The hypervariable domain of the murine leukemia virus surface protein tolerates large insertions and deletions, enabling development of a retroviral particle display system

Journal of Virology

Volumn 73, Issue 3, 1999, Pages 1802-1808

  Kayman, Samuel C ^a   Park, Han ^a   Saxon, Maya ^a   Pinter, Abraham ^a  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DISULFIDE; EPITOPE; MONOCLONAL ANTIBODY; PROLINE; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; RETROVIRUS; VIRION; VIRUS PARTICLE;

EID: 0033019820     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.3.1802-1808.1999     Document Type: Article

References (54)

1. Adachi, A., S. A. Spector, N. Kitamura, S. Nakanishi, O. Niwa, M. Matsuyama, and A. Ishimoto. 1984. Characterization of the env gene and long terminal repeat of molecularly cloned Friend mink cell focus-inducing virus DNA. J. Virol. 50:813-821.
2. Battini, J.-L., O. Danos, and J. M. Heard. 1995. Receptor-binding domain of murine leukemia virus envelope glycoproteins. J. Virol. 69:713-719.
3. Battini, J.-L., J. M. Heard, and O. Danos. 1992. Receptor choice determinants in the envelope glycoproteins of amphotropic, xenotropic, and polytropic murine leukemia viruses. J. Virol. 66:1468-1475.
4. Battini, J. L., S. C. Kayman, A. Pinter, J. M. Heard, and O. Danos. 1994. Role of N-linked glycosylation in the activity of the Friend murine leukemia virus SU protein receptor-binding domain. Virology 202:496-499.
5. Bosselman, R. A., F. V. Straaten, C. V. Beveren, I. M. Verma, and M. Vogt. 1982. Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA. J. Virol. 44:19-31.
6. Cosset, F.-L., F. J. Morling, Y. Takeuchi, R. A. Weiss, M. K. L. Collins, and S. J. Russell. 1995. Retroviral retargeting by envelopes expressing an N-terminal binding domain. J. Virol. 69:6314-6322.
7. Fass, D., R. A. Davey, C. A. Hamson, P. S. Kim, J. M. Cunningham, and J. M. Berger. 1997. Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 Angstrom resolution. Science 277:1662-1666.
8. Gray, K. D., and M. J. Roth. 1993. Mutational analysis of the envelope gene of Moloney murine leukemia virus. J. Virol. 67:3489-3496.
9. Han, X., N. Kasahara, and Y. W. Kan. 1995. Ligand-directed retroviral targeting of human breast cancer cells. Proc. Natl. Acad. Sci. USA 92:9747-9751.
10. Heard, J. M., and O. Danos. 1991. An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor. J. Virol. 65:4026-4032.
11. Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
12. Huston, J. S., D. Levinson, M. Mudgett-Hunter, M.-S. Tai, J. Novotny, M. N. Margolies, R. J. Ridge, R. E. Bruccoleri, E. Haber, R. Crea, and H. Oppermann. 1988. Protein engineering of antibody sites: recovery of specific activity in an anti-digoxin single chain Fv analogue produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 85:5879-5883.
13. Kasahara, N., A. M. Dozy, and Y. W. Kan. 1994. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science 266:1373-1376.
14. Kayman, S., R. Kopelman, D. Kinney, S. Projan, and A. Pinter. 1991. Mutational analysis of N-linked glycosylation sites of the Friend murine leukemia virus envelope proteins. J. Virol. 65:5323-5332.
15. Kayman, S. C., Z. Wu, K. Revesz, H.-C. Chen, R. Kopelman, and A. Pinter. 1994. Presentation of native epitopes in the V1/V2 and V3 domains of HIV-1 gp120 by fusion glycoproteins containing fragments of gp120. J. Virol. 68: 400-410.
16. Koch, W., W. Zimmerman, A. Oliff, and R. Friedrich. 1984. Molecular analysis of the envelope gene and long terminal repeat of Friend mink cell focus-inducing virus: implications for the functions of these sequences. J. Virol. 49:828-840.
17. Leamnson, R. N., M. H. M. Shander, and M. S. Halpern. 1977. A structural protein complex in Moloney leukemia virus. Nature 227:680-685.
