Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure

European Journal of Medicinal Chemistry

Volumn 37, Issue 11, 2003, Pages 883-890

  Boussard, Cyrille ^a   Doyle, Valerie E ^a   Mahmood, Naheed ^b   Klimkait, Thomas ^c   Pritchard, Martyn ^d   Gilbert, Ian H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF BASEL   (Switzerland)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

CD4; Gp120; HIV; Inhibition; Interaction; Peptides

Indexed keywords

AMIDE; ANTIVIRUS AGENT; CD4 ANTIGEN; CHEMOKINE RECEPTOR; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN F(AB) FRAGMENT; PENTAPEPTIDE; PEPTIDE LIBRARY; PROTEIN INHIBITOR; RESIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PEPTIDE;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING ASSAY; CARBOXY TERMINAL SEQUENCE; CELL LINE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; REPORTER GENE; BINDING SITE; CELL FUSION; CELL MEMBRANE; CHEMISTRY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; IC 50; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-HIV AGENTS; ANTIGENS, CD4; BINDING SITES; CELL FUSION; CELL LINE; CELL MEMBRANE; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; INHIBITORY CONCENTRATION 50; PEPTIDE LIBRARY; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037210438     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01412-5     Document Type: Article

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