Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues

Developmental Brain Research

Volumn 136, Issue 2, 2002, Pages 175-178

  Trofimova Griffin, Marina E ^a   Juchau, Mont R ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebellum; CYP26B1; Human brain development; Human prenatal cephalic tissue; P450RAI 2; Retinoic acid

Indexed keywords

CYTOCHROME; CYTOCHROME P26B1; UNCLASSIFIED DRUG;

ARTICLE; BRAIN DEVELOPMENT; BRAIN TISSUE; CEREBELLUM; CONTROLLED STUDY; EVALUATION; GENE INACTIVATION; HUMAN; HUMAN TISSUE; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

BRAIN; CELL DIFFERENTIATION; CEREBELLUM; CYTOCHROME P-450 ENZYME SYSTEM; EMBRYO; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; RNA, MESSENGER; TRETINOIN;

EID: 0037199112     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(02)00305-X     Document Type: Article

References (21)

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15. Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues
16. Patterns of CYP26 expression in human prenatal cephalic and hepatic tissues indicate an important role during early brain development
17. CDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450 (CYP26)
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19. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism
20. A novel assay for retinoic acid catabolic enzymes shows high expression in the developing hindbrain