Protective effects of superoxide dismutase against ischemia-reperfusion injury: Development and application of a transgenic animal model

Plastic and Reconstructive Surgery

Volumn 111, Issue 1, 2003, Pages 251-255

  Klein, Matthew B ^a,b   Chan, Pak H ^a,b   Chang, James ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; FREE RADICAL; HYDROGEN PEROXIDE; OXYGEN; SCAVENGER; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; GENE DELETION; GENE OVEREXPRESSION; ISCHEMIA; ISLAND FLAP; KNOCKOUT MOUSE; MOLECULAR CLONING; MOUSE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; REPERFUSION INJURY; SKIN FLAP SURVIVAL; TISSUE NECROSIS; TRANSGENIC MOUSE; WILD TYPE;

EID: 0037215579     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-200301000-00042     Document Type: Article

References (16)

1. Suzuki, S., Yoshioka, N., Isshiki, N., et al. Involvement of reactive oxygen species in post-ischemic flap necrosis and its prevention by antioxidants. Br. J. Plast. Surg. 44: 130, 1991.
2. Parks, D. A., Bulkley, G. B., Granger, D. N., et al. Ischemic injury in the cat small intestine: Role of superoxide radicals. Gastroenterology 82: 9, 1982.
3. Stewart, J. R., Blackwell, W. H., Crule, S. L., et al. Prevention of myocardial ischemia reperfusion injury with oxygen free radical scavengers. Surg. Forum 33: 317, 1982.
4. Elroy-Stein, O., Bernstein, Y., and Groner, Y. Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: Extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation. EMBO J. 5: 615, 1986.
5. Im, M. J., Manson, P. N., Bulkley, G. B., and Hoopes, J. E. Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps. Ann. Surg. 201: 357, 1985,
6. Manson, P. N., Anthenelli, R. M., Im, M. J., et al. The role of oxygen-free radicals in ischemic tissue injury in island skin flaps. Ann. Surg. 198: 87, 1983,
7. Marzella, L., Jesudass, R. R., Manson, P. N., et al. Functional and structural evaluation of the vasculature of skin flaps after ischemia and reperfusion. Plast. Reconstr. Surg. 81: 742, 1988.
8. Izquierdo, R., Swartz, W. M., Sutker, K. B., et al. Attenuation of reperfusion-induced lipoperoxidation by systemic use of oxygen radical scavengers after pedicle occlusion. Ann. Plast. Surg. 28: 175, 1992.
9. Sagi, A., Ferder, M., Levens, D., and Strauch, B. Improved survival of island flaps after prolonged ischemia by perfusion with superoxide dismutase. Plast. Reconstr. Surg. 77: 659, 1986.
10. Goossens, D. P., Rao, V. K., Harms, B. A., and Starling, J. R. Superoxide dismutase and catalase in skin flaps during venous occlusion and reperfusion. Ann. Plast. Surg. 25: 21, 1990.
11. Angel, M. F., Ramasastry, S. S., Swartz, W. M., et al. The critical relationship between free radicals and degrees of ischemia: Evidence for tissue intolerance of marginal perfusion. Plast. Reconstr. Surg. 81: 233, 1988.
12. Epstein, C. J., Avraham, K. B., Lovett, M., et al. Transgenic mice with increased Cu/Zn-superoxide dismutase activity: Animal model of dosage effects in Down syndrome. Proc. Natl. Acad. Sci. U.S.A. 84: 8044, 1987.
13. Kamii, H., Kinouchi, H., Sharp, F. R., et al. Prolonged expression of hsp 70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase. J. Cereb. Blood Flow Metab. 14: 478, 1994.
14. Fujimura, M., Morita-Fujimura, Y., Narasimhan, P., et al. Copper-zinc superoxide dismutase prevents the early decrease of apurinic/apyrimidinic endonuclease and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 30: 2408, 1999.
15. Kawase, M., Murakami, K., Fujimura, M., et al. Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency. Stroke 30: 1962, 1999.
16. Huang, T. T., Carlson, E.J., Raineri, I., et al. The use of transgenic and mutant mice to study oxygen free radical metabolism. Ann. N.Y. Acad. Sci. 893: 95, 1999.