G protein subunit Gγ13 is coexpressed with Gαo, Gβ3, and Gβ4 in retinal ON bipolar cells

Journal of Comparative Neurology

Volumn 455, Issue 1, 2003, Pages 1-10

  Huang, Liquan ^a,b,e   Max, Marianna ^a   Margolskee, Robert F ^a,b   Su, Hui ^c   Masland, Richard H ^c   Euler, Thomas ^c,d  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^e Gonell Chemical Senses Center   (United States)

Author keywords

Gene expression profiling; Mammalian retina; Signal transduction; Single cell RT PCR; Transgenic

Indexed keywords

GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELL SUBPOPULATION; CONTROLLED STUDY; DENDRITE; DNA PROBE; FLUORESCENCE; HYBRIDIZATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PATCH CLAMP; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA; RETINA BIPOLAR GANGLION CELL; RETINA CONE; RETINA ROD; SIGNAL TRANSDUCTION;

ANIMALS; CONES (RETINA); GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HETEROTRIMERIC GTP-BINDING PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN SUBUNITS; RETINA; RODS (RETINA);

EID: 0037211261     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.10396     Document Type: Article

References (54)

1. Awatramani GB, Slaughter MM. 2000. Origin of transient and sustained responses in ganglion cells of the retina. J Neurosci 20:7087-7095.
2. 2+ entry. Science 292:293-297.
3. Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP. 2001. G{beta} association and effector interaction selectivities of the divergent G{gamma} subunit G{gamma}13. J Biol Chem 23:23.
4. Boos R, Schneider H, Wässle H. 1993. Voltage- and transmitter-gated currents of All-amacrine cells in a slice preparation of the rat retina. J Neurosci 13:2874-2888.
5. Brady G, Iscove NN. 1993. Construction of cDNA libraries from single cells. Methods Enzymol 225:611-623.
6. Brandstätter JH, Koulen P, Wässle H. 1998. Diversity of glutamate receptors in the mammalian retina. Vision Res 38:1385-1397.
7. Dhingra A, Lyubarsky A, Jiang M, Pugh EN Jr, Birnbaumer L, Sterling P, Vardi N. 2000. The light response of ON bipolar neurons requires G{alpha}o. J Neurosci 20:9053-9058.
8. Dolphin AC. 1998. Mechanisms of modulation of voltage-dependent calcium channels by G proteins. J Physiol 506:3-11.
9. Dulac C, Axel R. 1995. A novel family of genes encoding putative pheromone receptors in mammals. Cell 83:195-206.
10. Euler T, Masland RH. 2000. Light-evoked responses of bipolar cells in a mammalian retina. J Neurophysiol 83:1817-1829.
11. Euler T, Wässle H. 1995. Immunocytochemical identification of cone bipolar cells in the rat retina. J Comp Neurol 361:461-478.
12. Famiglietti EVJ. 1983. ON and OFF pathways through amacrine cells in mammalian retina: The synaptic connections of "starburst" amacrine cells. Vision Res 23:1265-1279.
13. Famiglietti EV, Kolb H. 1976. Structural basis for ON- and OFF-center responses in retinal ganglion cells. Science 194:193-195.
14. Feigenspan A, Bormann J. 1994. Differential pharmacology of GABA(A) and GABA(C) receptors on rat retinal bipolar cells. Eur J Pharmacol 288:97-104.
15. Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR. 2000. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28:41-51.
16. Ferreira PA, Pak WL. 1994. Bovine phospholipase C highly homologous to the norpA protein of Drosophila is expressed specifically in cones. J Biol Chem 269:3129-3131.
17. Gilbertson TA, Damak S, Margolskee RF. 2000. The molecular physiology of taste transduction. Curr Opin Neurobiol 10:519-527.
18. Greferath U, Grünert U, Wässle H. 1990. Rod bipolar cells in the mammalian retina show protein kinase C-like immunoreactivity. J Comp Neurol 301:433-442.
19. Gustincich S, Feigenspan A, Wu DK, Koopman LJ, Raviola E. 1997. Control of dopamine release in the retina: A transgenic approach to neural networks. Neuron 18:723-736.
20. Hamm HE. 1998. The many faces of G protein signaling. J Biol Chem 273:669-672.
21. Hepler JR, Gilman AG. 1992. G proteins. Trends Biochem Sci 17:383-387.
22. Hille B. 1994. Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci 17:531-536.
23. Hirano AA, MacLeish PR. 1991. Glutamate and 2-amino-4-phosphonobutyrate evoke an increase in potassium conductance in retinal bipolar cells. Proc R Soc Lond B 88:805-809.
24. Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF. 1999. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci 2:1055-1062.
25. Jiang H, Lyubarsky A, Dodd R, Vardi N, Pugh E, Baylor D, Simon MI, Wu D. 1996. Phospholipase C beta 4 is involved in modulating the visual response in mice. Proc Natl Acad Sci U S A 93:14598-14601.
