HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease

Neurology

Volumn 58, Issue 6, 2002, Pages 973-975

  Zareparsi, S ^a,e   James, D M ^a   Kaye, J A ^a,b   Bird, T D ^c,d   Schellenberg, G D ^c,d   Payami, H ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; HLA A2 ANTIGEN;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; FEMALE; GENE FUNCTION; GENE LOCUS; GENETIC LINKAGE; HETEROZYGOSITY; HLA SYSTEM; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; RECESSIVE INHERITANCE;

EID: 0037177088     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.58.6.973     Document Type: Article

References (10)

1. Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
2. HLA-A2, or a closely linked gene, confers susceptibility to early onset sporadic Alzheimer's disease in men
3. Human leukocyte antigen-A2 increases risk of Alzheimer's disease but does not affect age of onset in a Scottish population
4. Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease
5. Association of the HLA-A2 allele with an earlier age of onset of Alzheimer's disease
6. HLA A2 allele is associated with age at onset of Alzheimer's disease
7. Complete genomic screen in late-onset familial Alzheimer's disease
8. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups
9. Neuroimmune mechanisms in Alzheimer disease pathogenesis
10. Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs