Age-related sympathetic ganglionic neuropathology: Human pathology and animal models

Autonomic Neuroscience: Basic and Clinical

Volumn 96, Issue 1, 2002, Pages 63-72

  Schmidt, Robert E ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Animal model; Human pathology; Sympathetic ganglionic neuropathology

Indexed keywords

DOPAMINE BETA MONOOXYGENASE; NERVE GROWTH FACTOR RECEPTOR; NEUROPEPTIDE Y; PROTEIN P75; TYROSINE 3 MONOOXYGENASE;

ADRENERGIC SYSTEM; AGE; AGING; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM; BODY DISTRIBUTION; CONFERENCE PAPER; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE MODEL; DYSTROPHY; EXPERIMENTAL ANIMAL; HUMAN; IMMUNOPHENOTYPING; IMMUNOREACTIVITY; NERVE CELL PLASTICITY; NERVE FIBER; NERVOUS SYSTEM; NEUROAXONAL DYSTROPHY; NEUROFILAMENT; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PHOSPHORYLATION; PRIORITY JOURNAL; SEX DIFFERENCE; SUPERIOR CERVICAL GANGLION; SYMPATHETIC GANGLION; SYMPATHETIC NERVE CELL; SYNAPSE; SYSTEMIC CIRCULATION;

AGING; ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; BIOLOGICAL MARKERS; DIABETIC NEUROPATHIES; DISEASE MODELS, ANIMAL; FEMALE; GANGLIA, SYMPATHETIC; HUMANS; MALE; NERVE DEGENERATION; NEURONAL PLASTICITY; PRESYNAPTIC TERMINALS; SEX FACTORS;

EID: 0037186470     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1566-0702(01)00372-1     Document Type: Conference Paper

References (87)

