Basal transcription activity of the dyskeratosis congenita gene is mediated by Sp1 and Sp3 and a patient mutation in a Sp1 binding site is associated with decreased promoter activity

Gene

Volumn 293, Issue 1-2, 2002, Pages 9-19

  Salowsky, Rüdiger ^a   Heiss, Nina S ^a   Benner, Axel ^a   Wittig, Rainer ^a   Poustka, Annemarie ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Core promoter; DKC1 gene; Promoter analyses; Promoter mutation; Sp1 Sp3 transcription factors

Indexed keywords

PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; TRANSCRIPTION FACTOR SP3;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DYSKERATOSIS CONGENITA; EMBRYO; FEMALE; GC RICH SEQUENCE; GENE ACTIVITY; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN INTERACTION; REPORTER GENE; TRANSCRIPTION INITIATION;

5' FLANKING REGION; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; GC RICH SEQUENCE; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0037178265     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(02)00725-4     Document Type: Article

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