Ets-2 Respressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells

Journal of General Virology

Volumn 84, Issue 1, 2003, Pages 41-49

  Bain, Mark ^a   Mendelson, Marc ^a,b   Sinclair, John ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

IMMEDIATE EARLY PROTEIN; TRANSCRIPTION FACTOR ETS 2; DNA BINDING PROTEIN; ERF PROTEIN, HUMAN; ETS2 PROTEIN, HUMAN; ONCOPROTEIN; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

CARCINOMA CELL; CELL DIFFERENTIATION; DOWN REGULATION; EMBRYO CELL; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; LATENT VIRUS INFECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; ARTICLE; CELL CULTURE; CYTOMEGALOVIRUS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHYSIOLOGY; TERATOCARCINOMA; VIRUS LATENCY;

ANIMALIA; CYTOMEGALOVIRUS; DNA VIRUSES; HUMAN HERPESVIRUS 5;

CELL DIFFERENTIATION; CYTOMEGALOVIRUS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; IMMEDIATE-EARLY PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEIN C-ETS-2; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; TERATOCARCINOMA; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; VIRUS LATENCY;

EID: 0037208004     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.18633-0     Document Type: Review

References (48)

1. Alford, C. A. & Britt, W. J. (1993). Cytomegalovirus. In The Human Herpesviruses pp. 227-255. Edited by B. Roizman, R. J. Whitely & C. Lopez. New York: Raven Press.
2. Andrews, P. W., Damjanov, I., Simon, D., Banting, G. S., Carlin, C., Dracopoli, N. C. & Fogh, J. (1984). Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Lab Invest 50, 147-162.
3. Austen, M., Luscher, B. & Luscher-Firzlaff, J. M. (1997). Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein (CBP)-binding protein. J Biol Chem 272, 1709-1717.
4. Chan, Y. J., Chiou, C. J., Huang, O. & Hayward, G. S. (1996). Synergistic interactions between overlapping binding sites for the serum response factor and ELK-1 proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus major immediate-early promoters in monocyte and T-lymphocyte cell types. J Virol 70, 8590-8605.
5. Dittmer, J. & Nordheim, A. (1998). Ets transcription factors and human disease. Biochim Biophys Acta 1377, F1-11.
6. Donohoe, M. E., Zhang, X., McGinnis, L., Biggers, J., Li, E. & Shi, Y. (1999). Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol 19, 7237-7244.
7. Galvagni, F., Cartocci, E. & Oliviero, S. (1998). The dystrophin promoter is negatively regulated by YY1 in undifferentiated muscle cells. J Biol Chem 273, 33708-33713.
8. Gonczol, E., Andrews, P. W. & Plotkin, S. A. (1984). Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells. Science 224, 159-161.
9. Hagemeier, C., Bannister, A. J., Cook A. & Kouzarides, T. (1993). The activation domain of transcription factor PU. 1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc Natl Acad Sci U S A 90, 1580-1584.
10. Huang, T. H., Oka, T., Asai, T., Okada, T., Merrills, B. W., Gertson, P. N., Whitson, R. H. & Itakura, K. (1996). Repression by a differentiation-specific factor of the human cytomegalovirus enhancer. Nucleic Acids Res 24, 1695-1701.
11. Klemsz, M. J., McKercher, S. R., Celada, A., Van, B. C. & Maki, R. A. (1990). The macrophage and B cell-specific transcription factor PU. 1 is related to the ets oncogene. Cell 61, 113-124.
12. Kothari, S., Baillie, J., Sissons, J. G. & Sinclair, J. H. (1991). The 21 bp repeat element of the human cytomegalovirus major immediate early enhancer is a negative regulator of gene expression in undifferentiated cells. Nucleic Acids Res 19, 1767-1771.
13. Le, G. L., Sgouras, D., Beal, G. J. & Mavrothalassitis, G. (1999). Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation. Mol Cell Biol 19, 4121-4133.
14. Lee, T. C., Zhang, Y. & Schwartz, R. J. (1994). Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis. Oncogene 9, 1047-1052.
15. Liu, R., Baillie, J., Sissons, J. G. & Sinclair, J. H. (1994). The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in non-permissive cells. Nucleic Acids Res 22, 2453-2459.
16. Liu, D., Pavlopoulos, E., Modi, W., Moschonas, N. & Mavrothalassitis, G. (1997). ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes. Oncogene 14, 1445-1451.
17. Lubon, H., Ghazal, P., Hennighausen, L., Reynolds-Kohler, C., Lockshin, C. & Nelson, J. (1989). Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene. Mol Cell Biol 9, 1342-1345.
18. Malone, C. L., Vesole, D. H. & Stinski, M. F. (1990). Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins. J Virol 64, 1498-1506.
19. Martin, M. E., Piatte, J., Yaniv, M., Tang, W. J. & Folk, W. R. (1988). Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins. Proc Natl Acad Sci U S A 85, 5839-5843.
20. Mavrothalassitis, G. & Ghysdael, J. (2000). Proteins of the ETS family with transcriptional repressor activity. Oncogene 19, 6524-6532.
21. Meier, J. L. (2001). Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator. J Virol 75, 1581-1593.
22. Meier, J. L. & Pruessner, J. A. (2000). The human cytomegalovirus major immediate-early distal enhancer region is required for efficient viral replication and immediate-early gene expression. J Virol 74, 1602-1613.
23. Meier, J. L. & Stinski, M. F. (1996). Regulation of human cytomegalovirus immediate-early gene expression. Intervirology 39, 331-342.
24. Meier, J. L. & Stinski, M. F. (1997). Effect of a modulator deletion on transcription of the human cytomegalovirus major immediate-early genes in infected undifferentiated and differentiated cells. J Virol 71, 1246-1255.
25. Meier, J. L., Keller, M. J. & McCoy, J. J. (2002). Requirement of multiple cis-acting elements in the human cytomegalovirus major immediate-early distal enhancer for viral gene expression and replication. J Virol 76, 313-326.
26. Murphy, J. C., Fischle, W., Verdin, E. & Sinclair, J. H. (2002). Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J 21, 1112-1120.
27. Nelson, J. A., Reynolds-Kohler, C. & Smith, B. A. (1987). Negative and positive regulation by a short segment in the 5′-flanking region of the human cytomegalovirus major immediate-early gene. Mol Cell Biol 7, 4125-4129.
28. Pizzorno, M. C. (2001). Nuclear cathepsin B-like protease cleaves transcription factor YY1 in differentiated cells. Biochim Biophys Acta 1536, 31-42.
29. Pizzorno, M. C., O'Hare, P., Sha, L., LaFemina, R. L. & Hayward, G. S. (1988). Trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus. J Virol 62, 1167-1179.
30. Sambrook, J., Fritsch, E. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
31. Seto, E., Shi, Y. & Shenk, T. (1991). YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro. Nature 354, 241-245.
32. Sgouras, D. N., Athanasiou, M. A., Beal, G. J. J., Fisher, R. J., Blair, D. G. & Mavrothalassitis, G. J. (1995). ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. EMBO J 14, 4781-4793.
33. Shelbourn, S. L., Kothari, S. K., Sissons, J. G. & Sinclair, J. H. (1989). Repression of human cytomegalovirus gene expression associated with a novel immediate early regulatory region binding factor. Nucleic Acids Res 17, 9165-9171.
34. Shi, Y., Lee, J. S. & Galvin, K. M. (1997). Everything you have ever wanted to know about Yin Yang 1. Biochim Biophys Acta 1332, F49-66.
35. Sinclair, J. H. (1999). Sites and mechanisms of latency of human cytomegalovirus. In Frontiers in Molecular Biology: DNA Virus Replication, pp. 156-172. Edited by A. J. Cann. Oxford: Oxford University Press.
36. Sissons, J. G., Bain, M. & Wills, M. R. (2002). Latency and reactivation of human cytomegalovirus. J Infect 44, 73-77.
37. Soderberg-Naucler, C., Fish, K. N. & Nelson, J. A. (1997). Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 91, 119-126.
38. Taylor-Wiedeman, J., Sissons, J. G., Borysiewicz, L. K. & Sinclair, J. H. (1991). Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J Gen Virol 72, 2059-2064.
39. Taylor-Wiedeman, J., Sissons, P. & Sinclair, J. (1994). Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers. J Virol 68, 1597-1604.
40. Thomas, M. J. & Seto, E. (1999). Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene 236, 197-208.
41. Usheva, A. & Shenk, T. (1994). TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA. Cell 76, 1115-1121.
42. Walowitz, J. L., Bradley, M. E., Chen, S. & Lee, T. (1998). Proteolytic regulation of the zinc finger transcription factor YY1, a repressor of muscle-restricted gene expression. J Biol Chem 273, 6656-6661.
43. Wasylyk, C. & Wasylyk, B. (1992). Oncogenic conversion alters the transcriptional properties of ets. Cell Growth & Differ 3, 617-625.
44. Wasylyk, C., Flores, P., Gutman, A. & Wasylyk, B. (1989). PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes. EMBO J 8, 3371-3378.
45. Wasylyk, B., Wasylyk, C., Flores, P., Begue, A., Leprince, D. & Stehelin, D. (1990). The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation. Nature 346, 191-193.
46. Weinshenker, B. G., Wilton, S. & Rice, G. P. (1988). Phorbol ester-induced differentiation permits productive human cytomegalovirus infection in a monocytic cell line. J Immunol 140, 1625-1631.
47. Yao, Y. L., Dupont, B. R., Ghosh, S., Fang, Y., Leach, R. J. & Seto, E. (1998). Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1. Nucleic Acids Res 26, 3776-3783.
48. Yao, Y. L., Yang, W. M. & Seto, E. (2001). Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol 21, 5979-5991.