Induction of metallothionein by zinc protects from daunorubicin toxicity in rats

Toxicology

Volumn 179, Issue 1-2, 2002, Pages 85-93

  Ali, Mamdouh M ^a   Frei, Eva ^b   Straub, Josef ^b   Breuer, Andrea ^b   Wiessler, Manfred ^b  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Cardiotoxicity; Competitive quantitative RT PCR; Daunorubicin; Hepatotoxicity; Metallothionein; MT 1 mRNA; Reactive oxygen species; Western blot; Zinc

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTHRACYCLINE ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; CREATINE KINASE; DAUNORUBICIN; ISOPROTEIN; MESSENGER RNA; METALLOTHIONEIN; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TROPONIN T; ZINC CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CHEMOTHERAPY; CONTROLLED STUDY; DRUG MECHANISM; DRUG METABOLISM; ENZYME ACTIVITY; HEART; LIPID PEROXIDATION; LIVER; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INDUCTION; RAT;

ALANINE TRANSAMINASE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, WESTERN; CREATINE KINASE; DAUNORUBICIN; ENZYME INDUCTION; ISOENZYMES; LIPID PEROXIDATION; LIVER; MALE; METALLOTHIONEIN; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TROPONIN T; ZINC;

ANIMALIA;

EID: 0037200841     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00322-0     Document Type: Article

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