Beclomethasone rapidly ablates allergen-induced β2-adrenoceptor pathway dysfunction in human isolated bronchi

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 284, Issue 1 28-1, 2003, Pages

  Brichetto, Lorenzo ^a   Milanese, Manlio ^a   Song, Pingfang ^a   Patrone, Mauro ^a   Crimi, Emanuele ^a   Rehder, Kai ^a   Brusasco, Vito ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Asthma; Cholera toxin; Corticosteroids; Gs protein; Passive sensitization

Indexed keywords

ADENYLATE CYCLASE; ALLERGEN; BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLERA TOXIN; CHOLINERGIC RECEPTOR BLOCKING AGENT; FORSKOLIN; SALBUTAMOL; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; THEOPHYLLINE;

ALLERGY; ARTICLE; BRONCHOSPASM; BRONCHUS; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION;

EID: 0037213995     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00217.2002     Document Type: Article

References (31)

1. Bai TR. Abnormalities in airway smooth muscle in fatal asthma. Am Rev Respir Dis 141: 552-557, 1990.
2. Barnes PJ. Mechanism of action of glucocorticoids in asthma. Am J Respir Crit Care Med 154: S21-S27, 1996.
3. Barnes PJ. β-adrenergic receptors and their regulation. Am J Respir Crit Care Med 152: 838-860, 1995.
4. Belvisi MG, Patel HJ, Takahashi T, Barnes PJ, and Giembycz MA. Paradoxical facilitation of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by isoprenaline. Br J Pharmacol 117: 1413-1420, 1996.
5. 2-bronchodilators. Eur J Clin Pharmacol 34: 145-150, 1988.
6. Ellul-Micallef R and Fenech FF. Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness. Lancet 2: 1269-1271, 1975.
7. Grandordy BM, Mak JWC, and Barnes PJ. Modulation of airway smooth muscle β-adrenoceptor function by a muscarinic agonist. Life Sci 54: 185-191, 1994.
8. Hakonarson H, Herrick DJ, and Grunstein MM. Mechanisms of impaired β-adrenoceptor responsiveness in atopic sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 269: L645-L652, 1995.
9. Hayes MJ, Qing F, Rhodes CG, Rahman SU, Ind PW, Sriskandan S, Jones T, and Hughes JMB. In vivo quantification of human pulmonary β-adrenoceptors: Effect of β-agonist therapy. Am J Respir Crit Care Med 154: 1277-1283, 1996.
10. Hirata N, Kohrogi H, Iwagoe H, Goto E, Hamamoto J, Fujii K, Yamaguchi T, Kawano O, and Ando M. Allergen exposure induces the expression of endothelial adhesion molecules in passively sensitized human bronchus: Time course and the role of cytokines. Am J Respir Cell Mol Biol 18: 12-20, 1998.
11. Hirst SJ and Lee TH. Airway smooth muscle as a target of glucocorticoid action in the treatment of asthma. Am J Respir Crit Care Med 158: S201-S206, 1998.
12. Hui KKP, Connolly ME, and Taskin DP. Reversal of human lymphocyte β-adrenoceptor desensitization by glucocorticoids. Clin Pharmacol Ther 32: 566-571, 1982.
13. sα protein expression in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 278: L1101-L1106, 2000.
14. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
15. Lee SW, Tsou AP, Chan H, Thomas J, Petrie K, Eugui EM, and Allison AC. Glucocorticoids selectively inhibit the transcription of the interleukin-1β gene and decrease the stability of interleukin-1β mRNA. Proc Natl Acad Sci USA 85: 1204-1208, 1988.
16. Lin RY, Pesola GR, Bakalchuk L, Heyl GT, Dow AM, Tenenbaum C, Curry A, and Westfal RE. Rapid improvement of peak flow in asthmatic patients treated with parenteral methylprednisolone in the emergency department: A randomized controlled study. Ann Emerg Med 33: 487-494, 1999.
17. Lipworth BJ and Aziz I. Bronchodilator response to albuterol after regular formoterol and effects of acute corticosteroid administration. Chest 117: 156-162, 2000.
18. 2-adrenergic receptor transcription in human lung. Am J Physiol Lung Cell Mol Physiol 268: L41-L46, 1995.
19. Moore PE, Laporte JD, Gonzalez S, Moller W, Heyder J, Panettieri RA Jr, and Shore SA. Glucocorticoids ablate IL-1β-induced β-adrenergic hyporesponsiveness in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 277: L932-L942, 1999.
20. Nijkamp FP, Engels F, Henricks PAJ, and Van Oosterhout AJM. Mechanism of β-adrenergic receptor regulation in lungs and its implication for physiological responses. Physiol Rev 72: 323-367, 1992.
21. Palejwala S and Goldsmith LT. Ovarian expression of cellular ki-ras p21 varies with physiological status. Proc Natl Acad Sci USA 89: 4202-4206, 1992.
22. Pitcher J, Lohse MJ, Codona J, Caron MG, and Lefkovitz RJ. The sensitization of the isolated β-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs in distinct molecular mechanisms. Biochemistry 31: 3193-3197, 1992.
23. Rodrigo G and Rodrigo C. Corticosteroids in the emergency department therapy of acute adult asthma: An evidence-based evaluation. Chest 116: 285-295, 1999.
24. + pump-mediated relaxation in maturing airway smooth muscle. Br J Pharmacol 119: 807-812, 1996.
25. Seamon KB, Padgett W, and Daly JW. Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc Natl Acad Sci USA 78: 3363-3367, 1981.
26. Shore SA, Laporte J, Hall IP, Hardy E, and Panettieri RA Jr. Effect of IL-1β on responses of cultured human airway smooth muscle cells to bronchodilator agonists. Am J Respir Cell Mol Biol 16: 702-712, 1997.
27. 2-receptor dysfunction in isolated human bronchi. Am J Respir Crit Care Med 158: 1809-1814, 1998.
28. s-protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. Am J Physiol Lung Cell Mol Physiol 279: L209-L215, 2000.
29. 2 receptor function. Am J Respir Crit Care Med 155: 1230-1234, 1997.
30. Song P, Rocchi D, Lazzarotti M, Crimi E, Rehder K, and Brusasco V. Postjunctional effect of pinacidil on contractility of isolated bovine trachealis. Eur Respir J 9: 2057-2063, 1996.
31. Tan KS, Grove A, McLean A, Gnosspelius Y, Hall IP, and Lipworth BJ. Systemic corticosteroid rapidly reverses bronchodilator subsensitivity induced by formoterol in asthmatic patients. Am J Respir Crit Care Med 156: 28-35, 1997.