18. Lenz, J., R. Crowther, A. Straceski, and W. Haseltine. 1982. Nucleotide sequence of the Akv env gene. J. Virol. 42:519-529.
19. Li, Z., A. Pinter, and S. C. Kayman. 1997. The critical N-linked glycan of murine leukemia virus envelope protein promotes both folding of the C-terminal domains of the precursor polyprotein and stability of the post-cleavage envelope complex. J. Virol. 71:7012-7019.
20. Linder, M., D. Linder, J. Hahnen, H.-H. Schott, and S. Stirm. 1992. Localization of the intrachain disulfide bonds of the envelope glycoprotein 71 from Friend murine leukemia virus. Eur. J. Biochem. 203:65-73.
21. Marin, M., D. Noel, S. Valsesia-Wittman, F. Brockly, M. Etienne-Julan, S. Russell, F.-L. Cosset, and M. Piechaczyk. 1996. Targeted infection of human cells via major histocompatibility complex class I molecules by Moloney murine leukemia virus-derived viruses displaying single-chain antibody fragment-envelope fusion proteins. J. Virol. 70:2957-2962.
22. Merregaert, J., M. Janowski, and E. P. Reddy. 1987. Nucleotide sequence of a Radiation Leukemia Virus genome. Virology 158:88-102.
23. Montelaro, R. C., S. J. Sullivan, and D. P. Bolognesi. 1978. An analysis of type-C retrovirus polypeptides and their associations in the virion. Virology 84:19-31.
24. Moore, J. P., Q. J. Sattentau, H. Yoshiyama, M. Thali, M. Charles, N. Sullivan, S.-W. Poon, M. S. Fung, F. Traincard, M. Pincus, G. Robey, J. E. Robinson, D. D. Ho, and J. Sodroski. 1993. Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains. J. Virol. 67:6136-6151.
25. Morgan, R. A., O. Nussbaum, D. D. Muenchau, L. Shu, L. Couture, and W. F. Anderson. 1993. Analysis of the functional and host range-determining regions of the murine ecotropic and amphotropic retrovirus envelope proteins. J. Virol. 67:4712-4721.
26. Oliff, A. I., G. L. Hager, E. H. Change, E. M. Scolnick, H. W. Chan, and D. R. Lowy. 1980. Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus. J. Virol. 33:475-486.
27. O'Neill, R. R., C. E. Buckler, T. S. Theodore, M. A. Martin, and R. Repaske. 1985. Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus. J. Virol. 53:100-106.
28. Opstelten, D.-J. E., M. Wallin, and H. Garoff. 1998. Moloney murine leukemia virus envelope protein subunits, gp70 and Pr15E, form a stable disulfide-linked complex. J. Virol. 72:6537-6545.
29. Ott, D., and A. Rein. 1992. Basis for receptor specificity of nonecotropic leukemia virus surface glycoprotein gp70(SU). J. Virol. 66:4632-4638.
30. Ott, D., R. Friedrich, and A. Rein. 1990. Sequence analysis of amphotropic and 10A1 murine leukemia viruses: close relationship to mink cell focus-inducing viruses. J. Virol. 64:757-766.
31. Pinter, A. 1989. Functions of murine leukemia virus envelope products in leukemogenesis, p. 20-39. In H. Hanafusa, A. Pinter, and M. Pullman (ed.), Retroviruses and disease. Academic Press, San Diego, Calif.
32. Pinter, A., and E. Fleissner. 1977. The presence of disulfide-linked gp70-p15(E) complexes in AKR MuLV. Virology 83:417-422.
33. Pinter, A., and E. Fleissner. 1979. Characterization of oligomeric complexes of murine and feline leukemia virus envelope and core components formed upon crosslinking. J. Virol. 30:157-165.
34. Pinter, A., and W. J. Honnen. 1983. Topography of murine leukemia virus envelope proteins: characterization of transmembrane components. J. Virol. 46:1056-1060.
35. Pinter, A., and W. J. Honnen. 1984. Characterization of structural and immunological properties of specific domains of Friend ecotropic and dualtropic murine leukemia virus gp70s. J. Virol. 49:452-458.
36. Pinter, A., and W. J. Honnen. 1988. O-linked glycosylation of retroviral envelope gene products. J. Virol. 62:1016-1021.
37. Pinter, A., W. J. Honnen, S. C. Kayman, O. Troshev, and Z. Wu. 1998. Potent neutralization of primary HIV-1 isolates by antibodies directed against epitopes present in the V1/V2 domain of HIV-1 gp120. Vaccine 16:1803-1811.
