Aging and neuronal plasticity: Lessons from a model

Autonomic Neuroscience: Basic and Clinical

Volumn 96, Issue 1, 2002, Pages 25-32

  Crutcher, Keith A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Hippocampus; Nerve growth factor (NGF); Sprouting; Substrate; Sympathetic

Indexed keywords

AGING; BRAIN TISSUE; CONFERENCE PAPER; HIPPOCAMPUS; INFORMATION RETRIEVAL; NERVE CELL; NERVE FIBER GROWTH; NERVE SPROUTING; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; SYMPATHETIC NERVE CELL; TARGET ORGAN;

AGING; ANIMALS; DENERVATION; DOWN-REGULATION; GROWTH CONES; HIPPOCAMPUS; HUMANS; MODELS, NEUROLOGICAL; NERVE GROWTH FACTOR; NEURONAL PLASTICITY; SEPTAL NUCLEI; SUPERIOR CERVICAL GANGLION; SYMPATHETIC FIBERS, POSTGANGLIONIC;

EID: 0037186482     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1566-0702(01)00373-3     Document Type: Conference Paper

References (55)

1. Involvement of nerve growth factor and its receptor in the regulation of the cholinergic function in aged rats
2. Persistence of sympathetic ingrowth fibers in aged rat hippocampus
3. Diminished viability, growth, and behavioral efficacy of fetal dopamine neuron grafts in aging rats with long-term dopamine depletion: An argument for neurotrophic supplementation
4. Neurotrophic activity in the adult rat hippocampal formation: Regional distribution and increase after septal lesion
5. The localization of nerve growth factor-like immunoreactivity in the adult rat basal forebrain and hippocampal formation
6. Synaptic plasticity, neurotrophic factors, and transplantation in the aged brain
7. Plasticity in adult and ageing sympathetic neurons
8. Histochemical studies of sympathetic sprouting: Fluorescence morphology of noradrenergic axons
9. Sympathetic sprouting in the central nervous system: A model for studies of axonal growth in the mature mammalian brain
10. Age-related decrease in sympathetic sprouting is primarily due to decreased target receptivity: Implications for understanding brain aging
11. In vitro evidence for two distinct hippocampal growth factors: Basis of neuronal plasticity?
12. Target regulation of sympathetic sprouting in the rat hippocampal formation
13. Nonregenerative axonal growth within the mature mammalian brain: Ultrastructural identification of sympathohippocampal sprouts
14. Sympathetic noradrenergic sprouting in response to central cholinergic denervation; a histochemical study of neuronal sprouting in the rat hippocampal formation
15. Evidence that endogenous β nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats
16. Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF
17. Endogenous NGF and nerve impulses regulate the collateral sprouting of sensory axons in the skin of the adult rat
18. Time course of the elevation of nerve growth factor (NGF) content in the hippocampus and septum following lesions of the septohippocampal pathway in rats
19. Axonal regeneration from transplanted sympathetic ganglia is not impaired by age
20. Influence of target tissues on their innervation in old age: A transplantation study
21. Reduced laminin immunoreactivity in the blood vessel wall of ageing rats correlates with reduced innervation in vivo and following transplantation
22. Extracellular matrix molecules influence innervation density in rat cerebral blood vessels
23. Responsiveness of sympathetic and sensory irideal nerves to NGF treatment in young and aged rats
24. Nerve growth factor levels and choline acetyltransferase activity in the brain of aged rats with spatial memory impairments
25. Uninjured aged sympathetic neurons sprout in response to exogenous NGF in vivo
26. Intracerebral NGF infusion induces hyperinnervation of cerebral blood vessels
27. Nerve growth factor-induced sprouting of mature, uninjured sympathetic axons
28. Sympathetic axons invade the brains of mice overexpressing nerve growth factor
29. Sensory nociceptive axons invade the cerebellum of transgenic mice overexpressing nerve growth factor
30. Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content
31. Neurotrophin receptor and tyrosine hydroxylase gene expression in aged sympathetic neurons
32. Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain
33. Nerve growth factor protein level increases in the adult rat hippocampus after a specific cholinergic lesion
34. Developmental appearance of nerve growth factor in the rat brain: Significant deficits in the aged forebrain
35. Neurotropic effects of the nerve growth factor in chick embryos and in neonatal rodents
36. Sympathetic nerve fibers ingrowth in the central nervous system of neonatal rodent upon intracerebral NGF injections
37. Life and death of neurons in the aging brain
38. Induction of a neurite-promoting factor in rat brain following injury or deafferentation
39. Sympathetic neurite growth on central nervous system sections is region-specific and unaltered by aging
40. Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth
41. Decrease in adrenergic axon sprouting in the senescent rat
42. Increased NGF-like activity in young but not aged rat hippocampus after septal lesions
43. Enhanced sympathetic neurite outgrowth on rat hippocampal tissue sections following septal lesions
44. Effects of nerve growth factor and heart cell conditioned medium on neurite regeneration of aged sympathetic neurons in culture
45. Loss of nerve growth factor receptors in sympathetic ganglia from aged mice
46. Fimbria-fornix lesion increases nerve growth factor content in adult rat septum and hippocampus
47. Cholinergic but not monoaminergic denervation increases nerve growth factor content in the adult rat hippocampus and cerebral cortex
48. Neuronotrophic factors for mammalian brain neurons: Injury induction in neonatal, adult and aged rat brain
49. Increased beta-nerve growth factor messenger RNA and protein levels in neonatal rat hippocampus following specific cholinergic lesions
50. Deafferentation-induced increases in hippocampal insulin-like growth factor-1 messenger RNA expression are severely attenuated in middle aged and aged rats
51. Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation