The insertion of an anti-MHC I ScFv into the N-terminus of an ecotropic MLV glycoprotein does not alter its fusiogenic potential on murine cells

Virus Research

Volumn 83, Issue 1-2, 2002, Pages 57-69

  Karavanas, Georgios ^a,b   Marin, Mariana ^a   Bachrach, Estanislao ^a   Papavassiliou, Athanasios G ^b   Piechaczyk, Marc ^a  

^a CNRS   (France)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

Cell targeting; Envelope glycoprotein; Fusion; Retrovirus; Viral receptor

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; VIRUS GLYCOPROTEIN; VIRUS RECEPTOR;

AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL CULTURE; CONTROLLED STUDY; ECOTROPIC VIRUS; MEMBRANE BINDING; MEMBRANE FUSION; MURINE LEUKEMIA VIRUS; NONHUMAN; PLANT GROWTH; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR BINDING; TARGET CELL; VIRUS ENVELOPE; VIRUS EXPRESSION; VIRUS TITRATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; GLYCOPROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA VIRUS, MURINE; MEMBRANE FUSION; MICE; MUTAGENESIS, INSERTIONAL; RATS; TUMOR CELLS, CULTURED; VIRAL ENVELOPE PROTEINS;

INSERTION SEQUENCES; MURINAE; MURINE LEUKEMIA VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0037177005     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(01)00419-1     Document Type: Article

References (28)

1. Efficient cell infection by Moloney murine leukemia virus-derived particles requires minimal amounts of envelope glycoprotein
2. Functional dissection of the Moloney murine leukemia virus envelope protein gp70
3. Targeting retroviral vectors to CD34-expressing cells: Binding to CD34 does not catalyze virus-cell fusion
4. Immunodeficiency viruses. Spoilt for choice of co-receptors
5. High titer retroviral packaging systems which produce human complement-resistant retroviral vectors
6. Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers
7. Identification of a receptor-binding pocket on the envelope protein of friend murine leukemia virus
8. Influence of transmembrane domains on the fusiogenic ability of man and murine leukemia retroviruses envelopes
9. Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 A resolution
10. Retrovirus envelope glycoproteins
11. Functional analysis of the cytoplasmic tail of Moloney murine leukemia virus envelope protein
12. Cell targeting by murine retroviral vectors
13. The hypervariable domain of the murine leukemia virus surface protein tolerates large insertions and deletions, enabling development of a retroviral particle display system
14. Definition of an amino-terminal domain of the human T-cell leukemia virus type 1 envelope surface unit that extends the fusiogenic range of an ecotropic murine leukemia virus
15. A Pro-rich motif downstream of the receptor binding domain modulates conformation and fusiogenicity of murine retroviral envelopes
16. Retargeting gene delivery using surface-engineered retroviral particles
17. Towards efficient cell targeting by recombinant retroviruses
18. Targeted infection of human cells via major histocompatibility complex class I molecules by Moloney murine leukemia virus-derived viruses displaying single-chain antibody fragment-envelope fusion proteins
19. Co-receptors for HIV-1 entry
20. pH-independent murine leukemia virus ecotropic envelope-mediated cell fusion: Implications for the role of the R peptide and p12E TM in viral entry
21. The amphotropic and ecotropic murine leukemia virus envelope TM subunits are equivalent mediators of direct membrane fusion: Implications for the role of the ecotropic envelope and receptor in syncytium formation and viral entry
22. Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein
23. Evidence for cooperation between murine leukemia virus Env molecules in mixed oligomers
24. A versatile and potentially general approach to the targeting of specific cell types by retroviruses: Application to the infection of human cells by means of major histocompatibility complex class I and class II antigens by mouse ecotropic murine leukemia virus-derived viruses
25. Modifying the host-range properties of retroviral vectors
26. Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex
27. Suppression of a fusion defect by second site mutations in the ecotropic murine leukemia virus surface protein
28. Functional interactions between monomers of the retroviral envelope protein complex