Is the APOE ε4 genotype associated with higher hospital costs among elderly patients?

American Journal of Geriatric Psychiatry

Volumn 11, Issue 1, 2003, Pages 75-82

  Taylor Jr , Donald H ^a   Fillenbaum, Gerda ^a   Burchett, Bruce ^a   Blazer, Dan G ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; APOLIPOPROTEIN E;

ARTICLE; ELDERLY CARE; FAMILY HISTORY; GENETIC ASSOCIATION; GENOTYPE; HEALTH CARE UTILIZATION; HEALTH INSURANCE; HOSPITAL COST; HOSPITALIZATION; MEDICARE; MULTIGENE FAMILY; OUTCOMES RESEARCH; PATIENT CARE; REIMBURSEMENT; AGED; ALLELE; ALZHEIMER DISEASE; CLINICAL TRIAL; COHORT ANALYSIS; ECONOMICS; FEMALE; GENETICS; HEALTH CARE COST; HUMAN; MALE; MULTICENTER STUDY; PROSPECTIVE STUDY;

AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; COHORT STUDIES; FEMALE; GENOTYPE; HEALTH CARE COSTS; HOSPITALIZATION; HUMANS; MALE; MEDICARE; PROSPECTIVE STUDIES;

EID: 0037207970     PISSN: 10647481     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019442-200301000-00010     Document Type: Article

References (32)

1. Holtzman NA: Benefits and risks of emerging genetic technologies: the need for regulation. Clin Chem 1994; 40:1652-1657
2. Mayeux R, Schupf N: Apolipoprotein-E and Alzheimer's disease: the implications of progress in molecular medicine. Am J Public Health 1995; 85:1280-1284
3. Fleck LM: Just caring: the moral and economic costs of APOE genotyping for Alzheimer's disease. Ann N Y Acad Sci 1996; 802:128-138
4. Kapp M: Medico-legal, employment, and insurance issues in APOE genotyping and Alzheimer's disease. Ann N Y Acad Sci 1996; 802:139-147
5. Post SG: On not jumping the gun: ethical aspects of APOE gene testing for Alzheimer's disease. Ann N Y Acad Sci 1996; 802:111-119
6. Frisoni G, Bianchetti A, Trabucchi M: Apolipoprotein-E and the cost of Alzheimer's disease. Int J Geriatr Psychiatry 1997; 12:588-589
7. Karlawish JHT, Sachs GA: APOE 4 testing for Alzheimer's disease. Journal of the American Psychological Society 1997; 45:1153-1159
8. Roses AD: Genetic testing for Alzheimer disease: practical and ethical issues. Arch Neurol 1997; 54:1226-1229
9. de Knijff P, van Duijn CM: Role of APOE in dementia: a critical reappraisal. Haemostasis 1998; 28:195-201
10. Lovestone S: Early diagnosis and the clinical genetics of Alzheimer's disease. J Neurol 1999; 246:69-72
11. Tsuang D, Larson EB, Bowen J, et al: The utility of apolipoprotein-E genotyping in the diagnosis of Alzheimer's disease in a community based case series. Arch Neurol 1999; 56:1489-1495
12. Natowicz MR, Alper JK, Alper JS: Genetic discrimination and the law. Am J Hum Genet 1992; 50:465-475
13. Dickens B: Legal issues in predictive genetic testing programs: Alzheimer Dis Assoc Disord 1994; 8:94-101
14. Billings PR, Kohn MA, de Cuevas M, et al: Discrimination as a consequence of genetic testing. Am J Hum Genet 1992; 50:476-482
15. Ostrer H, Allen W, Crandall LA, et al: Insurance and genetic testing: where are we now? Am J Hum Genet 1993; 52:565-577
16. Gostin L: Genetic discrimination: the use of genetically based diagnostic and prognostic tests by employers and insurers. Am J Law Med 1991; 17:109-144
17. Van Crevel H, van Gool WA, Walstra GJM: Early diagnosis of dementia: which tests are indicated? what are their costs? J Neurol 1999; 246:73-78
18. Cornoni-Huntley J, Blazer D, Lafferty M, et al: Established Populations for Epidemiologic Studies of the Elderly: Resource Data Book, Vol. II. Bethesda, MD, National Institute on Aging, 1990
19. Blazer D, Burchett B, Service C, et al: The association of age and depression among the elderly: an epidemiological exploration. J Gerontol Med Sci 1991; 46:M210-M215
20. Cornoni-Huntley J, Brock D, Ostfeld A, et al: Established Populations for Epidemiologic Studies of the Elderly: Resource Data Book. Bethesda, MD, National Institute on Aging, 1986
21. Pfeiffer E: A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc 1975; 23:433-441
22. Radloff L: The CES-D Scale: a self-report depression scale for research in the general population. Applied Psychological Measurement 1977; 1:385-401
23. Fillenbaum, G, Liess J, Pieper C, et al: Developing a summary scale of medical status. Aging: Exp Soc Res 1998; 10:395-400
24. Fillenbaum G, Blazer D, Burchett B, et al. Apolipoprotein ε4 and risk of mortality in African American and white older community residents. Gerontologist 2002; 42:381-386
25. Chernick MR: Bootstrap Methods: A Practitioner's Guide. New York, Wiley, 1999
26. Efron B, Tibshirani R: An Introduction to the Bootstrap. New York, Chapman & Hall, 1993
27. Gould WW: Quantile regression with bootstrapped standard errors. Stata Technical Bulletin 1992; 9:19-21; College Station, TX, Stata Corporation, 1992
28. Fillenbaum GC: Multidimensional functional assessment of older adults: the Duke Older Americans Resources and Services Procedures. Hillsdale, NJ, Lawrence Erlbaum Associates, 1988
29. Taylor Jr. DH, Schenkman M, Zhou J, et al: The relative effect of Alzheimer's disease and related dementias, disability, and comorbidities on cost of care for elderly persons. J Gerontol Psychol Sci Soc Sci 2001; 56B:S285-S293
30. McCarron MO, DeLong D, Alberts MJ: APOE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis. Neurology 1999; 53:1308-1311
31. Lambert JC, Borusseau T, Defosse V, et al: Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations: the ECTIM study. Hum Genet 2000; 9:57-61
32. Taylor Jr. DH, Whellan D, Sloan FA: Effects of admission to a teaching hospital on cost and quality of care: evidence from Medicare. New Engl J Med 1999; 318:293-299