Investigations on the synthesis and properties of some N-[4-phenyl(2-pyrimidinyl)-1-piperazinyl]alkyl (hydroxyalkyl)-3,4-pyridinedicarboximides

Acta Poloniae Pharmaceutica - Drug Research

Volumn 53, Issue 6, 1996, Pages 417-424

  Śladowska, Helena ^a   Potoczek, Joanna ^a   Rajtar, Grazyna ^b   Sieklucka Dziuba, Maria ^b   Zółkowska, Dorota ^b   Kleinrok, Zdzisław ^b  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

2 Substituted 3,4 pyridinedicarboximides; N (4 phenyl 1 piperazinyl)alkyl 3,4 pyridinedicarboximide derivatives; N 2 hydroxy 3 4 phenyl(2 pyrimidinyl) 1 piperazinyl propyl 3,4 Pyridinedicarboximide derivatives; Pharmacological screening; Synthesis

Indexed keywords

ANXIOLYTIC AGENT; N [4 PHENYL(2 PYRIMIDINYL) 1 PIPERAZINYL]ALKYL(HYDROXYALKYL) 3,4 PYRIDINEDICARBOXIMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM DEPRESSION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; RAT;

ANIMALS; BLOOD PRESSURE; CENTRAL NERVOUS SYSTEM; DRUG EVALUATION, PRECLINICAL; FEMALE; HETEROCYCLIC COMPOUNDS, 1-RING; IMIDES; LETHAL DOSE 50; MALE; MICE; MOTOR ACTIVITY; PYRIMIDINES; RATS; RATS, WISTAR;

EID: 0030474504     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Śladowska H., Sieklucka-Dziuba M., Misztal M., Kleinrok Z.: Il Farmaco 49, 493 (1994).
2. Śladowska H., Potoczek J., Sieklucka-Dziuba M., Semczuk A., Kleinrok Z.: Il Farmaco 50, 761 (1995).
3. Dobeneck H., Hansen B.: Chem. Ber. 105, 3611 (1972).
4. Johnson R.S., Lovett T.D., Stevens T.S.: J. Chem. Soc. (C) 796 (1970).
5. Litchfield J.T., Wilcoxon F.: J. Pharmacol. Exp. Ther. 96, 99 (1949).
6. Gross F., Tripod J., Meier R.: Med. Wschr. 85, 305 (1955).
7. Witkin L., Heubner G., Galdi F., O'Keefe E., Spitaletta F., Plumer A.: J. Pharmacol. Exp. Ther. 133, 400 (1951).
8. Eddy N.B., Leimbach D.: J. Pharmacol. Exp. Ther. 107, 385 (1953).
9. Aron C., Simon D., Larousse C., Boissier J.R.: Neuropharmacology 10, 459 (1971).
10. Swinyard E.A., Brwon W.C., Goodman L.S.: J. Pharmacol. Exp. Ther. 106, 319 (1952).
11. Gerold M., Tschirky H.: Arzneimittelforschung 18, 1285 (1968).