Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells

Cancer Letters

Volumn 177, Issue 2, 2002, Pages 155-161

  Sasahara, Yasuyoshi ^a,b   Mutoh, Michihiro ^a,b   Takahashi, Mami ^a   Fukuda, Kazunori ^c   Tanaka, Naomi ^b   Sugimura, Takashi ^a   Wakabayashi, Keiji ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Butyrate; Colon cancer; Histone acetylation; Inducible nitric oxide synthase; Reporter gene assay

Indexed keywords

BUTYRIC ACID; CYCLOOXYGENASE 2; HISTONE; HISTONE DEACETYLASE INHIBITOR; NITRIC OXIDE SYNTHASE; TRICHOSTATIN A;

ACETYLATION; ARTICLE; CANCER CELL; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPRESSION; GENE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE;

BUTYRATES; CELL DIVISION; COLONIC NEOPLASMS; HUMANS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0037187448     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00778-9     Document Type: Article

References (27)

1. NSAIDs as cancer preventive agents
2. Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor
3. Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor
4. Frequent nitric oxide synthase-2 expression in human colon adenomas: Implication for tumor angiogenesis and colon cancer progression
5. Short-chain fatty acids in human large intestine, portal, hepatic and venous blood
6. Short-chain fatty acids in the human colon
7. Role of short-chain fatty acids in the prevention of colorectal cancer
8. Sodium butyrate inhibits histone deacetylation in cultured cells
9. Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation
10. Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure
11. Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1
12. One-dimensional gel analysis of histone synthesis
13. Histone hyperacetylation is accompanied by changes in DNA topology in vivo
14. Neuronal apoptosis induced by histone deacetylase inhibitors
15. Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells
16. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells
17. Sodium butyrate modulates p53 and Bcl-2 expression in human retinoblastoma cell lines
18. The luminal short-chain fatty acid butylate modulates NF-kappaB activity in a human colonic epithelial cell line
19. The inhibitory action of butyrate on lipopolysaccharide-induced nitric oxide production in RAW 264.7 murine macrophage cells
20. Sodium butyrate inhibits c-myc splicing and interferes with signal transduction in ovarian carcinoma cells
21. Potentiation of cytokine induced iNOS expression in the human intestinal epithelial cell line, DLD-1, by cyclic AMP
22. Rectal irrigation with short-chain fatty acids for distal ulcerative colitis. Preliminary report
23. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis
24. Treatment of refractory ulcerative proctosigmoiditis with butyrate enemas
25. Short-chain fatty acids topical treatment in distal ulcerative colitis
26. Treatment of refractory distal ulcerative colitis with short-chain fatty acid enemas
27. Induction of tissue transglutaminase expression by propionate and n-butyrate in colon cancer cell lines