Apoptosis in relation to CD34 antigen expression in normal and myelodysplastic bone marrow

Acta Haematologica

Volumn 109, Issue 1, 2003, Pages 29-34

  Pecci, Alessandro ^a,b   Travaglino, Erica ^a   Klersy, Catherine ^b   Invernizzi, Rosangela ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Apoptosis; CD34 antigen; Myelodysplastic syndromes; Stem cell

Indexed keywords

CD34 ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MALE; MYELODYSPLASTIC SYNDROME; NICK END LABELING; PRIORITY JOURNAL; BONE MARROW; BONE MARROW CELL; CASE CONTROL STUDY; CELL DIFFERENTIATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; STATISTICAL ANALYSIS;

AGED; AGED, 80 AND OVER; ANTIGENS, CD34; APOPTOSIS; BONE MARROW; BONE MARROW CELLS; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; DATA INTERPRETATION, STATISTICAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES;

EID: 0037209066     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067275     Document Type: Article

References (25)

1. Greenberg PL: The myelodysplastic syndromes; in Hoffman R, Benz E, Shattil S, Furie B, Cohen H (ed): Hematology: Basic Principles and Practice. New York, Churchill Livingstone, 1994, pp 1098-1121.
2. Koeffler HP: Myelodysplastic syndromes. Semin Hematol 1996;33:87-94.
3. Aul C, Bowen DT, Yoshida Y: Pathogenesis, etiology and epidemiology of myelodysplastic syndromes. Haematologica 1998;83:71-86.
4. Yoshida Y: Hypothesis: Apoptosis may be the mechanism responsible for the premature intramedullary cell death in the myelodysplastic syndrome. Leukemia 1993;7:144-146.
5. Greenberg PL: Apoptosis and its role in the myelodysplastic syndromes: Implication for disease natural history and treatment. Leuk Res 1998;22:1123-1136.
6. Parker JE, Mufti GJ: Ineffective haemopoiesis and apoptosis in myelodysplastic syndromes. Br J Haematol 1998;101:220-230.
7. Yoshida Y, Mufti GJ: Apoptosis and its significance in MDS: Controversies revisited. Leuk Res 1999;23:777-785.
8. Rajapaksa R, Ginzton N, Lusijah SR, Greenberg PL: Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood 1996;88:4275-4287.
9. Bouscary D, De Vos J, Guesnu M, Jondeau K, Viguier F, Melle J, Picard F, Dreyfus F, Fontenay-Roupie M: Fas/Apo-1(CD95) expression and apoptosis in patients with myelodysplastic syndromes. Leukemia 1997;11:839-845.
10. Kitagawa M, Yamaguchi S, Takahashi M, Tanizawa T, Hirokawa K, Kamiyama R: Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia. Leukemia 1998;12:486-492.
11. Parker JE, Fishlock KL, Mijovic A, Czepulkowski B, Pagliuca A, Mufti GJ: 'Low-risk' myelodysplastic syndrome is associated with excessive apoptosis and an increased ratio of pro- versus anti-apoptotic bcl-2-related proteins. Br J Haematol 1998;103:1075-1082.
12. Mundle S, Venugopal P, Shetty V, Ali A, Chopra H, Handa H, Rose S, Mativi BY, Gregory SA, Preisler HD, Raza A: The relative extent and propensity of CD34+ vs. CD34- cells to undergo apoptosis in myelodysplastic marrows. Int J Hematol 1999;69:152-159.
13. Tsoplou P, Kouraklis-Symeonidis A, Thanopoulou E, Zikos P, Orphanos V, Zoumbos NC: Apoptosis in patients with myelodysplastic syndromes: Differential involvement of marrow cells in 'good' versus 'poor' prognosis patients and correlation with apoptosis-related genes. Leukemia 1999;13:1554-1563.
14. Matthes TW, Meyer G, Samii K, Beris P: Increased apoptosis in acquired sideroblastic anemia. Br J Haematol 2000;111:843-852.
15. Parker JE, Mufti GJ, Rasool F, Mijovic A, Devereux S, Pagliuca A: The role of apoptosis, proliferation and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood 2000; 96:3932-3938.
16. Novitzky N, Mohamed R, Finlayson J, du Toit C: Increased apoptosis of bone marrow cells and preserved proliferative capacity of selected progenitors predict for clinical response to anti-inflammatory therapy in myelodysplastic syndromes. Exp Hematol 2000;28:941-949.
17. Hellstrom-Lindberg E, Schmidt-Mende J, Forsblom AM, Christensson B, Fadeel B, Zhivotovsky B: Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases. Br J Haematol 2001;112:714-726.
18. Berger G, Hunault-Berger M, Rachieru P, Fontenay-Roupie M, Baranger L, Ifrah N, Zandecki M: Increased apoptosis in mononucleated cells but not in CD34+ cells in blastic forms of myelodysplastic syndromes. Hematol J 2001;2:87-96.
19. Raza A, Gezer S, Mundle S, Gao X, Alvi S, Borok R, Rifkin S, Iftikhar A, Shetty V, Parcharidou A, Loew J, Marcus B, Khan Z, Chaney C, Showel J, Gregory S, Preisler H: Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood 1995; 86:268-276.
20. Tsouplou P, Zoumbos N: Programmed cell death (PCD) in the marrow of patients with myelodysplastic and myeloproliferative diseases concerns almost exclusively CD34+ cells. Blood 1996;88(suppl 1):95a.
21. Ricciardi MR, Petrucci MT, Ariola C, Gregorj C, Mazzola R, Latagliata R, Petti MC, Tafuri A: High levels of apoptosis characterize RAEB and are lost during leukemic transformation. Blood 1997;90(suppl 1):520a.
22. Invernizzi R, Pecci A, Bellotti L, Ascari E: Expression of p53, bcl-2 and ras oncoproteins and apoptosis levels in acute leukemias and myelodysplastic syndromes. Leuk Lymphoma 2001;42:481-489.
23. Lepelley P, Campergue L, Grardel N, Preudhomme C, Cosson A, Fenaux P: Is apoptosis a massive process in myelodysplastic syndromes? Br J Haematol 1996;95:368-371.
24. Kroemer G, Petit P, Zamzami N, Vayssiere JL, Mignotte B: The biochemistry of programmed cell death. FASEB J 1995;9:1277-1287.
25. Shetty V, Hussaini S, Broady-Robinson L, Allampallam K, Mundle S, Borok R, Broderick E, Mazzoran L, Zorat F, Raza A: Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: Apoptotic cells recovered from high-density fraction of bone marrow aspirates. Blood 2000; 96:1388-1392.