Somatic cell mutation in pediatric patients undergoing allogeneic bone marrow transplantation

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 517, Issue 1-2, 2002, Pages 21-28

  Hamahata, Keigo ^a   Kubota, Masaru ^b   Usami, Ikuya ^b   Lin, Ying Wei ^a   Shimizu, Ken ^c   Morimoto, Akira ^d   Nakahata, Tatsutoshi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

^c TENRI HOSPITAL   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Bone marrow transplantation; Children; HPRT; Malignancy; Mutant frequency; T cell antigen receptor

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LYMPHOCYTE ANTIBODY; MELPHALAN; T LYMPHOCYTE RECEPTOR; THYMOCYTE ANTIBODY;

ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ALLOGENIC BONE MARROW TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; CHILD; CHIMERA; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CONDITIONING; CONTROLLED STUDY; DONOR; FEMALE; GENDER; GENE LOCUS; GENE MUTATION; GENOTOXICITY; HISTOCOMPATIBILITY; HUMAN; HYPERIMMUNOGLOBULINEMIA M; MALE; MUTATION RATE; PRIORITY JOURNAL; RECIPIENT; SOMATIC CELL; T CELL LYMPHOMA; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; AGE FACTORS; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; CLONING, MOLECULAR; FEMALE; FLOW CYTOMETRY; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INFANT; MALE; MIDDLE AGED; MUTATION; RECEPTORS, ANTIGEN, T-CELL; TRANSPLANTATION, HOMOLOGOUS;

EID: 0037182136     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(02)00023-2     Document Type: Article

References (31)

1. National registry of hematopoietic stem cell transplantation in children, 1998
2. Late effects after allogeneic bone marrow transplantation
3. Solid cancers after bone marrow transplantation
4. Malignancies after hematopoietic stem cell transplantation: Many questions, some answers
5. New malignant diseases after allogeneic marrow transplantation for childhood leukemia
6. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo
7. Factors influencing mutation at the Hprt locus in T-lymphocytes: Women treated for breast cancer
8. Multiple biological markers in germ cell tumor patients treated with platinum-based chemotherapy
9. Analysis of Hprt gene mutation following anti-cancer treatment in pediatric patients with acute leukemia
10. Frequencies of Hprt mutants and micronuclei in lymphocytes of cancer patients under chemotherapy: A prospective study
11. Somatic mutations at T-cell antigen receptor and glycophorin A loci in pediatric leukemia patients following chemotherapy: Comparison with HPRT locus mutation
12. Glycophorin A mutations and risk of secondary leukaemia in patients treated for childhood acute lymphoblastic leukaemia
13. Cancer chemotherapy and somatic cell mutation
14. T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood
15. Measurement of in vivo mutations in human lymphocytes
16. Simultaneous genotypic and immunophenotypic analysis of interphase cells using dual-color fluorescence: A demonstration of lineage involvement in polycythemia vera
17. Rapid HLA-class I DNA typing using microtiter plate-reverse hybridization assay (MRHA) by simple thermoregulation: High-resolution subtyping of the HLA-A2 and -B40 antigen groups
18. + T-cells
19. Evaluation of mutant frequencies at the Hprt and the T-cell receptor loci in pediatric cancer patients before treatment
20. Second neoplasms after acute lymphoblastic leukemia in childhood
21. Forty-year experience with second malignancies after treatment of childhood cancer: Analysis of outcome following the development of the second malignancy
22. The incidence of recurrence of leukemia in donor cells after allogeneic bone marrow transplantation
23. Recurrence of Ph1-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia
24. Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients III: Measurement of mutant frequency to 6-thioguanine resistance
25. In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients
26. Biomarkers in long survivors of pediatric acute lymphoblastic leukemia patients: Late effects of cancer chemotherapy
27. Emergence of genetic instability in children treated for leukemia
28. Determination of Hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: Statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age
29. Molecular aspects of chemical mutagenesis in L5178Y/tk+/- mouse lymphoma cells
30. Azathioprine associated T-cell mutations in insulin-dependent diabetes mellitus
31. Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells