A reeler mutant mouse with a new, spontaneous mutation in the reelin gene

Molecular Brain Research

Volumn 105, Issue 1-2, 2002, Pages 153-156

  Andersen, Tom E ^a,c   Finsen, Bente ^a   Goffinet, Andre M ^b   Issinger, Olaf Georg ^a   Boldyreff, Brigitte ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Mutation; Neuronal migration; Reelin; Reln

Indexed keywords

REELIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DATA BASE; EXON; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENETIC COMPLEMENTATION; MOUSE; MOUSE MUTANT; NONHUMAN; NORTHERN BLOTTING; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; SPONTANEOUS MUTATION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; CELL ADHESION MOLECULES, NEURONAL; CEREBELLUM; DNA; DOWN-REGULATION; EXONS; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE DELETION; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MUTATION; NERVE TISSUE PROTEINS; PHENOTYPE; RNA, MESSENGER; SERINE ENDOPEPTIDASES;

EID: 0037200816     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(02)00389-3     Document Type: Article

References (20)

1. Bar I., De Rouvroit C.L., Royaux I., Krizman D.B., Dernoncourt C., Ruelle D., Beckers M.C., Goffinet A.M. A YAC contig containing the reeler locus with preliminary characterization of candidate gene fragments. Genomics. 26:1995;543-549.
2. Bar I., Goffinet A.M. Decoding the reelin signal. Nature. 399:1999;645-646.
3. Caviness V.S.J., Crandall J.E., Edwards M.A. The reeler malformation. Implications for neocortical histogenesis. Peters A., Jones E.G., Cerebral Cortex. Development and Maturation of Cerebral Cortex. Vol. 7:1988;59-89 Plenum, New York.
4. Chae T., Kwon Y.T., Bronson R., Dikkes P., Li E., Tsai L.H. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron. 18:1997;29-42.
5. D'Arcangelo G., Miao G.G., Chen S.C., Doares H.D., Morgan J.I., Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 374:1995;719-723.
6. D'Arcangelo G., Miao G.G., Curran T. Detection of the reelin breakpoint in reeler mice. Brain Res. Mol. Brain Res. 39:1996;234-236.
7. de Bergeyck V., Nakajima K., de Rouvroit C.L., Naerhuyzen B., Goffinet A.M., Miyata T., Ogawa M., Mikoshiba K. A truncated Reelin protein is produced but not secreted in the 'Orleans' reeler mutation (Reln[rl-Orl]). Brain Res. Mol. Brain Res. 50:1997;85-90.
8. Falconer D.S. Two new mutants, 'Trembler' and 'Reeler', with neurological actions in the house mouse. J. Genet. 50:1951;192-201.
9. Flaherty L., Messer A., Russel L.B., Rinchik E.M. Chlorambucil-induced mutations in mice recovered in homozygotes. Proc. Natl. Acad. Sci. USA. 89:1992;2859-2863.
10. Hedegaard-Pedersen H., Boldyreff B., Vach W., van der Meer M., Ristkes-Hoitinga M. Behavioural tests in the B6D2F2.PKCK/β mouse: preliminary study. Proceedings of the International XII ICLAS and VII FELASA Joint Meeting:2000;218-220.
11. Howell B.W., Hawkes R., Soriano P., Cooper J.A. Neuronal position in the developing brain is regulated by mouse disabled-1. Nature. 389:1997;733-737.
12. Impagnatiello F., Guidotti A.R., Pesold C., Dwivedi Y., Caruncho H., Pisu M.G., Uzonov D.P., Smalheiser N.R., Davis J.M., Pandey G.N., Pappas G.D., Tueting P., Sharma R.P., Costa E. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc. Natl. Acad. Sci. USA. 95:1998;15718-15723.
13. Miao G.G., Smeyne R.J., D'Arcangelo G., Copeland N.G., Jenkins N.A., Morgan J.I., Curran T. Isolation of an allele of reeler by insertional mutagenesis. Proc. Natl. Acad. Sci. USA. 91:1994;11050-11054.
14. Ohshima T., Ward J.M., Huh C.G., Longenecker G., Veeranna, Pant H.C., Brady R.O., Martin L.J., Kulkarni A.B. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. USA. 93:1996;11173-11178.
15. rl-Alb2, an allele of reeler isolated from a chlorambucil screen, is due to an IAP insertion with exon skipping. Genomics. 42:1997;479-482.
16. Sheldon M., Rice D.S., D'Arcangelo G., Yoneshima H., Nakajima K., Mikoshiba K., Howell B.W., Cooper J.A., Goldowitz D., Curran T. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature. 389:1997;730-733.
17. Sweet H.O. Remutations at The Jackson Laboratory. Mouse Genome. 91:1993;862-865.
18. Takahara T., Ohsumi T., Kuromitsu J., Shibata K., Sasaki N., Okazaki Y., Shibata H., Sato S., Yoshiki A., Kusakabe M., Muramatsu M., Ueki M., Okuda K., Hayashizaki Y. Dysfunction of the Orleans reeler gene arising from exon skipping due to transposition of a full-length copy of an active L1 sequence into the skipped exon. Hum. Mol. Genet. 5:1996;989-993.
19. Trommsdorff M., Gotthardt M., Hiesberger T., Shelton J., Stockinger W., Nimpf J., Hammer R.E., Richardson J.A., Herz J. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 97:1999;689-701.
20. Tueting P., Costa E., Dwivedi Y., Guidotti A., Impagnatiello F., Manev R., Pesold C. The phenotypic characteristics of heterozygous reeler mouse. Neuroreport. 10:1999;1329-1334.