QSAR study of the calcium channel antagonist activity of some recently synthesized dihydropyridine derivatives. An application of genetic algorithm for variable selection in MLR and PLS methods

Chemometrics and Intelligent Laboratory Systems

Volumn 64, Issue 1, 2002, Pages 91-99

  Hemmateenejad, Bahram ^a   Miri, Ramin ^b   Akhond, Morteza ^a   Shamsipur, Mojtaba ^c  

^a SHIRAZ UNIVERSITY   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c RAZI UNIVERSITY   (Iran)

Author keywords

Calcium channel antagonist activity; Genetic algorithms; MLR; Nifedipine analogues; PLS; QSAR; Theoretical descriptors

Indexed keywords

1,4 DIHYDROPYRIDINE; 4 (1 METHYL 5 NITRO 2 IMIDAZOLYL)DIHYDROPYRIDINE; CALCIUM CHANNEL BLOCKING AGENT; CARBON; DIHYDROPYRIDINE DERIVATIVE; DRUG RECEPTOR; ESTER; NIFEDIPINE DERIVATIVE; NITROIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION COEFFICIENT; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ERROR; GENETIC ALGORITHM; HYDROPHOBICITY; INTERMETHOD COMPARISON; MODEL; MULTIPLE LINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; THEORY;

EID: 0037191112     PISSN: 01697439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-7439(02)00068-0     Document Type: Article

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