Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays

Toxicology

Volumn 181-182, Issue , 2002, Pages 261-264

  Guengerich, F Peter ^a   Wheeler, James B ^a   Chun, Young Jin ^a   Kim, Donghak ^a   Shimada, Tsutomu ^b   Aryal, Pramod ^b   Oda, Yoshimitsu ^b   Gillam, Elizabeth M J ^c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cytochrome P450; Expression; Genotoxicity; Glutathione transferase; Heterologous; Toxicity assays

Indexed keywords

ALKANE; AMINE; CYTOCHROME P450; DIHALOALKANE; DIHALOMETHANE; GLUTATHIONE TRANSFERASE; METHANE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM; CATALYSIS; CONTROLLED STUDY; DETOXIFICATION; ENZYME PURIFICATION; ESCHERICHIA COLI; HETEROLOGOUS EXPRESSION; HUMAN; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM; TOXICITY; TOXICOLOGY;

ANTICARCINOGENIC AGENTS; BACTERIA; CYTOCHROME P-450 ENZYME SYSTEM; DNA; DNA, COMPLEMENTARY; ESCHERICHIA COLI; GLUTATHIONE TRANSFERASE; HUMANS; MUTAGENS; SALMONELLA TYPHIMURIUM; TOXICOLOGY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0037184782     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00293-7     Document Type: Article

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