Investigations on the synthesis and pharmacological properties of 4-alkoxy-2-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl]-6-methyl-1H-pyrrolo [3,4-c]pyridine-1,3(2H)-diones

Farmaco

Volumn 57, Issue 11, 2002, Pages 897-908

  śladowska, Helena ^a   Filipek, Barbara ^b   Szkatuła, Dominika ^a   Sabiniarz, Aleksandra ^a   Kardasz, Małgorzata ^b   Potoczek, Joanna ^a   Sieklucka Dziuba, Maria ^c   Rajtar, Grazyna ^c   Kleinrok, Zdzisław ^c   Lis, Tadeusz ^d  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d UNIVERSITY OF WROC AW   (Poland)

Author keywords

4 Alkoxy 6 methyl 1H pyrrolo 3,4 c pyridine 1,3(2H) diones; Analgesic and sedative activities; Derivatives of 7 aza 4 azoniaspiro 3.5 nonane chloride; N 2 hydroxy 3 (4 aryl 1 piperazinyl)propyl derivatives; Synthesis

Indexed keywords

ANALGESIC AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PIPERAZINE DERIVATIVE; PYRIDONE DERIVATIVE; PYRROLE DERIVATIVE; ACETYLSALICYLIC ACID; PYRIDINE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD PRESSURE; CHEMICAL STRUCTURE; CONFORMATION; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; MOTOR ACTIVITY; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PAIN ASSESSMENT; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WISTAR RAT; X RAY CRYSTALLOGRAPHY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EXPERIMENTAL TEST; ISOMERISM; LOCOMOTION; NONHUMAN;

ANALGESICS, NON-NARCOTIC; ANIMALS; BLOOD PRESSURE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOTOR ACTIVITY; PAIN MEASUREMENT; PIPERAZINES; PYRIDONES; PYRROLES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037210220     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)01302-2     Document Type: Article

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