Opin. Immunol. 11:346-351.
19. Kamijo, R., J. Le, D. Shapiro, E. Havell, S. Huang, M. Aguet, M. Bosland, and J. Vilcek. 1993. Mice that lack the interferon-γ receptor have profoundly altered responses to infection with bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide. J. Exp. Med. 178:1435-1440.
20. Kaposzta, R., P. Tree, L. Marodi, and S. Gordon. 1998. Characteristics of invasive candidiasis in gamma interferon- and interleukin-4-deficient mice: Role of macrophages in host defense against Candida albicans. Infect. Immun. 66:1708-1717.
21. Kudeken, N., K. Kawakami, and A. Saito. 1997. CD4+ T cell-mediated fatal hyperinflammatory reactions in mice infected with Penicillium marneffei. Clin. Exp. Immunol. 107:468-473.
22. Kudeken, N., K. Kawakami, N. Kusano, and A. Saito. 1996. Cell-mediated immunity in host resistance against infection caused by Penicillium marneffei. J. Med. Vet. Mycol. 34:371-378.
23. Kudeken, N., K. Kawakami, and A. Saito. 1998. Different susceptibilities of yeasts and conidia of Penicillium marneffei to nitric oxide (NO)-mediated fungicidal activity of murine macrophages. Clin. Exp. Immunol. 112:287-293.
24. Marzo, A. L., V. Vezys, K. Williams, D. F. Tough, and L. Lefrancois. 2002. Tissue-level regulation of Th1 and Th2 primary, and memory CD4 T cells in response to Listeria infection. J. Immunol. 168:4504-4510.
25. Nagai, H., J. Guo, H. Choi, and V. Kurup. 1995. Interferon-gamma and tumor necrosis factor-alpha protect mice from invasive aspergillosis. J. Infect. Dis. 172:1554-1560.
26. Pearl, J., B. Saunders, S. Ehlers, I. Orme, and A. Cooper. 2001. Inflammation and lymphocyte activation during mycobacterial infection in the interferon-γ-deficient mouse. Cell. Immunol. 211:43-50.
27. Romagnani, S. 1997. The Th1/Th2 paradigm. Immunol. Today 18:263-266.
28. Romani, L. 1999. Immunity to Candida albicans: Th1, Th2 cells and beyond. Curr. Opin. Microbiol. 2:363-367.
29. Supparatpinyo, K., C. Khamwan, V. Baosoung, K. Nelson, and T. Sirisanthana. 1994. Disseminated Penicillium marneffei infection in Southeast Asia. Lancet 344:110-113.
30. Taramelli, D., S. Brambilla, G. Sala, A. Bruccoleri, C. Tognazioli, L. L. Riviera-Uzielli, and J. R. Boelaert. 2000. Effect of iron on the extracellular and intracellular growth of Penicillium marneffei. Infect. Immun. 68:1724-1726.
31. Taramelli, D., M. Malabarba, G. Sala, N. Basilico, and G. Cocuzza. 1996. Production of cytokines by alveolar and peritoneal macrophages stimulated by Aspergillus fumigatus conidia or hyphae. J. Med. Vet. Mycol. 34:49-56.
32. Viviani, M. A., J. O. Hill, and D. M. Dixon. 1993. Penicillium marneffei: Dimorphism and treatment, p. 413-422. In H. van den Bossche, F. Odds, and D. Kerridge (ed.), Dimorphic Fungi in Biology and Medicine. Plenum Press, New York, N.Y.
33. Viviani, M. A., A. M. Tortorano, G. Rizzardini, T. Quirino, L. Kaufman, A. A. Padhye, and L. Ajello. 1993. Treatment and serological studies of an Italian case of penicillinosis marneffei contracted in Thailand by a drug addict infected with the human immunodeficiency virus. Eur. J. Epidemiol. 9:79-85.
34. Wynn, A., I. Eltoum, A. Cheever, F. Lewis, W. Gause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1430-1440.
35. Zhou, P., G. Miller, and R. Seder. 1998. Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-α plays a critical role in maintaining secondary immunity in the absence of interferon-γ. J. Immunol. 160:1359-1368.