Inhibition of cocaine oxidative metabolism attenuates endotoxin potentiation of cocaine mediated hepatotoxicity

Toxicology

Volumn 179, Issue 1-2, 2002, Pages 9-19

  Labib, Ramez ^a   Turkall, Rita ^a,b   Abdel Rahman, Mohamed S ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Antioxidant enzymes; Cocaine; Dimethylaminoethyl 2,2 diphenylvalerate (SKF 525A); Endotoxin; Glutathione; Hepatotoxicity; Lipopolysaccharide; Oxidative stress

Indexed keywords

CATALASE; COCAINE; CYTOCHROME P450; ENDOTOXIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIPOPOLYSACCHARIDE; PROADIFEN;

AEROBIC METABOLISM; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DECAPITATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; LIVER; LIVER CELL; LIVER TOXICITY; MALE; METABOLIC INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICOKINETICS;

ANIMALS; BIOTRANSFORMATION; CATALASE; COCAINE; ENDOTOXINS; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEPATITIS, TOXIC; LIPOPOLYSACCHARIDES; LIVER; LIVER FUNCTION TESTS; MALE; MICE; OXIDATION-REDUCTION; PROADIFEN;

FELIS CATUS;

EID: 0037200768     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00247-0     Document Type: Article

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