Common expression of an unusual CD45 isoform on T cells from patients with large granular lymphocyte leukaemia and autoimmune lymphoproliferative syndrome

British Journal of Haematology

Volumn 120, Issue 1, 2003, Pages 93-96

  Bleesing, Jack J H ^a,b   Janik, John E ^a   Fleisher, Thomas A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ARKANSAS CHILDREN S HOSPITAL RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; Autoimmune lymphoproliferative syndrome; CD45 isoforms; Glycosylation; T LGL leukaemia

Indexed keywords

CD45 ANTIGEN; ISOPROTEIN; PHOSPHATASE; TYROSINE;

APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; HUMAN; HUMAN CELL; LARGE GRANULAR LYMPHOCYTE; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; LYMPHOPROLIFERATIVE DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; T CELL LEUKEMIA; T LYMPHOCYTE;

ANTIGENS, CD45; APOPTOSIS; AUTOIMMUNE DISEASES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; FLOW CYTOMETRY; GLYCOSYLATION; HUMANS; LEUKEMIA, T-CELL; LYMPHOPROLIFERATIVE DISORDERS; PROTEIN ISOFORMS; T-LYMPHOCYTES;

EID: 0037217579     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04034.x     Document Type: Article

References (12)

1. Bleesing, J.J.H. (2002) Autoimmune lymphoproliferative syndrome: A human disorder of abnormal lymphocyte survival. Immunology and Allergy Clinics of North America, 22, 339-355.
2. - T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clinical Immunology, 100, 314-324.
3. Bleesing, J.J.H., Morrow, M.R., Uzel, G. & Fleisher, T.A. (2001b) Human T cell activation induces the expression of a novel CD45 isoform that is analogous to murine B220 and is associated with altered O-glycan synthesis and onset of apoptosis. Cellular Immunology, 213, 72-81.
4. Epling-Burnette, P.K., Liu, J.H., Catlett-Falcone, R., Turkson, J., Oshiro, M., Kotapalli, R., Li, Y., Wang, J.M., Yang-Yen, H.F., Karras, J., Jove, R. & Loughran, Jr, T.P. (2001) Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. Journal of Clinical Investigation, 107, 351-362.
5. Galvan, M., Tsuboi, S., Fukuda, M. & Baum, L.G. (2000) Expression of a specific glycosyltransferase enzyme regulates T cell death mediated by galectin-1. Journal of Biological Chemistry, 275, 16730-16737.
6. Harrington, L.E., Galvan, M., Baum, L.G., Altman, J.D. & Ahmed, R. (2000) Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. Journal of Experimental Medicine, 191, 1241-1246.
7. Irie-Sasaki, J., Sasaki, T., Matsumoto, W., Opavsky, A., Cheng, M., Welstead, G., Griffiths, E., Krawczyk, C., Richardson, C.D., Aitken, K., Iscove, N., Koretzky, G., Johnson, P., Liu, P., Rothstein, D.M. & Penninger, J.M. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature, 409, 349-354.
8. Lamy, T. & Loughran, Jr, T.P. (1999) Current concepts: Large granular lymphocyte leukemia. Blood Reviews, 13, 230-240.
9. + T cells in large granular lymphocyte leukemia are not defective in activation- and replication-related apoptosis. Leukemia Research, 25, 699-708.
10. + lymphocyte populations. British Journal of Haematology, 112, 189-194.
11. Piller, F., Le Deist, F., Weinberg, K.I., Parkman, R. & Fukuda, M. (1991) Altered O-glycan synthesis in lymphocytes from patients with Wiskott-Aldrich syndrome. Journal of Experimental Medicine, 173, 1501-1510.
12. Renno, T., Attinger, A., Rimoldi, D., Hahne, M., Tschopp, J. & MacDonald, H.R. (1998) Expression of B220 on activated T cell blasts precedes apoptosis. European Journal of Immunology, 28, 540-547.