38. Pinter, A., W. J. Honnen, M. E. Racho, and S. A. Tilley. 1993. A potent, neutralizing human monoclonal antibody against a unique epitope overlapping the CD4-binding site of HIV-1 gp120 that is broadly conserved across North American and African virus isolates. AIDS Res. Hum. Retroviruses 9:985-996.
39. Pinter, A., R. Kopelman, Z. Li, S. C. Kayman, and D. A. Sanders. 1997. Localization of the labile disulfide bond between SU and TM of the murine leukemia virus envelope protein complex to a highly conserved CWLC motif in SU that resembles the active-site sequence of thiol-disulfide exchange enzymes. J. Virol. 71:8073-8077.
40. Poon, R. Y. C., and T. Hunt. 1994. Reversible immunoprecipitation using histidine-or glutathione S-transferase-tagged staphylococcal protein A. Anal. Biochem. 218:26-33.
41. Quint, W., W. Boelens, P. V. Wezenbeck, E. R. Maandag, and A. Berns. 1984. Generation of AKR mink cell focus-forming virus: nucleotide sequence of the 3′ end of a somatically acquired AKR-MCF. Virology 136:425-434.
42. Rassart, E., L. Nelbach, and P. Jolicoeur. 1986. Cas-Br-E murine leukemia virus: sequencing of the paralytogenic region of its genome and derivation of specific probes to study its origin and the structure of its recombinant genomes in leukemic tissues. J. Virol. 60:910-919.
43. Salmons, B., and W. H. Gunzburg. 1993. Targetting of retroviral vectors for gene therapy. Hum. Gene Ther. 4:129-141.
44. Schnierle, B. S., D. Moritz, M. Jeschke, and B. Groner. 1996. Expression of chimeric envelope proteins in helper cells and integration into Moloney murine leukemia virus particles. Gene Ther. 3:334-342.
45. Shinnick, T. M., R. A. Lerner, and J. G. Sutcliffe. 1981. Nucleotide sequence of Moloney murine leukaemia virus. Nature 293:543-548.
46. Sijts, E. J., C. J. Leupers, E. A. Mengede, W. A. Loenen, P. J. van den Elsen, and C. J. Melief. 1994. Cloning of the MCF1233 murine leukemia virus and identification of sequences involved in viral tropism, oncogenicity and T cell epitope formation. Virus Res. 34:339-349.
47. Somia, N. V., M. Zoppe, and I. M. Verma. 1995. Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery. Proc. Natl. Acad. Sci. USA 92:7570-7574.
48. Valsesia-Wittmann, S., A. Drynda, G. Deleage, M. Aumailley, J.-M. Heard, O. Danos, G. Verdier, and F.-L. Cosset. 1994. Modifications in the binding domain of avian retrovirus envelope protein to redirect the host range of retroviral vectors. J. Virol. 68:4609-4619.
49. Voytek, P., and C. A. Kozak. 1989. Nucleotide sequence and mode of transmission of the wild mouse ecotropic virus, HoMuLV. Virology 173:58-67.
50. Wang, N., T. Zhu, and D. D. Ho. 1995. Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype. J. Virol. 69:2708-2715.
51. Weiss, C. D., and J. M. White. 1993. Characterization of stable Chinese hamster ovary cells expressing wild-type, secreted, and glycosylphosphatidylinositol-anchored human immunodeficiency virus type 1 envelope glycoprotein. J. Virol. 67:7060-7066.
52. Witte, O. N., A. Tsukamoto-Adey, and I. L. Weissman. 1977. Cellular maturation of oncornavirus glycoproteins: topological arrangement of precursor and product forms in cellular membranes. Virology 76:539-553.
53. Wu, B. W., P. M. Cannon, E. M. Gordon, F. L. Hall, and W. F. Anderson. 1998. Characterization of the proline-rich region of murine leukemia virus envelope protein. J. Virol. 72:5383-5391.
54. Wu, Z., S. C. Kayman, K. Revesz, H. C. Chen, S. Warrier, S. A. Tilley, J. McKeating, C. Shotton, and A. Pinter. 1995. Characterization of neutralization epitopes in the V2 region of HIV-1 gp120: role of conserved glycosylation sites in the correct folding of the V1/V2 domain. J. Virol. 69:2271-2278.