26. Kondo H, Toyoda JI. 1980. Dual effect of glutamate and aspartate on the on-center bipolar cell in the carp retina. Brain Res 199:240-243.
27. Lee CW, Park DJ, Lee KH, Kim CG, Rhee SG. 1993. Purification, molecular cloning, and sequencing of phospholipase C-beta 4. J Biol Chem 268:21318-21327.
28. Masland RH. 2001. Neuronal diversity in the retina. Curr Opin Neurobiol 11:431-436.
29. Mazuruk K, Schoen TJ, Chader GJ, Rodriguez IR. 1995. Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene. Biochem Biophys Res Commun 212:190-195.
30. McLaughlin SK, McKinnon PJ, Margolskee RF. 1992. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357:563-569.
31. Mora-Ferrer C, Yazulla S, Studholme KM, Haak-Frendscho M. 1999. Dopamine D1-receptor immunolocalization in goldfish retina. J Comp Neurol 411:705-714.
32. Morigiwa K, Vardi N. 1999. Differential expression of ionotropic glutamate receptor subunits in the outer retina. J Comp Neurol 405:173-184.
33. Nakajima Y, Iwakabe H, Akazawa C, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1993. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J Bio Chem 268:11868-11873.
34. Nawy S. 1999. The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells. J Neurosci 19:2938-2944.
35. Nawy S. 2000. Regulation of the on bipolar cell mGluR6 pathway by Ca2+. J Neurosci 20:4471-4479.
36. Nawy S, Jahr CE. 1990. Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells. Nature 346:269-271.
37. Pan ZH. 2000. Differential expression of high- and two types of low-voltage-activated calcium currents in rod and cone bipolar cells of the rat retina. J Neurophysiol 83:513-527.
38. Petrucci C, Resta V, Fieni F, Bigiani A, Bagnoli P. 2001. Modulation of potassium current and calcium influx by somatostatin in rod bipolar cells isolated from the rabbit retina via sst2 receptors. Naunyn Schmiedebergs Arch Pharmacol 363:680-694.
39. Ramon y Cajal. 1893. La rétine des vertébrés. La cellule 9:119-257.
40. Rossler P, Kroner C, Freitag J, Noe J, Breer H. 1998. Identification of a phospholipase C beta subtype in rat taste cells. Eur J Cell Biol 77:253-261.
41. Ruiz-Avila L, McLaughlin SK, Wildman D, McKinnon PJ, Robichon A, Spickofsky N, Margolskee RF. 1995. Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells. Nature 376:80-85.
42. Saito T, Kondo H. 1978. Ionic mechanisms underlying the center and surround responses of on-center bipolar cells in the carp retina. Sens Processes 2:350-358.
43. Saito T, Kujiraoka T. 1982. Physiological and morphological identification of two types of on-center bipolar cells in the carp retina. J Comp Neurol 205:161-170.
44. Saito T, Kondo H, Toyoda JI. 1979. Ionic mechanisms of two types of on-center bipolar cells in the carp retina. I. The responses to central illumination. J Gen Physiol 73:73-90.
45. Schwindinger WF, Robishaw JD. 2001. Heterotrimeric G-protein betagamma-dimers in growth and differentiation. Oncogene 20:1653-1660.
46. Shiells RA, Falk G. 1990. Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein. Proc R Soc Lond B 242:91-94.
47. Shiells RA, Falk G. 1994. Responses of rod bipolar cells isolated from dogfish retinal slices to concentration-jumps of glutamate. Vis Neurosci 11:1175-1183.
48. Ueda Y, Kaneko A, Kaneda M. 1992. Voltage-dependent ionic currents in solitary horizontal cells isolated from cat retina. J Neurophysiol 68:1143-1150.
49. Ueda Y, Iwakabe H, Masu M, Suzuki M, Nakanishi S. 1997. The mGluR6 5′ upstream transgene sequence directs a cell-specific and developmentally regulated expression in retinal rod and ON-type cone bipolar cells. J Neurosci 17:3014-3023.
50. Vardi N. 1998. Alpha subunit of G(o) localizes in the dendritic tips of ON bipolar cells. J Comp Neurol 395:43-52.
51. Vardi N, Matisic DF, Manning DR, Liebmann PA, Sterling P. 1993. Identification of a G-protein in depolarizing rod bipolar cells. Vis Neurosci 10:473-478.
52. Weng K, Lu C, Daggett LP, Kuhn R, Flor PJ, Johnson EC, Robinson PR. 1997. Functional coupling of a human retinal metabotropic glutamate receptor (hmGluR6) to bovine rod transducin and rat Go in an in vitro reconstitution system. J Biol Chem 272:33100-33104.
53. Werblin FS, Dowling JE. 1969. Organization of the retina of the mudpuppy, Necturus maculosus. II. Intracellular recording. J Neurophysiol 32:339-355.
54. Wong GT, Ruiz-Avila L, Margolskee RF. 1999. Directing gene expression to gustducin-positive taste receptor cells. J Neurosci 19:5802-5809.