Functional genomics of pathogenic bacteria

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 357, Issue 1417, 2002, Pages 109-116

  Moxon, E Richard ^a   Hood, D W ^a   Saunders, N J ^a   Schweda, E K H ^a   Richards, J C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bacterial virulence; Functional genomics; Haemophilus influenzae; Lipopolysaccharide; Vaccine development

Indexed keywords

BACTERIUM;

ANIMALIA; BACTERIA (MICROORGANISMS); HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; PROKARYOTA;

HAEMOPHILUS VACCINE; LIPOPOLYSACCHARIDE;

BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL INFECTION; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; GENOMICS; HAEMOPHILUS INFLUENZAE; HUMAN; IMMUNOLOGY; MICROBIOLOGY; PATHOGENICITY; PROTEIN CONFORMATION; REVIEW;

GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENOME, BACTERIAL; GENOMICS; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS VACCINES; HUMANS; LIPOPOLYSACCHARIDES; PROTEIN CONFORMATION;

EID: 0037192116     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2001.0986     Document Type: Conference Paper

References (41)

1. Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity
2. Exploring the metabolic and genetic control of gene expression on a genomic scale
3. Molecular Koch's ostulates applied to microbial pathogenicity
4. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd
5. Genetic locus for the biosynthesis of the variable portion of Neisseria gonorrhoeae lipooligo-saccaride
6. Simultaneous identification of bacterial virulence genes by negative selection
7. Tandem repeats of the tetramer 5′-CAAT-3′ present in lic2A are required for phase variation but not lipopolysaccharide biosynthesis in Haemophilus influenzae
8. Use of the complete genome sequence information of Haemophilus influenzae strain Rd to investigate lipopolysaccharide biosynthesis
9. DNA repeats identify novel virulence genes in Haemophilus influenzae
10. Sialic acid in the lipopolysaccharide of Haemophilus influenzae: Strain distribution, influence on serum resistance and structural characterization
11. Identification of a lipopolysaccharide α-2,3-sialyltransferase from Haemophilus influenzae
12. Identification of a new locus involved in expression of Haemophilus influenzae type b lipooligosaccharide
13. Molecular analysis of a locus for the biosynthesis and phase variable expression of the lacto-N-neotetraose terminal LPS structure in Neisseria meningitidis
14. Molecular modelling of three-dimensional structure and conformation flexibility of bacterial lipopolysaccharide
15. Bacterial phosphorylcholine decreases susceptibility ot the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract
16. Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms
17. Molecular analysis of a complex locus from Haemophilus influenzae involved in phase-variable lipopolysaccharide biosynthesis
18. Structure of the variable and conserved lipopolysaccharide oligosaccharide epitopes expressed by Haemophilus influenzae serotype b strain Eagan
19. Haemophilus influenzae lipopolysaccharide: The biochemistry and biology of a virulence factor
20. Challenge of investigating biologically relevant functions of virulence factors in bacterial pathogens
21. Adaptive evolution of highly mutable loci in pathogenic bacteria
22. Bacterial lipopolysaccharides: Candidate vaccines to prevent Neisseria meningitidis and Haemophilus influenzae infections
23. Simple sequence repeats in the Helicobacter pylori genome
24. Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58
25. Characterization of the phosphocholine substituted oligosaccharide in lipopolysaccharides of type b Haemophilus influenzae
26. Population genetics of pathogenic bacteria
27. Haemophilus influenzae type b meningitis in infant rats
28. Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation
29. Frequency and distribution of DNA uptake signal sequences in the Haemophilus influenzae Rd genome
30. Functional genomics of Neisseria meningitidis pathogenesis
31. Haemophilus influenzae b lipooligosaccharide induces meningeal inflammation
32. Metabolism and evolution of Haemophilus influenzae deduced from a whole genome comparison with Escherichia coli
33. A genomic perspective on protein families
34. Evaluation of phase variation of non-typeable Haemophilus influenzae lipooligosaccharide during nasopharyngeal colonization and development of otitis media in the chinchilla model
35. A new strategy for genome sequencing
36. Antigenic similarities in lipopolysaccharides of Haemophilus and Neisseria and expression of digalactoside structure also present on human cells
37. Adaptation of Haemophilus influenzae to acquired and innate humoral immunity based on phase variation of lipopolysaccharide
38. Identification of a chromosomal locus for expression of lipopolysaccharide epitopes in Haemophilus influenzae
39. The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein
40. Alteration of the cell wall of Haemophilus influenzae type b by transformation with cloned DNA: Association with attenuated virulence