Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1580, Issue 1, 2002, Pages 31-39

  Carubbi, Francesca ^a   Guicciardi, Maria Eugenia ^a   Concari, Mauro ^a   Loria, Paola ^a   Bertolotti, Marco ^a   Carulli, Nicola ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Bile acid; Hepatocyte; Hepatoprotection; Hepatotoxicity; Hydrophilic hydrophobic balance

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; CHOLIC ACID DERIVATIVE; DEOXYCHOLIC ACID; GAMMA GLUTAMYLTRANSFERASE; TAUROHYODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CELL STRAIN HEPG2; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPATHOGENIC EFFECT; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME RELEASE; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; PRIORITY JOURNAL;

ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; DEOXYCHOLIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HEMOLYSIS; HUMANS; TAUROCHENODEOXYCHOLIC ACID; TAURODEOXYCHOLIC ACID; TIME FACTORS; TRANSGLUTAMINASES; TUMOR CELLS, CULTURED;

EID: 0037196578     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(01)00184-6     Document Type: Article

References (40)

1. Ursodiol for the long-term treatment of PBC
2. Ursodeoxycholic acid for the treatment of primary sclerosing cholangitis: A 30-month pilot study
3. Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis: A dose-response study
4. Bile acid-induced liver toxicity: Relation to the hydrophobic-hydrophilic balance of bile acids
5. Molecular aspects of membrane stabilization by ursodeoxycholate
6. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
7. Immunomodulatory effects of ursodeoxycholic acid on immune responses
8. Hyocholic acid, a trihydroxy bile acid from pig bile
9. A study on the effect of D- and L-triiodothyronine on bile acid excretion of rats
10. Identification of bile acids in the serum and urine in cholestasis. Evidence for 6-alpha hydroxylation of bile acids in man
11. The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar-solubilizing capacities
12. The influence of bile salts structure on self association in aqueous solutions
13. Bile acids and bile salts ionization and solubility properties
14. The biological utility of the bile acid conjugation with glycine and taurine
15. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat
16. Effect of taurohyodeoxycholica acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat
17. Effect of taurohyodeoxycholic acid on biliary lipid secretion in humans
18. Dissolution of human cholesterol gallstones in bile salt-lecithin mixtures: Effect of bile salt hydrophobicity and various pHs
19. Cholesterol gallstone dissolution in bile. Dissolution kinetics of crystalline cholesterol monohydrate by conjugated chenodeoxycholate-lecithin and conjugated ursodeoxycholate-lecithin mixtures: Dissimilar phase equilibria and dissolution mechanisms
20. Regulation of biliary secretion by mdr2 P-glycoprotein in the mouse
21. Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage
22. Taurohyodeoxycholic vs ursodeoxycholic acid for gallstone dissolution: A double-blind study
23. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen
24. Hep G2 cells as a resource for metabolic studies: Lipoprotein, cholesterol and bile acids
25. Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells
26. Protein measurement with the Folin phenol reagent
27. Physicochemical properties of bile acids and their relationship to biological properties: An overview of the problem
28. Effects of bile salts on membranes
29. Effect of acute changes of bile acid pool composition on biliary lipid secretion
30. Structural changes in vesicle membrane and mixed micelles of various lipid compositions after binding of different bile salts
31. Putative mechanisms of hepatoprotective effects of ursodeoxycholate in chronic cholestatic liver diseases
32. Effects of submicellar bile salts on permeability of biological membranes to water and non-ionic solutes
33. Bile salt-induced alterations in bilayer permeability: Insights into cytoprotection and cytotoxicity
34. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes
35. Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: Potential implications for their effects in vivo
36. Sphingomyelin exhibits greatly enhanced protection compared with egg yolk phosphatidylcholine against detergent bile acids
37. Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat
38. Tauroursodeoxycholate prevents taurocholate induced cholestasis in the rat
39. Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts; in vitro studies in rat hepatocytes and human erythrocytes
40. Hepatoprotection by hydrophilic bile salts