1. Neurodegeneration in sweat glands and skin of aged rats
2. Plasticity of substance P in mature and aged sympathetic neurons in culture
3. Nerve growth factor enhances the dendritic arborization of sympathetic ganglion cells undergoing atrophy in aged rats
4. Target-specific differences in the dendritic morphology and neuropeptide content of neurons in the rat SCG during development and age
5. A quantitative study of the effects of age on the noradrenergic innervation of Auerbach's plexus in the rat
6. Innervation of the rat gastrointestinal sphincters: Changes during development and ageing
7. Aging and the autonomic nervous system
8. Cardiovascular, sympathetic and adrenal cortical responsiveness of aged Fischer-344 rats to stress
9. Synapse replacement in the nervous system of adult vertebrates
10. Ageing in the autonomic nervous system: A result of nerve target interactions, a review
11. Plasticity in adult and ageing sympathetic neurons
12. Transplanted sweat glands from mature and aged donors determine cholinergic phenotype an altered density of host sympathetic nerves
13. Age-related decrease in sympathetic sprouting is primarily due to decreased target receptivity: Implications for understanding brain aging
14. Over-expression of NGF in skin causes formation of novel sympathetic projections to trkA-positive sensory neurons
15. Age-related changes in the morphology of preganglionic neurons projecting to rat hypogastric ganglion
16. Age-related changes in the morphology of preganglionic neurons projecting to the paracervical ganglion of nulliparous and multiparous rats
17. Reconstruction of motor, sensory and autonomic neurons based on morphometric study of sampled levels
18. Cold-induced thermoregulation and biological aging
19. Alterations in mystacial pad innervation in the aged rat
20. Collateral sprouting and responsiveness to nerve growth factor of ageing neurons
21. NGF can induce a 'young' pattern of innervation in transplanted old cerebral blood vessels
22. Can the neurotrophic hypothesis explain degeneration and loss of plasticity in mature and ageing autonomic nerves
23. Influence of target tissues on their innervation in old age: A transplantation study
24. Lack of correlation between NGF levels and altered nerve fibre density in peripheral tissues of aging rats
25. Sympathetic nerves in adult rats regenerate normally and restore pilomotor function during an anti-NGF treatment that prevents their collateral sprouting
26. Effects of aging at the adrenergic cardiac neuroeffector junction
27. Changes in expression of a synaptic vesicle antigen in aging sympathetic neurons
28. Fine-structural and degenerative features in adult and aged human sympathetic ganglion cells
29. Age related neuropathologic changes in human sympathetic ganglia
30. The sympathetic neuron, a model of neuronal aging
31. Age-related changes of sympathetic outflow to muscles in humans
32. Age-related changes on enkephalinergic innervation of human sympathetic neurons
33. Neuroaxonal dystrophy: Its natural history and related disorders
34. Integration in autonomic ganglia
35. Alterations in target innervation and collateral sprouting in the aging sympathetic nervous system
36. Functional recovery and collateral neuronal sprouting examined in young and aged rats following a partial neural lesion
37. Decreased neurofilament gene expression is an index of selective axonal hypotrophy in ageing
38. NGF expression in the aged rat pineal gland does not correlate with loss of sympathetic axonal branches and varicosities
39. Histological variation in autonomic ganglia and ganglion cells associated with age and disease
40. Nerve growth factor induces volume increase and enhances tyrosine hydroxylase synthesis in chemically axotomized sympathetic ganglia of newborn rats
41. Aging and the autonomic nervous system
42. Proteolysis is a critical step in the physiological stop pathway: Mechanisms involved in the blockade of axonal regeneration by mammalian astrocytes
43. The effect of aging on the autonomic nervous system
44. Splanchnic preganglionic neurons in man: I. Morphometry of preganglionic cytons
45. Sympathetic-adrenal medullary and cardiovascular responses to acute cold stress in adult and aged rats
46. Age-related changes in colonic function in rats
47. Expression of NGF receptor and gap-43 mRNA in DRG neurons during collateral sprouting and regeneration of dorsal cutaneous nerves
48. An increase in the expression of neuropeptidergic vasodilator, but not vasoconstrictor, cerebrovascular nerves in aging rats
49. Effect of age on collateral reinnervation of sweat glands in the mouse
50. Sympathetic neural reactivity to stress does not increase with age in healthy humans
51. Transganglionic response of GAP-43 in the gracile nucleus to sciatic nerve injury in young and aged rats
52. The effect of aging on the histochemically demonstrable catecholamines in the hypogastric (major pelvic) ganglion of the rat
53. Indices of neurotransmitter synthesis and release in aging sympathetic nervous system
54. Nerve terminal remodeling visualized in living mice by repeated examination of the same neurons
55. Changes in the activity and amounts of enzymes synthesizing catecholamines and acetylcholine in brain, adrenal medulla, and sympathetic ganglia of aged rat and mouse
56. Sympathetic nervous system and aging in man
57. Sympathetic neuron numbers in ganglia of young and aged rats
58. Morphological evidence for the maintenance of the cervical sympathetic system in aged rats
59. Quantitative analysis of the cervical sympathetic trunk in young adult and aged rats
60. Glyoxylic acid fluorescence and ultrastructural studies of neurones in the coeliac-superior mesenteric ganglia of the aged rat
61. Changes in neuronal structure and cell populations with ageing
62. Decrease in adrenergic axon sprouting in the senescent rat
63. Neuroaxonal dystrophy in aging rodent and human sympathetic autonomic ganglia: Synaptic pathology as a common theme in neuropathology
64. Neuropathology of human sympathetic autonomic ganglia
65. Synaptic dysplasia in sympathetic autonomic ganglia
66. Axonal dystrophy in experimental diabetic autonomic neuropathy
67. Neuroaxonal dystrophy in the autonomic ganglia of aged rats
68. Differential susceptibility of prevertebral and paravertebral sympathetic ganglia to experimental injury
69. Ultrastructural and immunohistochemical characterization of autonomic neuropathy in genetically diabetic Chinese hamsters
70. Neuroaxonal dystrophy in aging human sympathetic ganglia
71. Immunohistochemical characterization of NPY and substance P containing nerve terminals in aged and diabetic human sympathetic ganglia
72. Effect of diabetes and aging on human sympathetic autonomic ganglia
73. Pathologic alterations in pre-and postsynaptic elements in aged mouse sympathetic ganglia
74. Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia
75. Insulin-like growth factor I reverses experimental diabetic autonomic neuropathy
76. Effect of NGF and neurotrophin-3 treatment on experimental diabetic autonomic neuropathy
77. Fine structure of presynaptic axonal terminals in sympathetic autonomic ganglia of aging and diabetic human subjects
78. Increased NGF-like activity in young but not aged rat hippocampus after septal lesions
79. Regulation of rat sympathetic nerve density by target tissues and NGF in maturity and old age
80. Deprenyl partially restores the age-related loss of sympathetic noradrenergic innervation in the spleens of F344 rats
81. Mitogen-activated protein kinases as glucose transducers for diabetic complications
82. Loss of nerve growth factor receptors in sympathetic ganglia from aged mice
83. Age-dependent changes of the sympathetic innervation of the rat kidney
84. Sympathetic and sensory innervation of the urinary tract in young adult and aged rats: A semi-quantitative histochemical and immunolocalisation study
85. Decrease in synapsin I staining in the hypogastric ganglion of aged rats
86. The hypogastric and thirteenth thoracic ganglia of the rat: Effects of age on the neurons and their extracellular environment
87. Age-related changes in the sympathetic plasticity of rat superior cervical ganglia