Receptor-dependent regulation of the CYP3A4 gene

Toxicology

Volumn 181-182, Issue , 2002, Pages 199-202

  Gibson, G Gordon ^a   El Sankary, Wafaa ^a   Plant, Nick J ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

estradiol; CYP3A4; Cytochrome P450; Dexamethasone; Glucocorticoid receptor; Hydrocortisone; Inducer ranking; Pregnane X receptor; Promoter mutations; Promoter reporter gene constructs; Receptor regulation; Rifampicin; Transcriptional activation

Indexed keywords

ADENINE; CARBAMAZEPINE; CARRIER PROTEIN; CLOTRIMAZOLE; CYPROTERONE ACETATE; CYTOCHROME P450 3A4; CYTOSINE; DEXAMETHASONE; ESTRADIOL; GUANINE; HYDROCORTISONE; METYRAPONE; MEVINOLIN; NUCLEAR FACTOR; PHENOBARBITAL; PHENYTOIN; PRAVASTATIN; RECEPTOR; RIFAMPICIN; SIMVASTATIN; SPIRONOLACTONE; STEROID; SULFINPYRAZONE; TERFENADINE; THYMINE; TROGLITAZONE; XENOBIOTIC AGENT;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESTROGEN RESPONSIVE ELEMENT; GENE CONSTRUCT; GENE CONTROL; GENE INDUCTION; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSACTIVATION;

CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ESTRADIOL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HUMANS; HYDROCORTISONE; MUTATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GLUCOCORTICOID; RECEPTORS, STEROID; TRANSFECTION;

STAPHYLOCOCCUS PHAGE 187;

EID: 0037184876     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00281-0     Document Type: Article

References (5)

1. El-Sankary W., Plant N.J., Gibson G.G. Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors. Drug Metab. Dispn. 28:2000;493-496.
2. Guengerich F.P. Cytochrome P450 3A4: regulation and role in metabolism. Ann. Rev. Pharmacol. Toxicol. 39:1999;1-17.
3. Honkakoski P., Negishi M. Regulation of cytochrome P450 genes by nuclear receptors. Biochem. J. 347:1999;321-337.
4. Plant N.J., Ogg M., Crowder M., Gibson G.G. Control and statistical analysis of in vitro reporter gene assays. Anal. Biochem. 278:2000;170-174.
5. Tokui T., Nakai D., Nakagomi R., Yawo H., Abe T., Sugiyama Y. Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2. Pharm. Res. 16:1999;904-908.