Rational design, synthesis, and biological activity of novel conformationally restricted vitamin D analogues, (22R)- and (22S)-22-ethyl-1,25-dihydroxy-23,24-didehydro-24a,24b-dihomo-20-epivitamin D3

Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2002, Pages 1825-1834

  Masuno, Hiroyuki ^a   Yamamoto, Keiko ^a   Wang, Xinxiang ^a   Choi, Mihwa ^a   Ooizumi, Hiroshi ^b   Shinki, Toshimasa ^c   Yamada, Sachiko ^c  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

22 ETHYL 1,25 DIHYDROXY 23,24 DIDEHYDRO 24A,24B DIHOMO 20 EPIVITAMIN D3; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE;

ARTICLE; CELL DIFFERENTIATION; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ISOMERISM; LIGAND BINDING; MOLECULAR MODEL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

ANIMALS; CALCIUM; CELL DIFFERENTIATION; COS CELLS; CRYSTALLOGRAPHY, X-RAY; HL-60 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; RATS; RECEPTORS, CALCITRIOL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 0037171848     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0105631     Document Type: Article

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