Basal and drug-induced antioxidant enzyme activities correlate with age- dependent doxorubicin oxidative toxicity

Chemico-Biological Interactions

Volumn 127, Issue 1, 2000, Pages 1-11

  Pritsos, Chris A ^a   Ma, J ^a  

^a UNIVERSITY OF NEVADA   (United States)

Author keywords

Age; Anthracyclines; Antioxidant enzymes; Doxorubicin; Lipid peroxidation; Oxidative stress

Indexed keywords

ANTIOXIDANT; CATALASE; DOXORUBICIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; HEART; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

AGING; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BRAIN; DOXORUBICIN; ENZYMES; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; MYOCARDIUM; OXIDATIVE STRESS; RATS; RATS, INBRED F344;

ANIMALIA; MARTES PENNANTI;

EID: 0034659118     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00159-9     Document Type: Article

References (26)

1. Fu L.X., Waagstein F., Hjalmarson A. A new insight into adraimycin-induced cardiotoxicity. Int. J. Cardiol. 29:1990;15-20.
2. Singal P.K., Deally C.M.R., Weinberg L.E. Subcellular effects of adriamycin in the heart: a concise review. J. Mol. Cell. Cardiol. 19:1987;817-828.
3. Azuma J., Sperelakis N., Hasegawa H. et al. Adriamycin cardiotoxicity: possible pathogenic mechanisms. J. Mol. Cell. Cardiol. 13:1981;381-397.
4. Pratt C.B., Ransom L.L., Evans W.X. Age-related adriamycin cardiotoxicity in children. Cancer Treat. Rep. 62:1978;1381-1385.
5. Von Hoff D.D., Layard M.W., Basa P., Davis H.L. Jr., Von Hoff A.L., Rozencweig M., Muggia F.M. Risk factors for doxorubicin-induced congestive heart failure. Ann. Intern. Med. 91:1979;710-717.
6. Weinberg L.E., Singal P.K. Refractory heart failure and age-related differences in adriamycin-induced myocardial changes in rats. Can. J. Physiol. Pharmacol. 65:1987;1957-1965.
7. Deally C.M.R., Singal P.K. Susceptibility to adriamycin-induced cardiotoxicity increases only up to certain age. J. Appl. Cardiol. 5:1990;223-238.
8. Matsumura M., Nishioka K., Fujii T., Yoshibayashi M., Nozaki K., Nakata Y., Temma S., Ueda T., Ntikawa H. Age-related acute adriamycin cardiotoxicity in mice. J. Mol. Cell. Cardiol. 26:1994;899-905.
9. Della Torre P., Mazue G., Podesta A., Moneta D., Sammartini U., Imondi A.R. Protection against doxorubicin-induced cardiotoxicity in weanling rats by dexrazoxane. Cancer Chemother. Pharmacol. 43:1999;151-156.
10. Colombo T., Donelli M.G., Urso R., Dallarda S., Bartosek I., Guaitani A. Doxorubicin toxicity and phannacokinetics in old and young rats. Exp. Gerontol. 24:1989;159-171.
11. Bachur N.R., Gordon S.L., Gee M.V. Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation. Mol. Pharmacol. 13:1977;901-910.
12. Meyers C.E., McGuire W.P., Liss R.H., Ifrim I., Grotzinger K., Young R.C. Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response. Science. 197:1977;165-167.
13. Mimnaugh E.G., Trush M.A., Gram T.E. Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation. Biochem. Pharmacol. 30:1981;2797-2804.
14. Olson R.D., Boerth R.C., Gerber L.G., Nies A.S. Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress. Life. Sci. 29:1981;1393-1401.
15. Davies K.L.A., Doroshow J.H. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J. Biol. Chem. 261:1986;3060-3067.
16. Bachur N.R., Gordon S.L., Gee M.V. A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res. 38:1978;1745-1750.
17. Doroshow J.H., Locker G.Y., Meyers C.E. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J. Clin. Invest. 65:1980;128-135.
18. Goodman J., Hochstein P. Generation of free radicals and lipid peroxidation by redox cycling of Adriamycin and daunomycin. Biochem. Biophys. Res. Commun. 77:1977;797-803.
19. McCord J.M., Fridovich I. Superoxide dismutase. J. Biol. Chem. 244:1969;6049-6055.
20. Oberley L.W., Spitz D.R. Assay of superoxide dismutase activity in tumor tissue. Methods Enzymol. 105:1984;457-465.
21. Aebi H. Catalase in vitro. Methods Enzymol. 105:1984;121-126.
22. Strauss R.S., Synder E.L., Wallace P.D., Rosenberger T.G. Oxygen detoxifying enzymes in neutrophils of infants and their mothers. J. Lab. Clin. Invest. 95:1980;897-904.
23. Racker E. Glutathione reductase (liver and yeast). Methods Enzymol. 2:1955;722-727.
24. Wills E.D. Evaluation of lipid peroxidation in lipids and biological membranes. Snell K., Mullock B. Biochemical Toxicology. 1987;127-152 IRL Press, Washington, DC.
25. Balducci L., Extermann M. Cancer chemotherapy in the older patient. Cancer. 80:1997;1317-1322.
26. Robert J., Hoemi B. Age dependence of the early-phase pharmacokinetics of doxorubicin. Cancer Res. 43:1983;4467-4469.