Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells

Transplantation

Volumn 74, Issue 8, 2002, Pages 1159-1166

  Bühler, Leo ^a   Kurilla Mahon, Barbara ^a   Chang, Qing ^a   Abraham, Sonny ^a   Alwayn, Ian P J ^a   Appel III, James Z ^a   Newman, Dawne ^a   Awwad, Michel ^a   White Scharf, Mary E ^a   Sackstein, Roberto ^a   Sachs, David H ^a   Cooper, David K C ^a   Down, Julian D ^a  

^a BioTransplant Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DIMETHYL SULFOXIDE; HETASTARCH; METHYLCELLULOSE; MYCOPHENOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BABOON; BONE MARROW BIOPSY; CELL MATURATION; CHIMERA; COBBLESTONE AREA FORMING CELL; COLONY FORMATION; COLONY FORMING UNIT; CONTROLLED STUDY; CRYOPRESERVATION; DOSE RESPONSE; FREEZING; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKAPHERESIS; MALE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; THAWING;

EID: 0037184328     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200210270-00018     Document Type: Article

References (35)

1. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989; 169: 493.
2. Sharabi Y, Aksentijevich I, Sundt TM III, et al. Specific tolerance induction across a xenogeneic barrier, production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen. J Exp Med 1990; 172: 195.
3. Huang CA, Fuchimoto Y, Scheier-Dolberg R, et al. Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a largeanimal model. J Clin Invest 2000; 105: 173.
4. Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59: 256.
5. Bartholomew AM, Cosimi AB, Sachs DH, et al. A study of tolerance in a concordant xenograft model. Transplant Proc 1995; 29: 923.
6. Spitzer TR, Delmonico F, Tolkoff-Rubin N, et al. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: The induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation 1999; 68: 480.
7. Buhler L, Spitzer T, Sykes M, et al. Induction of allograft tolerance and antitumor effects through mixed lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Am J Trans 2001; 1 (suppl 1): 298.
8. Sykes M, Preffer F, McAfee S, et al. Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Lancet 1999; 353: 1725.
9. Spitzer TR, McAfee S, Sackstein R, et al. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol Blood Marrow Transplant 2000; 6: 309.
10. McSweeney PA, Niederwieser D, Shizuru JA, et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: Replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood 2001; 97: 3390.
11. Childs R, Chernoff A, Contentin N, et al. Regression of metastatic renalcell carcinoma after nonmyeloablative allogeneic peripheral-bloodstem-cell transplantation. N Engl J Med 2000; 343: 750.
12. Kozlowski T, Shimizu A, Lambrigts D, et al. Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption. Transplantation 1999; 67: 18.
13. Bühler L, Awwad M, Treter S, et al. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. Transplantation (In press).
14. Van Leeuwen L, Guiffre AK, Sewell WA, et al. Administration of mycophenolate mofetil in a murine model of acute graft-versus-host disease after bone marrow transplantation. Transplantation 1997; 64: 1097.
15. Storb R, Yu C, Wagner JL, et al. Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before pharmacological immunosuppression after marrow transplantation. Blood 1997; 89: 3048.
16. Yu C, Seidel K, Nash RA, et al. Synergism between mycophenolate mofetil and cyclosporine in preventing graft-versus-host disease among lethally irradiated dogs given DLA-nonidentical unrelated marrow grafts. Blood 1998; 91: 2581.
17. Bornhauser M, Schuler U, Porksen G, et al. Mycophenolate mofetil and cyclosporine as graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation. Transplantation 1999; 67: 499.
18. Sachs DH, Leight G, Cone J, et al. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 1976; 22: 559.
19. Cooper DKC, Ye Y, Niekrasz M. Heart transplantation in primates. In: Cramer DV, Podesta L, Makowka L, eds. Handbook of Animal Models in Transplantation Research. Boca Raton, Florida, CRC Press 1994, p 173.
20. Hawley RJ, Abraham S, Akiyoshi DE, et al. Xenogeneic bone marrow transplantation: I. Cloning, expression, and species specificity of porcine IL-3 and granulocyte-macrophage colony-stimulating factor. Xenotransplantation 1997; 4: 103.
21. Giovino MA, Hawley RJ, Dickerson MW, et al. Porcine-specific growth factors enhance bone marrow engraftment in an in vitro primate microenvironment. Xenotransplantation 1997; 4: 112.
22. Nash K, Chang Q, Watts A, et al. Peripheral blood progenitor cell mobilization and leukapheresis in pigs. Lab Anim Sci 1999; 49: 645.
23. Stiff PJ. Simplified bone marrow cryopreservation using dimethyl sulfoxide and hydroxyethyl starch as cryoprotectants. In: Gee AP, ed. Bone marrow processing and purging. Boca Raton, Florida, CRC Press 1991, p 341.
24. Ploemacher RE, van der Sluijs JP, Voerman JSA, et al. An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cell in the mouse. Blood 1989; 74: 2755.
25. Breems DA, Blokland EAW, Neben S, et al. Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay. Leukemia 1994; 8: 1095.
26. Ploemacher RE, van der Sluijs JP, van Beurden CAJ, et al. Use of limitingdilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse. Blood 1991; 78: 2527.
27. Beaujean F, Bourhis JH, Bayle C, et al. Successful cryopreservation of purified autologous CD34+ cells: Influence of freezing parameters on cell recovery and engraftment, Bone Marrow Transplant 1998; 11: 1091.
28. Cabezudo E, Dalmases C, Ruz M, et al. Leukapheresis components may be cryopreserved at high cell concentrations without additional loss of HPC function. Transfusion 2000; 40: 1223.
29. Humpe A, Riggert J, Wolf C, et al. Successful transplantation and engraftment of peripheral blood stem cells after cryopreservation, positive and negative purging procedures, and a second cryopreservation cycle. Ann Hematol 2001; 80: 109.
30. Allison AC, Eugui EM. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 1993; 136: 5.
31. European Mycophenolate Mofetil Cooperative Study Group. Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection: European Mycophenolate Mofetil Cooperative Study Group. Lancet 1995; 345: 1321.
32. Gray DW. Mycophenolate mofetil for transplantation: New drug, old problems? Lancet 1995; 346: 390.
33. Lambrigts D, Van Calster P, Xu Y, et al. Pharmacologic immunosuppressive therapy and extracorporeal immunoadsorption in the suppression of antialphaGal antibody in the baboon. Xenotransplantation 1998; 5: 274.
34. Pally C, Tanner M, Rizvi H, et al. Tolerability profile of sodium mycophenolate (ERL080) and mycophenolate mofetil with and without cyclosporine (Neoral) in the rat. Toxicology 2001; 157: 207.
35. Down JD, Boudewijn A, Dillingh JH, et al. Relationships between ablation of distinct haematopoietic cell subsets and the development of donor bone marrow engraftment following recipient pretreatment with different alkylating drugs. Br J Cancer 1994; 70: 611.